The effects of acute and chronic administration of corticosterone on rat behavior in two models of fear responses, plasma corticosterone concentration, and c-Fos expression in the brain structures

Skórzewska, Anna; Bidziński, Andrzej; Lehner, Małgorzata; Turzyńska, Danuta; Wisłowska-Stanek, Aleksandra; Sobolewska, Alicja; Szyndler, Janusz; Maciejak, Piotr; Taracha, Ewa; Płaźnik, Adam

doi:10.1016/j.pbb.2006.10.001

Cited by 64 publications

(31 citation statements)

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“…Here I have reported no effect on fear conditioning to tone and context following chronic stress. This supports the previous findings of Miracle et al (2006), but Skorzewska et al (2006) reported an enhancement following chronic CORT treatment.…”

Section: Discussionsupporting

confidence: 92%

“…There was a slight increase in the amount of freezing observed in the groups that had been phase shifted dining contextual fear conditioning. This was likely due to the stress of the phase shift (Sakellaris et al, 1975) as increased freezing during this task has been reported previously in rats treated chronically with corticosterone (CORT; Skorzewska et al, 2006). There were no differences between the two phase shifted groups, suggesting that the cholinergic depletion did not modify this behaviour.…”

Section: Discussionsupporting

confidence: 63%

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Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

Craig

Hong

McDonald

2011

Neuroscience & Biobehavioral Reviews

410

263

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Alzheimer's disease (AD) is the most common form of dementia affecting the elderly population today; however, there is currently no accurate description of the etiology of this devastating disorder. No single factor theory has been demonstrated as being causative; however, an alternative theory suggests that the interaction of multiple risk factors is responsible for AD. In this thesis I present data suggesting a neuroprotective role for acetylcholine during aging. Using a rat model of cholinergic depletion of the medial septum, I explored the effects of four common risk factors for AD (stress, seizures, stroke and circadian dysfunction) targeted at the hippocampus and examined the effects on measures of hippocampal dependent (water maze) and hippocampal independent (fear conditioning) memory. Here, I propose a role for acetylcholinemediated compensatory mechanisms in the functional recovery observed following sub threshold insults similar to those commonly observed in the elderly. m First and foremost I would like to thank my supervisor, Dr. Robert McDonald. Thank you for your support and encouragement, and for allowing me the independence to pursue my own projects and to learn from my experiences. I would also like to thank Nhung Hong for doing the majority of the cholinergic depletion and stroke surgeries used in this thesis and for teaching me the techniques. I would like to give a huge thank you to Joelle Kopp who was an invaluable asset who assisted in histology and spent many hours on the microscope counting cholinergic neurons. I would also like to thank Dr. Christine Werk for patiently reading and re-reading early drafts of my papers and this thesis and Dr.Hugo Lehmann for all his help in running statistics and interpreting my data. In addition, many thanks go out to Courtney Lamb, Robert Court and Arthur Verhoef for helping me with histology and behavioural testing, to Keri Colwell for running the corticosterone assays, the Metz lab for kindly allowing me the use of their microscope and to Karen Dow-Cazel and the rest of the animal care staff for taking care of my rats and helping me set up the circadian experiements. The cholinergic hypothesis of Alzheimer's disease 6 Acknowledgements IVThe basal forebrain cholinergic system 8The role of the basal forebrain cholinergic system in learning and memory 10The current state of the cholinergic hypothesis of Alzhimer's disease 15Risk factors for Alzheimer's disease 16Multiple combinations of co-factors theory of Alzheimer's disease 22The role of the hippocampus in learning and memory 24Objective of the present thesis 25Chapter 2: A series of pilot studies to determine the threshold for behaviourally sub threshold stroke, seizures and stress 28Abstract 29Experiment la: The effect of a chronic variable stress schedule on performance of the water maze task 32 Materials and Methods 33Results 36Experiment lb: The effects of a variable restraint stress procedure on levels of blood borne CORT 39 Materials and Methods 39Results 40Discussion 41Experiment 2: T...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 63%

