The Effects of a Gluten-free Diet Versus a Hypocaloric Diet Among Patients With Fibromyalgia Experiencing Gluten Sensitivity–like Symptoms

Slim, Mahmoud; Calandre, Elena P.; García‐Leiva, Juan M.; Rico‐Villademoros, Fernando; Molina-Barea, Rocío; Rodriguez-Lopez, C.M.; Morillas-Arques, Piedad

doi:10.1097/mcg.0000000000000651

Cited by 43 publications

(64 citation statements)

References 27 publications

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“…After the removal of duplicates, a total of 7080 studies was identified in the search. Following full‐text screening, 71 studies were identified for inclusion, with 23 eligible for meta‐analysis. The abstracts for the majority of the papers were not sufficiently detailed to determine whether the full text should be retrieved.…”

Section: Resultsmentioning

confidence: 99%

“…Characteristics of the included studies are reported in Table . Approximately 30% ( n = 21) of the studies were conducted in the USA , with five undertaken in Australia , four conducted in each of Germany , Japan and Spain , and three conducted in each of Denmark , Finland , Sweden , Iran and the Netherlands . Of the included studies, 47 were randomised controlled trials (RCT) , eight were nonrandomised trials , nine were pre–post studies , six were randomised cross‐over trials and one a longitudinal study .…”

Section: Resultsmentioning

confidence: 99%

“…Assessment of study quality rated 31 studies as of positive quality , 36 as neutral and four studies were classified as being of negative study quality . Of the 33 studies classified as neutral, information regarding the randomisation process ( n = 29) or the intervention description ( n = 13) was lacking.…”

Section: Resultsmentioning

confidence: 99%

“…The most common pain‐related condition experienced by study participants was rheumatoid arthritis ( n = 19 studies) , followed by osteoarthritis ( n = 16) and fibromyalgia ( n = 13) , migraine and chronic pain ( n = 4), joint pain , back pain , diabetic neuropathy ( n = 3), chronic pancreatitis , irritable bowel syndrome (IBS) , neuropathy and headache ( n = 1). Two studies had participants with two pain‐related conditions: rheumatoid arthritis and osteoarthritis and fibromyalgia and IBS .…”

Section: Resultsmentioning

confidence: 99%

“…The VAS was followed by a pain score or pain scale ( n = 10) , The WOMAC was used in 10 studies and the SF‐36 Bodily Pain subscale was used in three studies . The remaining measurement tools were a mixture of validated questionnaires, count of painful joints, intensity of maximal pain and threshold pain values .…”

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta‐analysis of nutrition interventions for chronic noncancer pain

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Rollo

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J Human Nutrition Diet

141

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Background: This systematic review aimed to evaluate the impact of nutrition interventions on participant reported pain severity and intensity in populations with chronic pain. Methods: Eight databases were systematically searched for studies that included adult populations with a chronic pain condition, a nutrition intervention and a measure of pain. Where possible, data were pooled using meta-analysis. Seventy-one studies were included, with 23 being eligible for meta-analysis. Results: Studies were categorised into four groups: (i) altered overall diet with 12 of 16 studies finding a significant reduction in participant reported pain; (ii) altered specific nutrients with two of five studies reporting a significant reduction in participant reported pain; (iii) supplement-based interventions with 11 of 46 studies showing a significant reduction in pain; and (iv) fasting therapy with one of four studies reporting a significant reduction in pain. The meta-analysis found that, overall, nutrition interventions had a significant effect on pain reduction with studies testing an altered overall diet or just one nutrient having the greatest effect. Conclusions: This review highlights the importance and effectiveness of nutrition interventions for people who experience chronic pain.198

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review and meta‐analysis of nutrition interventions for chronic noncancer pain

Brain

Burrows

Rollo

et al. 2018

J Human Nutrition Diet

141

View full text Add to dashboard Cite

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Effects of a gluten-reduced or gluten-free diet for the primary prevention of cardiovascular disease

Schmucker

Eisele

Meerpohl

et al. 2022

Cochrane Database of Systematic Reviews

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Early Relationships of a Low‐Energy Diet With Symptoms of Fibromyalgia

Stubbs

Harte

Clauw

et al. 2022

ACR Open Rheumatology

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Objective Previous studies have demonstrated that weight loss has been shown to improve pain in weight‐bearing joints, and more recent studies suggest that weight loss may be accompanied by improvements in pain in non–weight‐bearing regions. In previous work, we demonstrated that these symptoms improve substantially in patients with obesity undergoing 12 weeks of a very low‐energy diet (VLED) restricted to 800 kcal as part of a weight‐loss program. Preclinical models also have shown analgesic effects of calorie restriction. The purpose of the current observational study was to determine the time course and trajectory of improvement in pain and other symptoms, especially during the early phase of a VLED intervention, prior to major weight loss. Methods Participants were 195 individuals with obesity who had elevated levels of pain and associated symptoms at baseline (score of ≥4 on Fibromyalgia Survey Criteria) and completed a minimum of 3 weeks of a VLED intervention. The primary outcome was improvement in Fibromyalgia Survey Criteria at week 3. In secondary analyses, we created groups of those showing little/no improvement, moderate improvement, and high improvement (little/no improvement mean, 2.21; SD, 1.02; moderate improvement mean, 2.25; SD, 0.81; high improvement mean, 2.42; SD, 0.95; F2,189 = 1.01, P = 0.37), then compared baseline characteristics. Results A large proportion of study participants (72%) experienced symptom reductions of 30% or greater by week 3, but there were no differences in the amount of weight lost at this time point. Those who showed little or no improvement (less than 30%) had a higher body mass index at baseline and were more likely to report a diagnosis of depression (both P < 0.05). Conclusion This degree of improvement after 3 weeks of a VLED is encouraging. These findings help establish the temporal pattern of symptom improvement associated with caloric restriction and suggest that the palliative effects of this diet are at least partly due to the diet itself, rather than the weight loss that ensues.

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The Effects of a Gluten-free Diet Versus a Hypocaloric Diet Among Patients With Fibromyalgia Experiencing Gluten Sensitivity–like Symptoms

Abstract: Both dietary interventions were associated with similar beneficial outcomes in reducing gluten sensitivity symptoms and other secondary outcomes. However, despite its specificity, GFD was not superior to HCD in reducing the number of gluten sensitivity symptoms or secondary outcomes.

Cited by 43 publications

References 27 publications

A systematic review and meta‐analysis of nutrition interventions for chronic noncancer pain

A systematic review and meta‐analysis of nutrition interventions for chronic noncancer pain

Effects of a gluten-reduced or gluten-free diet for the primary prevention of cardiovascular disease

Early Relationships of a Low‐Energy Diet With Symptoms of Fibromyalgia

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