The effects of a new, improved Chinese medicine, Gengnianchun formula granules, on hot flushes, depression, anxiety, and sleep in Chinese peri- and postmenopausal women: a randomized placebo-controlled trial

Zhang, Yang; Cao, Yuankui; Wang, Li

doi:10.1097/gme.0000000000001558

Cited by 9 publications

(11 citation statements)

References 26 publications

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“…Herbal formula with several herbal medicines modulates more targets compared with single compound herbal preparation. Previous studies report activities of TCM formula such as Danzhi Xiaoyao powder, Gengnianchun, and Yixin Ningshen tablet against depression (Wu et al, 2020;Zhang et al, 2020;Zhu et al, 2020). The findings of our study show that HLJDD improves depressive disorders primarily through modulation of tryptophan metabolism, dopaminergic synaptic function, and cAMP, FoxO and calcium signaling pathways.…”

Section: Discussionsupporting

confidence: 60%

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics

Xia

et al. 2021

Front. Pharmacol.

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Depressive disorder is a common mental disorder characterized by depressed mood and loss of interest or pleasure. As the Herbal medicines are mainly used as complementary and alternative therapy for depression. This study aimed at exploring antidepressant activity of Huang-lian Jie-du Decoction (HLJDD), and evaluating active components and potential depression-associated targets. HLJDD was administered on chronic unpredictable mild stress-induced (CUMS) depressive mice. Behavior evaluation was performed through force swimming test (FST), novelty-suppressed feeding test (NSF), and open field test (OFT). Active components of HLJDD, potential targets, and metabolic pathways involved in depression were explored through systemic biology-based network pharmacology assay, molecular docking and metabonomics. FST assay showed that CUMS mice administered with HLJDD had significantly shorter immobility time compared with control mice. Further, HLJDD alleviated feeding latency of CUMS mice in NSFand increased moving distance and duration in OFT. In the following network pharmacology assay, thirty-eight active compounds in HLJDD were identified based on drug-like characteristics, and pharmacokinetics and pharmacodynamics profiles. Moreover, forty-eight molecular targets and ten biochemical pathways were uncovered through molecular docking and metabonomics. GRIN2B, DRD, PRKCA, HTR, MAOA, SLC6A4, GRIN2A, and CACNA1A are implicated in inhibition of depressive symptoms through modulating tryptophan metabolism, serotonergic and dopaminergic synaptic activities, cAMP signaling pathway, and calcium signaling pathway. Further network pharmacology-based analysis showed a correlation between HLJDD and tryptophan metabolism. A total of thirty-seven active compounds, seventy-six targets, and sixteen biochemical pathways were involved in tryptophan metabolism. These findings show that HLJDD acts on potential targets such as SLC6A4, HTR, INS, MAO, CAT, and FoxO, PI3K/Akt, calcium, HIF-1, and mTOR signaling pathways, and modulates serotoninergic and dopaminergic synaptic functions. In addition, metabonomics showed that tryptophan metabolism is the primary target for HLJDD in CUMS mice. The findings of the study show that HLJDD exhibited antidepressant effects. SLC6A4 and MAOA in tryptophan metabolism were modulated by berberine, baicalein, tetrahydroberberine, candicine and may be the main antidepressant targets for HLJDD.

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Section: Discussionsupporting

confidence: 60%

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics

Xia

et al. 2021

Front. Pharmacol.

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“…GNC is a formula mainly applied clinically to alleviate perimenopausal syndrome and ovarian aging-related diseases, such as Alzheimer's disease, which was previously widely studied by our group. 12,13,29,30 Ovarian aging shares similar phenotypes with DOR, as both feature a decreased follicle pool and hypogonadal endocrine status. Thus, GNC has also been used to treat patients with DOR.…”

Section: Discussionmentioning

confidence: 99%

“…8 Traditional Chinese medicine (TCM) has promising effects on treating gynecological endocrinology dysfunctions. [9][10][11] Gengnianchun (GNC) is a previously widely reported formula in the treatment of menopausal syndrome 12 and menopause-related diseases such as Alzheimer's. 13 According to TCM theories, DOR shares a similar etiology with menopause, which is deficient in the kidney.…”

