2017
DOI: 10.1186/s13063-017-1983-7
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The effects of a psychological intervention directed at optimizing immune function: study protocol for a randomized controlled trial

Abstract: BackgroundPrevious research has provided evidence for the link between psychological processes and psychophysiological health outcomes. Psychological interventions, such as face-to-face or online cognitive behavioral therapy (CBT) and serious games aimed at improving health, have shown promising results in promoting health outcomes. Few studies so far, however, have examined whether Internet-based CBT combined with serious gaming elements is effective in modulating health outcomes. Moreover, studies often did … Show more

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Cited by 6 publications
(12 citation statements)
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“…For the experimental condition, games pertaining to food and physical activity domains were used. Those games were derived from a 6-week serious game that was focused on optimizing health outcomes (Schakel et al, 2017). These games (ViaNova#) were specifically developed for this purpose through a partnership between students of Delft University of Technology which were specialized in serious games and game technology, and researchers of the Health, Medical and Neuropsychology Unit of Leiden University.…”
Section: Designmentioning
confidence: 99%
“…For the experimental condition, games pertaining to food and physical activity domains were used. Those games were derived from a 6-week serious game that was focused on optimizing health outcomes (Schakel et al, 2017). These games (ViaNova#) were specifically developed for this purpose through a partnership between students of Delft University of Technology which were specialized in serious games and game technology, and researchers of the Health, Medical and Neuropsychology Unit of Leiden University.…”
Section: Designmentioning
confidence: 99%
“…The study was conducted in accordance with the Declaration of Helsinki and the International Conference on Harmonisation Guidelines on Good Clinical Practice. Details on the study protocol and design have been published previously [ 23 ].…”
Section: Methodsmentioning
confidence: 99%
“…Briefly, healthy male participants between 18 and 35 years of age without any somatic or psychological conditions interfering with the study protocol were eligible to participate in the study. We only included male participants as the menstrual cycle is known to affect immune function [ 23 , 24 ]. Participants were recruited through digital and printed flyers at various faculties of Dutch universities from February 2016 until April 2018.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…This challenge forms a direct test of the possible clinical relevance of conditioned effects. Examples of relevant challenges of the system in which the conditioned response is to occur are a physiological histamine challenge for conditioned antiallergic responses (Meeuwis, van Middendorp, Veldhuijzen, Pacheco-Lopez, & Evers, 2017), exposure to an immunostimulating vaccination after a psychological training aimed to optimize the immune system (Schakel et al, 2017), or exposure to emotional stimuli, infant crying sounds, and pain during an MRI scan after conditioning with oxytocin (Skvortsova et al, 2016).…”
Section: Bridging the Gap Between Lab And Practice: Increasing The Exmentioning
confidence: 99%