The Effectiveness of Ultrasound Surveillance for Hepatocellular Carcinoma in a Canadian Centre and Determinants of Its Success

Khalili, Korosh; Menezes, Ravi; Kim, Tae Kyoung; Yazdi, Leyla Kochak; Jang, Hyun‐Jung; Sharma, Suraj; Feld, Jordan J.; Sherman, Morris

doi:10.1155/2015/563893

Cited by 16 publications

(20 citation statements)

References 27 publications

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“…It is becoming increasingly evident that ultrasound limitations contribute to deficiencies in HCC surveillance effectiveness in clinical practice. A prior study from Italy demonstrated ultrasound failed to detect 30% of HCC at an early stage, while another study from Canada reported ultrasound failure in approximately 25% of cases . The authors postulated this was due to a combination of aggressive tumour biology and surveillance ultrasound's imperfect sensitivity; however, they could not determine the relative contribution of each factor.…”

Section: Discussionmentioning

confidence: 96%

Predictors of adequate ultrasound quality for hepatocellular carcinoma surveillance in patients with cirrhosis

Simmons

Fetzer

Yokoo

et al. 2016

Aliment Pharmacol Ther

277

242

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Section: Discussionmentioning

confidence: 96%

Predictors of adequate ultrasound quality for hepatocellular carcinoma surveillance in patients with cirrhosis

Simmons

Fetzer

Yokoo

et al. 2016

Aliment Pharmacol Ther

277

242

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“…As the prognosis of HCC depends largely on the stage at which the tumor is detected, detection of HCC early in its development is critical to improve the survival of affected patients [218–220]. Although ultrasonography (US) is the most widely used modality for HCC screening and surveillance, the reported sensitivity of surveillance US is in the range of 40–81% with specificity of 80–100% [221–225].…”

Section: Diagnosis and Surveillancementioning

confidence: 99%

Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update

et al. 2017

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There is great geographical variation in the distribution of hepatocellular carcinoma (HCC), with the majority of all cases worldwide found in the Asia–Pacific region, where HCC is one of the leading public health problems. Since the “Toward Revision of the Asian Pacific Association for the Study of the Liver (APASL) HCC Guidelines” meeting held at the 25th annual conference of the APASL in Tokyo, the newest guidelines for the treatment of HCC published by the APASL has been discussed. This latest guidelines recommend evidence-based management of HCC and are considered suitable for universal use in the Asia–Pacific region, which has a diversity of medical environments.

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“…This suggests that, despite notable technical advancements (US machines, probes, modules, and applications), detection rate did not improve. Yet, this statement is contradicted by Khalili K et al, which, based on a more recent experience reported that detection rate did significantly increase in the latter part of the 2000s decade [59]. However, these relatively optimistic findings might be counterbalanced by a recently published Korean report, which revealed substantial discrepancies in screening quality between healthcare providers.…”

Section: Factors Affecting Us Performancementioning

confidence: 92%

Ultrasound or Sectional Imaging Techniques as Screening Tools for Hepatocellular Carcinoma: Fall Forward or Move Forward?

Spârchez

Crăciun

Caraiani

et al. 2021

JCM

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Hepatocellular carcinoma (HCC) is probably the epitome of a screening target, with a well-defined high-risk population, accessible screening methods, and multiple curative-intent treatments available for early disease. Per major societies guideline consensus, biannual ultrasound (US) surveillance of the at-risk patients is the current standard of care worldwide. Yet, despite its documented success in the past decades, this standard is far from perfect. While the whole community is working to further tighten the knots, a worrying number of cases still slip through this safety net. Consequently, these patients lose their chance to a curative solution which leads to a high disease burden with disproportionate mortality. While US will probably remain the fundamental staple in the screening strategy, key questions are seeking better answers. How can its caveats be addressed, and the technique be improved? When are further steps needed? How to increase accuracy without giving up on accessibility? This narrative review discusses the place of US surveillance in the bigger HCC picture, trying to navigate through its strengths and limits based on the most recent available evidence.

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The Effectiveness of Ultrasound Surveillance for Hepatocellular Carcinoma in a Canadian Centre and Determinants of Its Success

Abstract: A high rate of HCC surveillance success was achieved using US alone when performed regularly in a specialized hepatobiliary centre.

Cited by 16 publications

References 27 publications

Predictors of adequate ultrasound quality for hepatocellular carcinoma surveillance in patients with cirrhosis

Predictors of adequate ultrasound quality for hepatocellular carcinoma surveillance in patients with cirrhosis

Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update

Ultrasound or Sectional Imaging Techniques as Screening Tools for Hepatocellular Carcinoma: Fall Forward or Move Forward?

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