The effects of administration of ligands for Toll-like receptor 4 and 21 against Marek's disease in chickens

Parvizi, Payvand; Abdul-Careem, Mohamed Faizal; Mallick, Amirul Islam; Haq, Kamran; Haghighi, Hamid R.; Orouji, Shahriar; Heidari, Mohammad; Behboudi, Shahriar; Sharif, Shayan

doi:10.1016/j.vaccine.2014.01.082

Cited by 22 publications

(7 citation statements)

References 46 publications

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“…Notably, injection of Advax adjuvant alone without antigen did not provide any non-specific protection against influenza [22] , [24] . This contrasts with the non-specific virus protection due to nonspecific innate immune activation seen with CpG oligonucleotides and other TLR agonists [42] , [43] . This together with the fact that it doesn’t induce pyrexia even when administered at high doses suggests that Advax is not working through traditional TLR-mediated signaling pathways.…”

Section: Discussionmentioning

confidence: 93%

Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection

Honda‐Okubo

Ong

Petrovsky

2015

Vaccine

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Neonates are at high risk for influenza morbidity and mortality due to immune immaturity and lack of priming by prior exposure. Inactivated influenza vaccines are ineffective in infants under six months and to provide protection in older children generally require two doses given a month apart. This leaves few options for rapid protection of infants, e.g. during an influenza pandemic. We investigated whether Advax™, a novel polysaccharide adjuvant based on delta inulin microparticles could help overcome neonatal immune hypo-responsiveness and also whether it was possible to obtain single-dose influenza vaccine protection of babies against lethal infection. Inactivated influenza A/H1N1 vaccine (iH1N1) combined with Advax™ adjuvant administered as a single immunization to 7-day-old mouse pups significantly enhanced serum influenza-specific IgM, IgG1, IgG2a and IgG2b levels in association with a 3–4 fold increase in the frequency of splenic influenza-specific IgM and IgG antibody secreting cells versus pups immunized with iH1N1 alone. Pups immunized with Advax-adjuvanted iH1N1 had significantly higher influenza-stimulated splenocyte production of IFN-γ, IL-2, IL-4, and IL-10 and a 3–10 fold higher frequency of T cells IFN-γ secreting IL-2, IL-4 or IL-17 by ELISPOT. Immunisation with iH1N1+Advax adjuvant induced robust protection against influenza virus challenge 3 weeks post-immunization, whereas pups immunized with iH1N1 alone had no protection. Protection by Advax-adjuvanted iH1N1 was mediated by serum antibody and memory B cells rather than memory T cells as protection was lost in neonatal µMT mice that are B-cell deficient. Hence, Advax adjuvant overcame neonatal immune hypo-responsiveness and enabled single-dose protection of pups against otherwise lethal influenza infection, thereby supporting development of Advax™ as a neonatal vaccine adjuvant.

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Section: Discussionmentioning

confidence: 93%

Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection

Honda‐Okubo

Ong

Petrovsky

2015

Vaccine

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“…Ligands for TLRs are used as adjuvants that stimulate immune responses, leading to protection against infectious diseases. We have demonstrated that the administration of TLR3 [133], TLR4 and TLR21 ligands [134] reduces the incidence of tumours and MDV genome copy numbers in the infected birds. The importance of TLR in providing protection against tumour development could be extrapolated from the results demonstrating significantly higher basal expression levels of TLR3 and TLR7 in uninfected chicken cells isolated from resistant chicken lines compared to the susceptible lines [135].…”

Section: Persistence In the Face Of Vaccinationmentioning

confidence: 99%

Marek’s disease in chickens: a review with focus on immunology

Boodhoo

Gurung

Sharif

et al. 2016

Vet Res

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142

130

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Marek’s disease (MD), caused by Marek’s disease virus (MDV), is a commercially important neoplastic disease of poultry which is only controlled by mass vaccination. Importantly, vaccines that can provide sterile immunity and inhibit virus transmission are lacking; such that vaccines are only capable of preventing neuropathy, oncogenic disease and immunosuppression, but are unable to prevent MDV transmission or infection, leading to emergence of increasingly virulent pathotypes. Hence, to address these issues, developing more efficacious vaccines that induce sterile immunity have become one of the important research goals for avian immunologists today. MDV shares very close genomic functional and structural characteristics to most mammalian herpes viruses such as herpes simplex virus (HSV). MD also provides an excellent T cell lymphoma model for gaining insights into other herpesvirus-induced oncogenesis in mammals and birds. For these reasons, we need to develop an in-depth knowledge and understanding of the host-viral interaction and host immunity against MD. Similarly, the underlying genetic variation within different chicken lines has a major impact on the outcome of infection. In this review article, we aim to investigate the pathogenesis of MDV infection, host immunity to MD and discuss areas of research that need to be further explored.

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“…In addition, CpG-ODN was proven to enhance the protection mediated by LaSota NDV vaccine and LPAI H4N6 virosomes by enhancing both Ab-and cell-mediated immunity [196]. Finally, other studies demonstrated the ability of CpG-ODN-mediated adjuvant effects during IBV and ALV-J vaccination [201][202][203].…”

Section: Discussionmentioning

confidence: 99%

Avian Pattern Recognition Receptor Sensing and Signaling

Neerukonda

Katneni

2020

Veterinary Sciences

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Pattern recognition receptors (PRRs) are a class of immune sensors that play a critical role in detecting and responding to several conserved patterns of microorganisms. As such, they play a major role in the maintenance of immune homeostasis and anti-microbial defense. Fundamental knowledge pertaining to the discovery of PRR functions and their ligands continue to advance the understanding of immune system and disease resistance, which led to the rational design and/or application of various PRR ligands as vaccine adjuvants. In addition, the conserved nature of many PRRs throughout the animal kingdom has enabled the utilization of the comparative genomics approach in PRR identification and the study of evolution, structural features, and functions in many animal species including avian. In the present review, we focused on PRR sensing and signaling functions in the avian species, domestic chicken, mallard, and domestic goose. In addition to summarizing recent advances in the understanding of avian PRR functions, the present review utilized a comparative biology approach to identify additional PRRs, whose functions have been well studied in mammalians but await functional characterization in avian.

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The effects of administration of ligands for Toll-like receptor 4 and 21 against Marek's disease in chickens

Cited by 22 publications

References 46 publications

Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection

Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection

Marek’s disease in chickens: a review with focus on immunology

Avian Pattern Recognition Receptor Sensing and Signaling

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