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

Craig

Hong

McDonald

2011

Neuroscience & Biobehavioral Reviews

410

263

View full text Add to dashboard Cite

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“…In addition to the BST-containing cluster, which is discussed in detail below, there were also hypermetabolic clusters covering the cingulate area and parts of the right entorhinal cortex, which is consistent with previous studies that implicate the cingulate cortex in contextual conditioning (Beck and Fibiger, 1995;Pietersen et al, 2006;Skó rzewska et al, 2006). In addition, the anterior cingulate cortex has been implicated in anticipatory anxiety, which may be relevant when expecting an aversive stimulus (Nitschke et al, 2006).…”

Section: Discussionsupporting

confidence: 87%

Micro-Positron Emission Tomography Imaging of Rat Brain Metabolism during Expression of Contextual Conditioning

Luyten¹,

Casteels²,

Vansteenwegen³

et al. 2012

J. Neurosci.

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Using 18F-fluorodeoxygluose microPET imaging, we investigated the neurocircuitry of contextual anxiety versus control in awake, conditioned rats (n ϭ 7-10 per group). In addition, we imaged a group expressing cued fear. Simultaneous measurements of startle amplitude and freezing time were used to assess conditioning. To the best of our knowledge, no neuroimaging studies in conditioned rats have been conducted thus far, although visualizing and quantifying the metabolism of the intact brain in behaving animals is clearly of interest. In addition, more insight into the neurocircuitry involved in contextual anxiety may stimulate the development of new treatments for anxiety disorders. Our main finding was hypermetabolism in a cluster comprising the bed nucleus of the stria terminalis (BST) in rats expressing contextual anxiety compared with controls. Analysis of a subset of rats showing the best behavioral results (n ϭ 5 per subgroup) confirmed this finding. We also observed hypermetabolism in the same cluster in rats expressing contextual anxiety compared with rats expressing cued fear. Our results provide novel evidence for a role of the BST in the expression of contextual anxiety.

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“…Immediately after acute exposure to GC, hippocampal-dependent information processing is impaired, but an hour to days later hippocampal long-term potentiation is enhanced [121]. GC injections 90 min before behavioural testing caused enhanced exploratory behaviour and decreased fear behaviour in rats, but when exposed to repeated GC administration for 25 days, rats were less exploratory and displayed enhanced fear behaviour [116]. Acute actions of GCs may enhance processing of stress-related information, which helps the individual to cope with similar future challenges, but effects of sustained GC elevations may overpower adaptive responses to acute stress.…”

Section: (B) Cues That Alter Glucocorticoid Productionmentioning

confidence: 99%

Sex, social status and physiological stress in primates: the importance of social and glucocorticoid dynamics

Cavigelli

Caruso

2015

Phil. Trans. R. Soc. B

102

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Social status has been associated with health consequences, although the mechanisms by which status affects health are relatively unknown. At the physiological level, many studies have investigated the potential relationship between social behaviour/rank and physiological stress, with a particular focus on glucocorticoid (GC) production. GCs are of interest because of their experimentally established influence on health-related processes such as metabolism and immune function. Studies in a variety of species, in both naturalistic and laboratory settings, have led to complex outcomes. This paper reviews findings from primates and rodents and proposes a psychologically and physiologically relevant framework in which to study the relationship between social status and GC function. We (i) compare status-specific GC production between male and female primates, (ii) review the functional significance of different temporal patterns of GC production, (iii) propose ways to assess these temporal dynamics, and (iv) present novel hypotheses about the relationship between social status and GC temporal dynamics, and potential fitness and health implications. To understand whether GC production mediates social status-related fitness disparities, we must consider social contest conditions and the temporal dynamics of GC production. This framework will provide greater insights into the relationship between social status, physiological stress and health.

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The effects of acute and chronic administration of corticosterone on rat behavior in two models of fear responses, plasma corticosterone concentration, and c-Fos expression in the brain structures

Cited by 64 publications

References 65 publications

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

Micro-Positron Emission Tomography Imaging of Rat Brain Metabolism during Expression of Contextual Conditioning

Sex, social status and physiological stress in primates: the importance of social and glucocorticoid dynamics

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