The Effectiveness of Triple-Dose Albendazole in Comparison With Mebendazole for the Treatment of Trichuriasis in Children

Sungkar, Saleha; Irmawati, Fanny P.; Haswinzky, Rose A.; Dwinastiti, Yasmine A.; Wahdini, Sri; Firmansyah, Nurhadi Eko; Adawiyah, Robiatul; Buntaran, Stanley; Kekalih, Aria; Kusumowidagdo, Gladys

doi:10.22159/ijap.2019.v11s6.33559

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Therefore, the government advises the use of triple-dose albendazole for mass treatment as it tends to be safer. 5 The average Hb levels of the infected and noninfected groups in this study were within the reference range, possibly due to the mild intensity of the worm infections. However, the Hb levels and RDW were significantly different between the groups.…”

Section: Discussionmentioning

confidence: 48%

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Erythrocyte and iron profiles in soil-transmitted helminth-infected children in a rural area in Banten, Indonesia

Sungkar,

Sukartini,

Wirastuti

et al. 2024

Med J Indones

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BACKGROUND Soil-transmitted helminth (STH) infection, frequently caused by Ascaris lumbricoides, Trichuris trichiura, and hookworms (Ancylostoma duodenale and Necator americanus), often gives rise to malabsorption of nutrients that form hemoglobin (Hb) thereby causing anemia. This study aimed to know the difference in erythrocyte profile in children with and without STH infections. METHODS This cross-sectional study involved 205 children from two Panimbang Jaya elementary schools in Pandeglang, Banten, Indonesia. Blood and stool samples were collected from a previous study conducted from November 2021 to May 2022. Erythrocyte parameters were Hb concentration, erythrocyte count, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), and red cell distribution width (RDW). The iron profile included serum iron, total iron-biding capacity (TIBC), and ferritin. Worm infestation was detected by direct stool microscopical examination. Statistical analysis was performed using SPSS software version 20. RESULTS The prevalence of STH infection in Pandeglang was 44.4%, primarily characterized by mild intensity STH infection (79%). The identified STH species were A. lumbricoides, T. trichiura, and combination of both. The median differences between erythrocyte count, MCV, and MCH, and the mean differences of TIBC and serum iron were not statistically significant (p = 0.388, 0.098, and 0.057, and p = 0.304 and 0.455). However, children with STH infection had lower Hb (12.57 versus 12.95 g/dl) and ferritin (19.60 versus 30.57 µg/dl) levels but higher RDW (13.20 versus 13.10%). CONCLUSIONS A high prevalence of STH infection was identified among schoolchildren, but their erythrocyte profiles were similar regardless of STH infection status.

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Section: Discussionmentioning

confidence: 48%

“…Blood and stool examinations were conducted using previous sample collections. 5 The samples were obtained from November 2021 to May 2022.…”

Section: Methodsmentioning

confidence: 99%

Erythrocyte and iron profiles in soil-transmitted helminth-infected children in a rural area in Banten, Indonesia

Sungkar,

Sukartini,

Wirastuti

et al. 2024

Med J Indones

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Evaluation of Mucoadhesive albendazole tablets formulated using Detarium microcarpum gum

Eziuzo

Afokoghene

Benedicta

2022

RJPT

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The aim of this study was to evaluate Detarium microcarpum gum (DMG) as polymer in formulated mucoadhesive albendazole tablets. FTIR studies were conducted to evaluate compatibility of DMG with albendazole. Mucoadhesive albendazole tablets were prepared by non-aqueous wet granulation technique using DMG alone (30%, 20% or 10%), in combination with carbopol (15%/15%) or carbopol alone (30%) respectively as polymers. Granules prepared were evaluated for flow rate, angle of repose, bulk and tapped density, particle size distribution, Hausner’s ratio and compressibility index. The prepared tablets were evaluated for thickness, diameter, hardness, weight uniformity, friability, drug content, dissolution, swelling studies and mucoadhesive strength. The uniformity of weight for the formulated tablets ranged from 591.1±0.011 to 601.6±0.001 mg while the drug content ranged from 98.6% to 101.3%. Tablet hardness ranged from 5.10±000 to 10.77±0.01 Kgf and friability was between 0.25±0.00 and 0.42±0.02%. The mucoadhesive strength ranged from 1.293 x 10-4 to 6.45 x 10-4. Post compression parameters were within acceptable limits. The cumulative drug release for formulations F1-F3 produced using DMG (38.52 to 54.45%) were significant improvement on that produced using carbopol (11.62%) and marketed product (8.21%). The produced tablets were stable after accelerated stability studies at 40oC and 75% relative humidity. FTIR studies indicated that DMG did not show any incompatibility with albendazole. DMG at concentration of 30%w/w could be used to produce mucoadhesive albendazole tablets with prolonged and sustained release characteristics comparable to those produced using standard polymer, carbopol.

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The Effectiveness of Triple-Dose Albendazole in Comparison With Mebendazole for the Treatment of Trichuriasis in Children

Cited by 2 publications

References 10 publications

Erythrocyte and iron profiles in soil-transmitted helminth-infected children in a rural area in Banten, Indonesia

Erythrocyte and iron profiles in soil-transmitted helminth-infected children in a rural area in Banten, Indonesia

Evaluation of Mucoadhesive albendazole tablets formulated using Detarium microcarpum gum

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