The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes

Abstract

Background: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D). Methods: Forty-four males with T2D were randomly allocated to four groups (n = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 weeks. Results: Plasma dectin-1 levels were decreased in TS and TP groups compared with the CP group (p < 0.05). Cardiometabolic risk factors showed significant reductions in TP and TS groups compared to S and CP groups (p < 0.05). Conclusion: The combination of CARET and broccoli supplementation produced the largest improvements in insulin resistance and dectin-1 and other complications of T2D.

Exercise Interventions Combined With Dietary Supplements in Type 2 Diabetes Mellitus Patients—A Systematic Review of Relevant Health Outcomes

“…The selection process is presented in the flow diagram (Figure 1). Ten studies met the inclusion criteria (28)(29)(30)(31)(32)(33)(34)(35)(36)(37). The studies were published between 2006 and 2021.…”

“…Saeidi et al ( 35 ) investigated the effects of broccoli sprouts powder (B) in addition to physical training (combined AE/RT). The control groups received training + placebo, B only or placebo only.…”

“…Furthermore, the quality of the included studies was also assessed. Eight studies were assessed with 10/10 points on the PEDro scale ( 28 – 33 , 35 , 36 ), one study ( 37 ) with 7 and one study ( 34 ) with 6 points. Using the quality classification of Cashin and McAuley ( 27 ), the quality of the eight studies is rated as ‘excellent', while the quality of the two other studies is rated as ‘good’.…”

“…hs-CRP, IL-6, TNF-α and dectin-1 levels only significantly decreased in the training groups and B group. It is also important to note that Saeidi et al (35) found that TG levels significantly increased in the B group, while TG levels significantly decreased in the training groups (B + AE/RT or placebo + AE/RT).…”

SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of Diabetic Patients

“…Dysregulations in CLRs, including Dectin-1, have been associated with the development of inflammatory disorders, such as diabetes mellitus [ 19 , 20 , 21 ]. Cortez-Espinosa et al reported that abnormal expression and function of the Dectin-1 receptor in T2D patients with poor glycemic control [ 9 ].…”