The Effects of a Variety of Hemodynamic Changes on the Rapid and Slow Components of the Circulation in the Human Forearm1

Freis, Edward D.; Schnaper, H. William

doi:10.1172/jci103674

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…In addition, there were situations where total flow could increase with either an increase or no change to nutritive flow (Hudlicka 1973). Most notable amongst these was exercise where both nutritive and non‐nutritive flow increased together (Freis & Schnapper 1958), and emotional stress where total blood flow rose without change in apparent nutritive flow (Brod et al . 1966).…”

Section: Recent Evidence For Non‐nutritive Routes In Musclementioning

confidence: 99%

Nutritive and non‐nutritive blood flow: rest and exercise

Clark

Rattigan

Clerk

et al. 2000

Acta Physiologica Scandinavica

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There is growing evidence to support the notion of two vascular routes within, or closely associated with skeletal muscle. One route is in intimate contact with muscle cells (hence is known as 'nutritive') and the other functions as a vascular shunt (and has had the interesting misnomer of 'non-nutritive'). Recent findings suggest that the 'non-nutritive' route may, in part, be those vessels in closely associated (interlacing?) connective tissue that nourishes attached fat cells, and may form the basis of 'marbling' of muscle in obesity. In addition, embolism studies using various size microspheres indicate that the 'non-nutritive' vessels are likely to be capillaries fed by terminal arterioles that branch from the same transverse arterioles as those supplying terminal arterioles of the muscle capillaries (i.e. two vascular systems operating in parallel). The proportion of flow distributed between the two routes is tightly regulated and controls muscle metabolism and contraction by regulating hormone and substrate delivery as well as product removal. Because a high proportion of nutritive flow may elevate the set point for basal metabolism, a low proportion of nutritive flow in muscle at rest confers an evolutionary advantage, particularly when food is scarce. In addition, the proportion of flow that is carried by the non-nutritive routes at rest affords a flow reserve that can be switched to the nutritive route to amplify nutrient supply during exercise. Alternatively the non-nutritive route may allow flow to escape when active muscle contraction compresses its nutritive capillaries. Thus rhythmic oscillation of blood flow between the non-nutritive and nutritive networks may aid the muscle pump.

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Section: Recent Evidence For Non‐nutritive Routes In Musclementioning

confidence: 99%

Nutritive and non‐nutritive blood flow: rest and exercise

Clark

Rattigan

Clerk

et al. 2000

Acta Physiologica Scandinavica

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The effect of increased metabolic rate and denervation on CO2 storage in muscle

Giordano

Tuteur

Longobardo

et al. 1973

Respiration Physiology

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The Characteristics of the Peripheral Transport of C14-Labeled Palmitic Acid *

Friedberg¹,

Klein²,

Trout³

et al. 1960

J. Clin. Invest.

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METHODS AND MATERIALSStudies were carried out in male hospital patients who were above age 35 and who had been fasted for 10 to 15 hours. All but one subject were free of serious disease and none was diabetic.Sixteen subjects were studied by infusing into an arm vein 0.004 to 0.010 mc of albumin-bound palmitic acid-1-C14 by means of a Bowman constant infusion pump.' Individual dosage was determined according to age. One seriously ill aphasic patient with a progressive degenerative central nervous system disorder received 0.030 mc over a period of 3 hours. The albumin-bound palmitic acid-i-C1 was prepared as previously described (3) and mixed with an appropriate amount of physiological saline solution so that the desired amount of label could be administered at the rate of 2.1 ml of solution per *

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The Effects of a Variety of Hemodynamic Changes on the Rapid and Slow Components of the Circulation in the Human Forearm1

Cited by 3 publications

References 6 publications

Nutritive and non‐nutritive blood flow: rest and exercise

Nutritive and non‐nutritive blood flow: rest and exercise

The effect of increased metabolic rate and denervation on CO2 storage in muscle

The Characteristics of the Peripheral Transport of C14-Labeled Palmitic Acid *

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