The effects of advancing age on the connective tissue of the uterus, cervix and vagina of the rat

Wolfe, J. M.; Burack, Ethel; Lansing, Winifred; Wright, Arthur F.

doi:10.1002/aja.1000700107

Cited by 30 publications

(8 citation statements)

References 3 publications

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“…The inner longitudinal smooth muscle of the rat cervix according to Wolfe, et al (1942) which appeared at 30 days of age was relatively thin in all age groups, in comparison with the circular muscleo In young rats the smooth muscle of the cervical lips was penetrated by narrow collagen fibers and as the animals aged there wao an increase in the dilution of muscle by collagen fibers, which was always most advanced in the cervical labia. These investigators found that in markedly hypertrophied cervices of older rats the smooth muscles of this region were broken up into small aggregates of as few as 2 or 5 muscle cells, by collagen fibers up to 5 microns thick and that in part the reticulum about the muscle cells was apparently transformed into collagen to bring this about.…”

Section: Muscularissupporting

confidence: 39%

“…In the young the cells were abundant and large with typical vesicular nuclei while in the old they were relatively few in proportion to the amount of collagenous tissue and appeared predominently flattened and shrunlcen® In older rats Wolfe, et al-(1942) found that there was a marked tendency for dense collagen fibers to penetrate the longitudinal smooth muscle and divide it into widely isolated units. They indicated that in some instances this resulted in a pronounced thickening of the vaginal wall.…”

Section: Lamina Propriasupporting

confidence: 37%

“…These investigators found that in markedly hypertrophied cervices of older rats the smooth muscles of this region were broken up into small aggregates of as few as 2 or 5 muscle cells, by collagen fibers up to 5 microns thick and that in part the reticulum about the muscle cells was apparently transformed into collagen to bring this about. In the very old rats there was often a complete disappearance of reticulum with atrophy of smooth muscle cells according to Wolfe, et al (1942) They further stated that in some cases only a portion of the intima was thickened, whereas in others it was uniformly thickened all the way around. Often the distinction between the intima and media was lost thougli, due to disintegration of the internal elastic membrane.…”

Section: Muscularismentioning

confidence: 38%

“…Leathern (l95o) and Kretzsclimar and Stoddard (1964) agreed that there was a loss of mucosal rugae with age in the liumon* Wolfe, et al, (1942) found that reticular tissue which was so prom inent in the lamina propria of the rat uterus was absent from the vagina.…”

Section: Lamina Propriamentioning

confidence: 40%

“…In the uterine portion of the cervix Wolfe, et al, (1942) reported that these changes were identical to those of the uterus in which the collagenous zone of the older specimens nearly replaced the reti cular tissue. The increase in amount and density of the collagenous tissue was accelerated to the greatest extent in non-breeding rats to the extent that cervices of one year old virgins were larger than those of breeders of the same age which caused the outer lips of the cervical canals to pro ject into the vagina (Durack, et al,, 1941),…”

Section: Epitheliummentioning

confidence: 44%

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Changes with age in the canine female genitalia: histomorphological study

Stott¹

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Section: Muscularissupporting

confidence: 39%

Section: Lamina Propriasupporting

confidence: 37%

Section: Muscularismentioning

confidence: 38%

Section: Lamina Propriamentioning

confidence: 40%

Section: Epitheliummentioning

confidence: 44%

See 3 more Smart Citations

Changes with age in the canine female genitalia: histomorphological study

Stott¹

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The effects of advancing age on the structure of the anterior hypophyses and ovaries of female rats

Wolfe

1943

Am. J. Anat.

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I?VO FIGURESRecent histological observations on the anterior pituitary glands of man (Rasmussen, '36) and of rats (Wolfe, Bryan, and Wright, '38) have indicated that old age is associated with a decrease in the percentages of eosinophiles and an increase in the percentages of chromophobes. The observations on rats were concerned chiefly with a description of the adenomatous changes which occurred in the anterior lobes of the old rats, but the other structural manifestations of advancing age, particularly their progressive nature, were not considered in detail. In view of the recent interest which has been shown in the general problem of ageing, it was considered desirable to make a more detailed analysis of the progressive effects of advancing age on the structure of anterior hypophyses of rats by using a wide range of age groups which were closely spaced. Rats from the Vanderbilt strain were used for these studies, and a description of this strain has already been published (Wolfe, Bryan and Wright, '38). To eliminate the possible effects of pregnancy on the structure of the anterior hypophysis, only virgin rats were used. Since the structurg of the ovary can be considered a reliable index of the functional activity of the anterior lobe, studies were made of the ovaries in all age groups except those of rats 1 month old.

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Changes with age in the reticular fibers of the myocardium of the mouse

Bacon

1948

Am. J. Anat.

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FOURTEEN FIGURESThe importance of the fibrillar connective tissues in the economy of the body is well recognized, and it now seems evident that changes in these tissues are associated with senescence. Reticular fibers, apparently first described by Kupffer (1876) in his studies of liver, were studied in the normal, hypertrophic and diseased heart by Neuber ('12). He and later investigators found them to be present in great numbers, ensheathing individual muscle fibers as well as fiber bundles in the myocardia of all mammalian species thus f a r examined. I n a review of the literature on ageing of the heart, the only information which could be found concerning the argyrophilic reticular fibers in this organ at different ages was a brief description in a paper by Dogliotti ( '31). It is likely that qualitative or quantitative changes in them would have some effect on the functional efficiency of the organ, whether such changes were brought about by disease or were concomitants of the ageing process. A study of reticular fibers in hearts of different age groups should serve to indicate whether or not such changes occur.Studies of elastic and collagenous fibers and their changes with age have been made. Miller and Perkins ( '27) found that elastic fibers increase in number with age : the infant's myocardium contains none; by 35 years a few hare appeared among the muscle fibers, particularly in the atria ; a t 85 years many elastic fibers are present in both tlie atria and ventriculi. 469

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The effects of advancing age on the connective tissue of the uterus, cervix and vagina of the rat

Cited by 30 publications

References 3 publications

Changes with age in the canine female genitalia: histomorphological study

Changes with age in the canine female genitalia: histomorphological study

The effects of advancing age on the structure of the anterior hypophyses and ovaries of female rats

Changes with age in the reticular fibers of the myocardium of the mouse

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