The effects of 5-HT1B characterizing agents in the mouse elevated plus-maze

5-Hydroxytryptamine2C Receptor Contribution to m-Chlorophenylpiperazine and N-Methyl-β-carboline-3-carboxamide-Induced Anxiety-Like Behavior and Limbic Brain Activation

“…(Charney et al, 1987;Lowy and Meltzer, 1988;Kahn and Wetzler, 1991;Gatch, 2003;de Mello Cruz et al, 2005). For example, m-CPP administration to mice resulted in less time spent on the open arms of an elevated plus maze (Benjamin et al, 1990), and in rats, anxiety-like behavior has been reported in the This study was supported by National Institutes of Health Grants T32 GM07628, RO1 MH34007, and R01 EB02326 and a predoctoral fellowship from the PhRMA foundation (to E.A.H. ).…”

“…Activation of 5-HT 2C receptors by 5-HT 2 receptor agonists, such as meta-chlorophenylpiperazine (m-CPP) and 6-chloro-2[1-piperazinyl] pyrazine (MK-212), elicits anxiety in humans and anxiety-like behavior in animals (Charney et al, 1987;Lowy and Meltzer, 1988;Kahn and Wetzler, 1991;Gatch, 2003;de Mello Cruz et al, 2005). For example, m-CPP administration to mice resulted in less time spent on the open arms of an elevated plus maze (Benjamin et al, 1990), and in rats, anxiety-like behavior has been reported in the light-dark box, the open-field test, and the social interaction test (Bilkei-Gorzo et al, 1998;Bagdy et al, 2001;Martin et al, 2002;Campbell and Merchant, 2003). The 5-HT 2C receptor antagonist SB 242084 blocks the anxiogenic effects of m-CPP in rats (Bagdy et al, 2001;Campbell and Merchant, 2003).…”

Phytochemicals as Antidepressants: The Involvement of Serotonin Receptor Function, Stress Resistance and Neurogenesis

“…The 5-HT 1A and 5-HT 2A receptors are the most studied receptors in relation to affective disorders. It has been shown, in both human and animal studies, that 5-HT 1A (Blier et al, 1993;Nishi et al, 2009), 5-HT 1B (Benjamin et al, 1990;Clark et al, 2002;Kaiyala et al, 2003;O'Connor et al, 1994;Saudou et al,1994;Sari, 2004), 5-HT 2A (Bhagwagar et al, 2006), and a 5-HT transporter (5-HTT) (Bhagwagar et al, 2007) play important roles in affective disorders as well as the action of antidepressants. Evidence is accumulating that dysfunction in the brain serotonergic system relates to mood and behavior disorders (Soares and Mann, 1997).…”

A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment

“…Thus, the 5-HT2CR is involved in the serotonergic regulation of generalized anxiety, depression and possibly bipolar disorders. It has been known for some time that mCPP and MK212 induce anxiogenic-like behaviours in rodents (Kennett et al 1989;Benjamin et al 1990;Shepherd et al 1994;Bilkei-Gorzo et al, 1998;Martin et al 1998;Di Giovanni et al 2001) and these compounds have been used as tools to induce anxiety and panic in humans (Lowy and Meltzer 1988;Kahn and Wetzler 1991;Sevy et al 1994;Southwick et al, 1997;Gatch 2003). The anxiogenic effects are likely due to the activation of the 5-HT2CR.…”