The effects of aging and oxidative stress on learning behavior in C. elegans

Murakami, Shin; Murakami, Hana

doi:10.1016/j.neurobiolaging.2004.08.007

Cited by 77 publications

(67 citation statements)

References 29 publications

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“…The increased learning consistency appears common in the other lifeextending mutants (clk-1 and eat-2). Previously, we showed that reducing oxidative stress increases isothermal tracking in young adults (Murakami and Murakami, 2005), which may contribute to the learning consistency in the mutants. Interestingly, age-1 is required in a single type of interneuron, AIY, which is a key component of the thermosensory circuit.…”

Section: Discussionmentioning

confidence: 87%

“…Thus, we speculate that the effects of life extension, or improved neuronal maintenance, confer the increase in temperature-food(Ϫ) association. Importantly, oxidative stress is a determinant of levels of the steady-state temperature-food(ϩ) association (Murakami and Murakami, 2005). Thus, the results that AIY expression of age-1 restores learning behavior suggest that protecting AIY interneuron may be essential for the temperature-food(ϩ) phenotype in the Age mutants.…”

Section: Discussionmentioning

confidence: 99%

“…Isothermal tracking was determined in a single-animal assay as described previously (Murakami and Murakami, 2005). Approximately 20 adults were incubated at 15 Ϯ 0.5°C with food to learn the temperature for 18 h. Each adult was first placed on an NGM agar plate for a few minutes (typically 2 min) and then transferred to a radial thermal gradient on a 100 mm NGM agar plate for 90 min.…”

Section: Methodsmentioning

confidence: 99%

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Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans

Murakami¹,

Bessinger²,

Hellmann³

et al. 2005

J. Neurosci.

114

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Mutations in the insulin/IGF-1 neuroendocrine pathway extend lifespan and affect development, metabolism, and other biological processes in Caenorhabditis elegans and in other species. In addition, they may play a role in learning and memory. Investigation of the insulin/IGF-1 pathway may provide clues for the prevention of age-related declines in cognitive functions. Here, we examined the effects of the life-extending (Age) mutations, such as the age-1 (phosphatidylinositol 3-OH kinase) and daf-2 (insulin/IGF-1 receptor) mutations, on associative learning behavior called isothermal tracking. This thermotaxis learning behavior associates paired stimuli, temperature, and food. The age-1 mutation delayed the age-related decline of isothermal tracking, resulting in a 210% extension of the period that ensures it. The effect is dramatic compared with the extension of other physiological health spans. In addition, young adults of various Age mutants (age-1, daf-2, clk-1, and eat-2) showed increased consistency of temperature-food association, which may be caused by a common feature of the mutants, such as the secondary effects of life extension (i.e., enhanced maintenance of neural mechanisms). The age-1 and daf-2 mutants but not the other Age mutants showed an increase in temperature-starvation association through a different mechanism. Increased temperature-food association of the daf-2 mutant was dependent on neuronal Ca 2ϩ -sensor ncs-1, which modulates isothermal tracking in the AIY interneuron. Interestingly, mutations in the daf-7 TGF␤ gene, which functions in parallel to the insulin/IGF-1 pathway, caused deficits in acquisition of temperature-food and temperature-starvation association. This study highlights roles of the Age mutations in modulation of certain behavioral plasticity.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans

Murakami¹,

Bessinger²,

Hellmann³

et al. 2005

J. Neurosci.

114

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“…Previously, progressive behavioral senescence has been demonstrated in the fly Drosophila melanogaster (for review, see Grotewiel et al, 2005), the nematode Caenorhabditis elegans (Murakami and Murakami, 2005), rats (Zyzak et al, 1995), primates (Price et al, 1991) and humans (Perlmutter et al, 1981). This phenomenon appears to reflect a general pattern of life history in these species, but the progressive nature of their aging makes it difficult to separate effects of chronological aging from those of physiological aging.…”

Section: Discussionmentioning

confidence: 99%

Cognitive aging is linked to social role in honey bees (Apis mellifera)

Behrends

Scheiner

Baker

et al. 2007

Experimental Gerontology

106

136

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Aging is associated with cognitive impairment in numerous animal species. Across taxa, decline in learning performance is linked to chronological age. The honey bee (Apis mellifera), in contrast, offers an opportunity to study such aspects of aging largely independent of age per se. This is because foraging onset can be decoupled from chronological age, although workers typically first perform tasks inside the nest and later forage outside the hive. Further, early phases of foraging are characterized by growth of specific brain neuropiles, whereas late phases of the forager life-stage are accompanied by accelerated rates of physiological senescence. Yet, it is unclear if these patterns of senescence include cognitive function. The flexibility of worker ontogeny, however, suggests that the bee can become an attractive model for studies of plasticity in cognitive aging that ultimately may lead to insight into mechanisms that govern age-related cognitive decline. To address this potential, we studied effects of honey bee chronological age and of social role on sensory sensitivity and associative olfactory learning performance. Our results show a decline in olfactory acquisition performance that is linked to social role, but not to chronological age. This decline occurs only in foragers with long foraging duration, but at the same time the foragers show less generalization of odors, which is indicative of more precise learning. Foragers that are reversed from foraging to nest tasks, furthermore, do not show deficits in olfactory acquisition. These results point to complex effects of aging on associative learning in honey bees.

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“…Some authors also reported correlation of heat resistance with life span (Lithgow et al 1995;Lee and Kenyon 2009); however, in our case, we did not notice any effect on the thermal tolerance of worms by FA. Worms modify their behavior under adverse environmental conditions and also with age, leading to change in their learning and motor activities (Glenn et al 2004;Zhang et al 2005;Murakami and Murakami 2005). FA improved CI in adult day 2 worms, suggesting the ability of FA to improve health span.…”

Section: Discussionmentioning

confidence: 99%

Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans

Rathor

Akhoon

Pandey

et al. 2015

AGE

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Folic acid (FA) is an essential nutrient that the human body needs but cannot be synthesized on its own. Fortified foods and plant food sources such as green leafy vegetables, beans, fruits, and juices are good sources of FA to meet the daily requirements of the body. The aim was to evaluate the effect of dietary FA levels on the longevity of well-known experimental aging model Caenorhabditis elegans. Here, we show for first time that FA extends organism life span and causes a delay in aging. We observed that FA inhibits mechanistic target of rapamycin (mTOR) and insulin/ insulin growth factor 1 (IGF-1) signaling pathways to control both oxidative stress levels and life span. The expression levels of stress-and life span-relevant gerontogenes, viz. daf-16, skn-1, and sir. 2.1, and oxidative enzymes, such as glutathione S-transferase 4 (GST-4) and superoxide dismutase 3 (SOD-3), were also found to be highly enhanced to attenuate the intracellular reactive oxygen species (ROS) damage and to delay the aging process. Our study promotes the use of FA to mitigate abiotic stresses and other aging-related ailments.

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The effects of aging and oxidative stress on learning behavior in C. elegans

Cited by 77 publications

References 29 publications

Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans

Aging-Dependent and -Independent Modulation of Associative Learning Behavior by Insulin/Insulin-Like Growth Factor-1 Signal inCaenorhabditis elegans

Cognitive aging is linked to social role in honey bees (Apis mellifera)

Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans

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