The effects and outcomes of electrolyte disturbances and asphyxia on newborns hearing

Abstract

Objective To determine the effect of electrolyte disturbances (ED) and asphyxia on infant hearing and hearing outcomes. Study Design We conducted newborn hearing screening with transient evoked otoacoustic emission (TEOAE) test on a large scale (>5,000 infants). The effects of ED and asphyxia on infant hearing and hearing outcomes were evaluated. Result The pass rate of TEOAE test was significantly reduced in preterm infants with ED (83.1%, multiple logistic regression analysis: P<0.01) but not in full-term infants with ED (93.6%, P=0.41). However, there was no significant reduction in the pass rate in infants with asphyxia (P=0.85). We further found that hypocalcaemia significantly reduced the pass rate of TEOAE test (86.8%, P<0.01). In the follow-up recheck at 3 months of age, the pass rate remained low (44.4%, P<0.01). Conclusion ED is a high-risk factor for preterm infant hearing. Hypocalcaemia can produce more significant impairment with a low recovery rate.

Hearing Status in Children with Idiopathic Nephrotic Syndrome

“…As regards hearing affection, our study showed a statistically significant lower serum Ca and corrected serum Ca in cases with hearing impairment than in cases without hearing impairment (P<0.05).There was no statistically significant difference as regards serum sodium in both groups. This is consistent with both Saha et al [6] and Liang et al [9] and El Mashad et al [10] studies. At Saha et al study, children with nephrosis and hearing impairment had low corrected serum calcium levels (P<0.04).…”

“…They found that patients with SNHL over 70 db had significantly lower serum sodium and this signifies the role of electrolyte disarray in causing SNHL. On the other hand, Liang et al [9] found no significant effect in cases with hyponatremia.…”

“…At Saha et al study, children with nephrosis and hearing impairment had low corrected serum calcium levels (P<0.04). Liang et al [9] showed that hypocalcemia significantly reduces the pass r ateof transient evoked otoacoustic emission (TEOAE) in newborns. El Mashad et al [1] concluded that children with nephrotic syndrome are at risk of sensorineural hearing impairment.…”

Pathophysiology of Perinatal Asphyxia in Humans and Animal Models

“…Ethical problems derived from the use of control groups (with no treatment) and informed consent are eliminated. However, the complexity of mechanisms and organic interactions of perinatal asphyxia, as well as the presence of multiple comorbidities, particularly those of neurological development, cause animal studies to vary in terms of species, injury methods, metabolic approach, and biospecific sample, among other factors, as can be seen in the following table of revised animal models [ 26 , 30 , 61 , 70 , 71 , 159 , 162 , 165 , 166 , 167 , 169 , 170 , 171 , 172 , 173 , 174 , 178 , 179 , 180 , 181 , 182 , 186 , 188 , 189 , 191 , 192 , 193 , 194 , 195 , 196 , 197 ].…”

Sudden sensorineural hearing loss: Is there a connection with inner ear electrolytic disorders? A literature review

“…[66][67][68] There is adequate evidence supporting the hypothesis that OAEs are very good prognostic descriptors of the status and recovery of SSNHL. [69][70][71] A 2013 Chinese study by Liang et al 72 correlated the effects of electrolyte disturbances (EDs) and asphyxia in a large newborn sample (>5000 participants), using TEOAEs. The data suggested that EDs have a very important role in the cases which fail to pass the TEOAE tests.…”