The effects of administration of mCPP on psychological, cognitive, cardiovascular, hormonal and MHPG measurements in human volunteers

Dissociable Hormonal, Cognitive and Mood Responses to Neuroendocrine Challenge Evidence for Receptor-Specific Serotonergic Dysregulation in Depressed Mood

“…In contrast to a previous study in which no cognitive effects of m-CPP were reported (Silverstone et al 1994), we found impaired performance after m-CPP on all Re- action Time tasks. However, we assessed performance 3.5 h after administration whereas the previously mentioned study, performance was assessed 1-2 h after administration.…”

Serotonin Activates the Hypothalamic-Pituitary-Adrenal Axis via Serotonin 2C Receptor Stimulation

“…Consistent with their effects on CRH release, mCPP and D-fen significantly increase levels of plasma CORT (Sevy et al, 1994;Silverstone et al, 1994;Broocks et al, 2000). To determine whether 5-HT 2C Rs contribute to these actions, we compared 5-HT agonist-induced CORT release in 5-HT 2C R knock-out and wild-type mice.…”

“…The most commonly used 5-HT compounds enhancing CORT release are mCPP and fenfluramine Snoddy, 1980, 1990;Sevy et al, 1994;Silverstone et al, 1994;Broocks et al, 2000;Vielhaber et al, 2005). In addition to 5-HT 2C Rs, mCPP also has high binding affinity for the 5-HT 2A R, 5-HT 1A R, 5-HT 1B R, and 5-HT 3 R subtypes (Koe et al, 1992).…”

“…This stimulates the release of adrenocorticotropin (ACTH) from the anterior lobe of the pituitary, which in turn acts on the adrenal cortex to trigger the release of glucocorticoids, such as corticosterone/cortisol (CORT), into the bloodstream. Enhanced 5-HT neurotransmission produces potent and consistent increases in plasma concentrations of CORT, whereas depletion of the 5-HT precursor or 5-HT transporter reduces CORT Snoddy, 1980, 1990;Silverstone et al, 1994;Vielhaber et al, 2005). The prevalent use of compounds augmenting the synaptic availability of 5-HT and the alterations in adiposity and mood induced by CORT excess or deficiency highlight the importance of understanding this cross talk (Kelly et al, 1980;Gold and Chrousos, 1985;Bagdy et al, 1989;Laferrere et al, 1994;Vielhaber et al, 2005).…”

Central Serotonergic Effects of m-Chlorophenylpiperazine (mCPP) among Normal Control Adolescents

“…A study involving experimental rats failed to find a significant effect of mCPP infusion on mean arterial pressure or heart rate (Cohen et al, 1987). Similarly, most studies involving adult humans have found either no effect on heart rate (Kahn et al, 1990b) or no significant changes in both BP and heart rate (Silverstone et al, 1994;Seibyl et al, 1991). The most likely explanations for raised BP and heart rate among adolescents are either that these observations are stress-related responses or that they represent atypical development-related response to mCPP.…”