The Effects of Adherence to Non-Steroidal Anti-Inflammatory Drugs and Factors Influencing Drug Adherence in Patients with Knee Osteoarthritis

Park, Kwan Kyu; Choi, Choong-Hyeok; Ha, Chul‐Won; Lee, Myung Chul

doi:10.3346/jkms.2016.31.5.795

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…Treatments are limited with no therapies that directly target the disease; instead, the focus is on relieving symptoms and improving function. This is achieved through the use of painkilling medications in combination with physiotherapy, as well as educating patients to manage their weight, with the last resort being total joint replacement [2]. Understanding where and when to target OA progression is complex due to the multifactorial nature of OA development.…”

Section: Introductionmentioning

confidence: 99%

Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli

et al. 2019

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Osteoarthritis (OA) is a degenerative condition caused by dysregulation of multiple molecular signalling pathways. Such dysregulation results in damage to cartilage, a smooth and protective tissue that enables low friction articulation of synovial joints. Matrix metalloproteinases (MMPs), especially MMP-13, are key enzymes in the cleavage of type II collagen which is a vital component for cartilage integrity. Transforming growth factor beta (TGFβ) can protect against pro-inflammatory cytokine-mediated MMP expression. With age there is a change in the ratio of two TGFβ type I receptors (Alk1/Alk5), a shift that results in TGFβ losing its protective role in cartilage homeostasis. Instead, TGFβ promotes cartilage degradation which correlates with the spontaneous development of OA in murine models. However, the mechanism by which TGFβ protects against pro-inflammatory responses and how this changes with age has not been extensively studied. As TGFβ signalling is complex, we used systems biology to combine experimental and computational outputs to examine how the system changes with age. Experiments showed that the repressive effect of TGFβ on chondrocytes treated with a pro-inflammatory stimulus required Alk5. Computational modelling revealed two independent mechanisms were needed to explain the crosstalk between TGFβ and pro-inflammatory signalling pathways. A novel meta-analysis of microarray data from OA patient tissue was used to create a Cytoscape network representative of human OA and revealed the importance of inflammation. Combining the modelled genes with the microarray network provided a global overview into the crosstalk between the different signalling pathways involved in OA development. Our results provide further insights into the mechanisms that cause TGFβ signalling to change from a protective to a detrimental pathway in cartilage with ageing. Moreover, such a systems biology approach may enable restoration of the protective role of TGFβ as a potential therapy to prevent age-related loss of cartilage and the development of OA.

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Section: Introductionmentioning

confidence: 99%

Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli

et al. 2019

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“…NSAIDs are the drugs most frequently used for the treatment of pain from osteoarthritis, and are 30% more effective in eliminating pain than high dose acetaminophen [ 21 , 22 ]. However, it does not have any effect on some patients, and has several side effects on the upper gastrointestinal tract including indigestion, vomiting and ulcer edema [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, since the action that particularly suppresses cyclooxygenase-2, also has a side effect on the cardiovascular system, its use is limited [ 24 ]. Thus, a safer and more effective medicine is required [ 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-osteoarthritic effects of ChondroT in a rat model of collagenase-induced osteoarthritis

Jeong

Bae

Kim

et al. 2018

BMC Complement Altern Med

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BackgroundPreviously, we reported that ChondorT showed significant anti-arthritis and anti-inflammatory effects. ChondroT, a new herbal medication, consists of the water extracts of Osterici Radix, Lonicerae Folium, Angelicae Gigantis Radix, Clematidis Radix, and Phellodendri Cortex (6:4:4:4:3). The objective of this study was to investigate the effects of ChondroT in collagenase-induced osteoarthritis rat model.MethodsOsteoarthritis was induced by the injection of collagenase into the right knee joint cavity of rats. The samples were divided into seven groups [intact (n = 6), control (n = 6), indomethacin (n = 6), Joins tab (n = 6), ChondroT50 (n = 6), ChondroT100 (n = 6), and ChondroT200 (n = 6)]. The control group was administered normal saline, indomethacin group was administered indomethacin (2 mg/kg), and Joins tab group was administered Joins Tab (20 mg/kg). The ChondroT50, ChondroT100, and ChondroT200 groups were administered 50, 100, and 200 mg/kg of ChondroT, respectively. All oral administrations were initiated 7 days after the induction of arthritis and were continued for a total of 12 days. At the end of the experiment, serum aminotransferase, albumin, blood urea nitrogen, creatinine, leukocyte, and inflammatory cytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6] were analyzed. Hematoxylin and eosin (H&E) and safranin O-fast green staining of the articular structures of the knee joint were performed.ResultsTNF-α and IL-1β decreased in the ChondroT100 and ChondroT200 groups compared with those in the control group. IL-6 and aspartate aminotransferase decreased in the ChondroT50, ChondroT100, and ChondroT200 groups compared with that in the control group. Albumin, WBC and lymphocytes decreased in the ChondroT100 and ChondroT200 groups compared with those in the control group. In H&E stain, synoviocytes, cartilage lacunae, and chondrocytes were well preserved in the ChondroT100 and ChondroT200 groups, and safranin O-fast staining showed a clear reaction of proteoglycans in the ChondroT100 and ChondroT200 groups.ConclusionsBased on these results, it can be proposed that ChondroT has anti-osteoarthritic effects on collagenase-induced rat model.

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“…Duration of pain relief is an important consideration for analgesic medications, because higher dosing frequency is associated with nonadherence among chronic pain patients [57]. Better adherence to analgesic regimens may reduce suffering and improve physical functioning [58], and the link between treatment adherence/persistence and patient satisfaction has been well established across a spectrum of diseases including chronic pain states [59].…”

Section: Duration Of Effectmentioning

confidence: 99%

Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review

Revel¹,

Fayet²,

Hagen³

2020

Rheumatol Ther

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Multiple head-to-head trials have demonstrated that topical nonsteroidal anti-inflammatory drugs (NSAIDs), including topical diclofenac, provide at least equivalent analgesia, improvement in physical function, and reduction of stiffness compared with oral NSAIDs in osteoarthritis and have fewer systemic adverse events. While efficacy of topical diclofenac in osteoarthritis is well established, understanding of the time to onset of action, duration of effect, and the minimum effective concentration is limited. Factors likely to influence these parameters include drug penetration and localization. Diclofenac concentrations in the joint tissues are likely to be more relevant than plasma concentrations. However, although

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The Effects of Adherence to Non-Steroidal Anti-Inflammatory Drugs and Factors Influencing Drug Adherence in Patients with Knee Osteoarthritis

Cited by 9 publications

References 20 publications

Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli

Systems biology reveals how altered TGFβ signalling with age reduces protection against pro-inflammatory stimuli

Anti-osteoarthritic effects of ChondroT in a rat model of collagenase-induced osteoarthritis

Topical Diclofenac, an Efficacious Treatment for Osteoarthritis: A Narrative Review

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