The effects of a cold-water stimulus on butorphanol effects in males and females

Zacny, James P.; Beckman, Nancy

doi:10.1016/j.pbb.2004.01.021

Cited by 27 publications

(27 citation statements)

References 31 publications

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“…However, a greater proportion of men were using opioids at program completion compared with women, but opioid use status at program completion was not modified by smoking status. Sex differences in opioid use could be due, in part, to differences in gonadal hormonal effects and pharmacodynamics [26,[34][35][36][37][38]. The differences in physical and emotional functioning that we observed between men and women are consistent with some, but not all, previously reported findings of multidisciplinary pain treatment.…”

Section: Disscusionsupporting

confidence: 87%

Sex Differences in Characteristics of Smokers with Chronic Pain Undergoing Multidisciplinary Pain Rehabilitation

et al. 2009

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Section: Disscusionsupporting

confidence: 87%

Sex Differences in Characteristics of Smokers with Chronic Pain Undergoing Multidisciplinary Pain Rehabilitation

et al. 2009

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“…The CPT has been shown to alter subjective drug effects, an effect that is observed during exposure to the painful stimulus, including ratings of ‘High’ and ‘Elated’ (Conley et al, 1997; Zacny et al, 1996a, b). In one study, pain-induced modulation of opioid subjective effects were specifically observed among women and not men (Zacny and Beckman, 2004). Although participants in the current study completed the drug effect scales after, rather than during, the CPT, it is conceivable that the repeated exposure to the painful stimulus attenuated the overall subjective effects of cannabis in a sex-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Sex-dependent effects of cannabis-induced analgesia

Cooper

Haney

2016

Drug and Alcohol Dependence

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Background Preclinical studies demonstrate that cannabinoid-mediated antinociceptive effects vary according to sex; it is unknown if these findings extend to humans. Methods This retrospective analysis compared the analgesic, subjective and physiological effects of active cannabis (3.56 - 5.60% THC) and inactive cannabis (0.00% THC) in male (N = 21) and female (N = 21) cannabis smokers under double-blind, placebo-controlled conditions. Pain response was measured using the Cold-Pressor Test (CPT). Participants immersed their hand in cold water (4°C); times to report pain (pain sensitivity) and withdraw the hand (pain tolerance) were recorded. Subjective drug ratings were also measured. Results Among men, active cannabis significantly decreased pain sensitivity relative to inactive cannabis (p < 0.01). In women, active cannabis failed to decrease pain sensitivity relative to inactive. Active cannabis increased pain tolerance in both men women immediately after smoking (p < 0.001); a trend was observed for differences between men and women (p < 0.10). Active cannabis also increased subjective ratings of cannabis associated with abuse liability (‘Take again,’ ‘Liking,’ ‘Good drug effect’), drug strength, and ‘High’ relative to inactive in both men and women (p < 0.01). Conclusions These results indicate that in cannabis smokers, men exhibit greater cannabis-induced analgesia relative to women. These sex-dependent differences are independent of cannabis-elicited subjective effects associated with abuse-liability, which were consistent between men and women. As such, sex-dependent differences in cannabis's analgesic effects are an important consideration that warrants further investigation when considering the potential therapeutic effects of cannabinoids for pain relief.

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“…In preclinical research studies using non-drug-abusing human volunteers, experimental pain induced by cold stressors modulated the subjective effects of butorphanol, i.v., in females but not males (Zacny and Beckman, 2004 antinociceptive effects in males than ovariectomized females although no difference was observed after treatment with estradiol (Negus and Mello, 1999).…”

Section: Cardiac Effectsmentioning

confidence: 99%

EVALUATION OF CARDIORESPIRATORY, BLOOD GAS, AND LACTATE VALUES DURING EXTENDED IMMOBILIZATION OF WHITE RHINOCEROS (CERATOTHERIUM SIMUM)

Buss¹,

Olea‐Popelka²,

Meyer³

et al. 2015

Journal of Zoo and Wildlife Medicine

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The effects of a cold-water stimulus on butorphanol effects in males and females

Cited by 27 publications

References 31 publications

Sex Differences in Characteristics of Smokers with Chronic Pain Undergoing Multidisciplinary Pain Rehabilitation

Sex Differences in Characteristics of Smokers with Chronic Pain Undergoing Multidisciplinary Pain Rehabilitation

Sex-dependent effects of cannabis-induced analgesia

EVALUATION OF CARDIORESPIRATORY, BLOOD GAS, AND LACTATE VALUES DURING EXTENDED IMMOBILIZATION OF WHITE RHINOCEROS (CERATOTHERIUM SIMUM)

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