The effects of acetyl-11-keto-β-boswellic acid on brain cytokines and memory impairment induced by lipopolysaccharide in rats

Marefati, Narges; Beheshti, Farimah; Memarpour, Sara; Bayat, Reza; Shafei, Mohammad Naser; Sadeghnia, Hamid Reza; Ghazavi, Hamed; Hosseini, Mahmoud

doi:10.1016/j.cyto.2020.155107

Cited by 45 publications

(34 citation statements)

References 42 publications

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“…Central or peripheral administration of an endotoxin, lipopolysaccharide (LPS), results in neuroinflammation by inducing the releases of cytokines including TNF-α, IL-1β, and IL-6 through activation of microglia [ 7 ]. Furthermore, the elevation of these cytokines induces the proliferation of APP expression and amyloidogenesis in AD [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice

et al. 2021

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Clobenpropit (CLO), an antagonist on histamine H3 receptors (HH3R), has been shown to protect NMDA-induced neuronal necrosis in cortical neuronal cell culture from rats. In this work, we explored its potential on lipopolysaccharide (LPS)-induced memory deficits, neuroinflammation, and mitochondrial dysfunction in mice. CLO (1 and 3 mg/kg, p.o.) was treated continually for 30 days, and neurotoxicity was induced by four doses of LPS (250 µg/kg, i.p.). The radial arm maze (RAM) was used to access memory behaviors. After the REM test, brain tissue was collected from each mouse to estimate pro-inflammatory cytokines (TNFα and IL6), anti-inflammatory cytokines (TGF-β1 and IL-10), cyclooxygenase-2 (COX 2), and mitochondrial respiratory chain complex (MRCC- I, II and IV) enzymes. CLO treatment reversed the LPS-induced behavioral deficits by a significant reduction in time taken to consume all five bites (TTB), working memory error (WME), and reference memory error (REM) in the REM test. Regarding neuroinflammation, it attenuated the release of COX, TNF-α, and IL-6, and augmented TGF-β1 and IL-10 levels in the brain. Reversal of LPS-induced brain MRCC (I, II, and IV) levels also resulted with CLO treatment. From these findings, CLO promises neuroprotection against LPS-induced cognitive deficits by ameliorating neuroinflammation and restoring the MRCC enzymes in mice.

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Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice

et al. 2021

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“…Desmethoxyyangonin, dihydromethysticin, flavokawain A, and flavokawain C, as the major chemical constituents of Piper methysticum Forst., have exhibited significant anti-inflammatory, anti-cancer, and neuro-protective effects [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. 11-keto-β-boswellic acid is a triterpenoid found in Boswellia serrata and has potential therapeutic efficacy against several chronic inflammatory diseases and neurodegenerative diseases [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. Asperuloside, which is classified under the category of iridoid glycosides, has potential for the treatment of obesity, inflammatory diseases, cancer, bacterial infection, and renal fibrosis [ 61 , 62 , 63 , 64 , 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

Cheng

Zhou

et al. 2022

Molecules

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As cannabinoid CB2 receptors (CB2R) possess various pharmacological effects—including anti-epilepsy, analgesia, anti-inflammation, anti-fibrosis, and regulation of bone metabolism—without the psychoactive side effects induced by cannabinoid CB1R activation, they have become the focus of research and development of new target drugs in recent years. The present study was intended to (1) establish a double luciferase screening system for a CB2R modulator; (2) validate the agonistic activities of the screened compounds on CB2R by determining cAMP accumulation using HEK293 cells that are stably expressing CB2R; (3) predict the binding affinity between ligands and CB2 receptors and characterize the binding modes using molecular docking; (4) analyze the CB2 receptors–ligand complex stability, conformational behavior, and interaction using molecular dynamics; and (5) evaluate the regulatory effects of the screened compounds on bone metabolism in osteoblasts and osteoclasts. The results demonstrated that the screening system had good stability and was able to screen cannabinoid CB2R modulators from botanical compounds. Altogether, nine CB2R agonists were identified by screening from 69 botanical compounds, and these CB2R agonists exhibited remarkable inhibitory effects on cAMP accumulation and good affinity to CB2R, as evidenced by the molecular docking and molecular dynamics. Five of the nine CB2R agonists could stimulate osteoblastic bone formation and inhibit osteoclastic bone resorption. All these findings may provide useful clues for the development of novel anti-osteoporotic drugs and help elucidate the mechanism underlying the biological activities of CB2R agonists identified from the botanical materials.

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“…T A B L E 1 Anti-inflammatory, anticancer, and memory-boosting effects of frankincense or its ingredients examined by some in vitro, in vivo and clinical trials The putative anti-inflammatory, anti-allergic, anti-oxidant, antitumor and analgesic nature of Frankincense has traditionally been exploited to treat inflammatory-related disease without noticeable toxicity (Beheshti & Karimi, 2016;Marefati et al, 2020). Its therapeutic effect on chronic inflammatory diseases like chronic colitis, ulcerative colitis, Crohn's disease, inflammatory bowel disease, polyuria, diabetes, asthma, arthritis, bronchitis, scrofula, syphilis, and others such as amnesia, memory impairment, stress, and cancer has documented in several studies (Ebrahimpour et al, 2017;Estelami et al, 2016;Holleran et al, 2020;Jebelli et al, 2019a;Marefati et al, 2020;Sedighi et al, 2014;Wei et al, 2020). It is also beneficial in wound healing and improved operation of the female endocrine system (Marefati et al, 2020).…”

Section: Anti-inflammatory Effects Of Frankincensementioning

confidence: 99%

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

Khajehdehi

Khalaj‐Kondori

Baradaran

2022

Phytotherapy Research

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Chemical diversity of natural products with drug-like features has attracted much attention from medicine to develop more safe and effective drugs. Their anti-inflammatory, antitumor, analgesic, and other therapeutic properties are sometimes more successful than chemical drugs in controlling disease due to fewer drug resistance and side effects and being more tolerable in a long time. Frankincense, the oleo gum resin extracted from the Boswellia species, contains some of these chemicals. The anti-inflammatory effect of its main ingredient, boswellic acid, has been traditionally used to treat many diseases, mainly those target memory functions. In this review, we have accumulated research evidence from the beneficial effect of Frankincense consumption in memory improvement and the prevention of inflammation and cancer. Besides, we have discussed the molecular pathways mediating the therapeutic effects of this natural supplement.

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The effects of acetyl-11-keto-β-boswellic acid on brain cytokines and memory impairment induced by lipopolysaccharide in rats

Cited by 45 publications

References 42 publications

Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice

Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice

Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects

Molecular evidences on anti‐inflammatory, anticancer, and memory‐boosting effects of frankincense

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