Section: Introductionmentioning

confidence: 99%

<p>Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology</p>

Gao¹,

Zhang²,

Xu³

et al. 2020

DDDT

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“…The moxibustion study reported no serious AEs and a minor AE, thirst, occurred for one participant. Among the two studies of Chinese herbal medicine, one study reported no serious AEs or AEs 22 , and one study reported one serious AE, dysplasia of squamous epithelium, which was thought not to be related to the study trial medication 18 .…”

Section: Resultsmentioning

confidence: 99%

“…The search process results of our systematic review are presented in Figure 1. This review focused on a total of 9 trials [14][15][16][17][18][19][20][21][22] of the effects of traditional East Asian medicine (TEAM) on menopausal transition symptoms (hot flashes, sleep, mood, pain, cognitive concerns), representing a total of 811 participants from 7 countries. One trial examined two interventions separately 18 .…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the effects of traditional East Asian medicine on symptom clusters during the menopausal transition

Taylor-Swanson

Sdrales

Ali

et al. 2022

Preprint

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ImportanceGiven that many midlife women use evidence-based non-pharmacologic interventions for symptom management during the menopausal transition and early postmenopause and that many women experience two or more symptoms (symptom cluster), it is important to review recent evidence on said interventions for symptom clusters. This review focuses on randomized clinical trials (RCTs) of traditional East Asian Medicine (TEAM), including acupuncture, acupressure, moxibustion, and Chinese herbal medicine, for hot flashes and one or more co-occurring symptoms experienced during peri- or post-menopause.ObjectiveThe primary objective of the study was to review RCTs (published 2011-2021) of TEAM interventions for hot flashes and at least one other co-occurring symptom, including sleep problems, cognitive function, mood, and pain.Evidence ReviewWe searched Medline, CINAHL Plus, and PsychINFO for RCTs reported in English from July 7, 2011, to December 31, 2021. We included RCTs that assessed women in the menopausal transition or early postmenopause with masking as appropriate; TEAM interventions were studied as the treatment with one or more comparison groups; hot flushes and at least one additional symptom from at least one of the symptom clusters were reported as an outcome (from sleep, mood, cognition, pain symptom groups). Bias was assessed.FindingsOf 409 abstracts identified, 9 RCTs examined the effectiveness of therapies for hot flashes and at least one additional co-occurring symptom. One study reported separately on two TEAM interventions. The maximum trial duration was 6 months (range: 5 weeks – 6 months). Statistically significant improvement was reported in 2 or more symptoms: 5 of 6 studies of acupuncture, one acupressure study, one moxibustion study, 1 of 2 studies of Chinese herbal medicine.Conclusions and RelevanceOur systematic review summarizes the recent literature on TEAM interventions for symptom clusters during the MT and EPM. A majority of studies reported symptom reduction. Overall, our findings highlight the need for further investigation with studies that include whole systems TEAM as each intervention was studied separately in the reviewed trials. Clinical practice often includes concurrent use of acupuncture, moxibustion, CHM, and advice to patients to use self-acupressure. Studying each modality separately is a scientific abstraction that does not reflect clinical practice.Key PointsQuestion/ObjectiveWhat is the effect of traditional East Asian medicine (TEAM) therapeutics, including acupuncture, acupressure, Chinese herbal medicine, or moxibustion for hot flashes and one or more co-occurring symptoms during the menopausal transition (MT)?FindingsNine RCTs (n=811) evaluating the effects of TEAM therapeutics on MT symptoms were included. Statistically significant improvement was reported in these studies: acupuncture (5 of 6), 1 acupressure study, 1 moxibustion study, and Chinese herbal medicine (1 of 2).MeaningBased on the results of this systematic review, TEAM interventions demonstrate promising improvement of hot flashes and co-occurring symptoms experienced during the MT.

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The effects of a new, improved Chinese medicine, Gengnianchun formula granules, on hot flushes, depression, anxiety, and sleep in Chinese peri- and postmenopausal women: a randomized placebo-controlled trial

Cited by 9 publications

References 26 publications

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics

Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics

<p>Therapeutic Effects of Modified Gengnianchun Formula on Stress-Induced Diminished Ovarian Reserve Based on Experimental Approaches and Network Pharmacology</p>

A systematic review of the effects of traditional East Asian medicine on symptom clusters during the menopausal transition

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