The effects of a single high-dose injection of vitamin-D on healing of condylar fractures in osteoporotic rats

Abstract

Aim: In this study we have tried to show the effects of a single high-dose ınjection of vitamin d on healing of condylar fractures in osteoporotic rats. Materials and method: This study included sixteen female wistar rats. All rats were overiectomized. Osteoporotic rats were randomly divided into two groups of eight animals/ group. Group D animals received a single high dose of vitamin D (50.000 IU/kg) intraperitoneally and group C (control) animals received saline (0.05 mL) intraperitoneally. All injections were given immediately after condylar fracture. All rats were euthanized after 28 days, examined histopathological and immunohistochemical. Results: Histopathological and immunohistochemical evaluations were done. Histopathological scores between group D and C were found statistically significant. TGFβ1 and osteopentin levels in group D were found higher than group C. Conclusion: We have determined that a single high-dose injection of vitamin D given immediately after surgery increased TGFβ and osteopontin levels and enhanced new bone formation at condylar fractures of osteoporotic rats.