“…The implemented guidelines included clinical practice manuals and evidence-based treatment algorithms, which were developed with a structured methodology that included a consensus group of experts, analysis of the evidence base and clinical input. Fifteen studies 16,17,19,[21][22][23][25][26][27][28][29][30][31][32][33] assessed the impact of multifaceted implementation strategies that included two or more components. All studies implemented the guidelines at a professional level, for example by distribution of educational material, educational meetings, educational outreach visits, reminders and audit and feedback.…”