The Effects of Aging on Local Rates of Cerebral Protein Synthesis in Rats

Ingvar, M.; Maeder, Philippe; Sokoloff, Louis; Smith, Charles J.

doi:10.1159/000409187

Cited by 2 publications

(2 citation statements)

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“…These findings in protein synthesis were similar to the age related changes in local rates of glucose utilization in rats reported earlier by Smith et al (1980). Ingvar et al (1983) suggest that the reduced protein syn thesis in sensory cortices may reflect degenerative changes in the peripheral sense organs, which in the substantia nigra may be related to decreased glu cose utilization in the caudate, and which in the locus ceruleus may be related to a depletion of neu rons in it or of their ascending catecholaminergic projections.…”

Section: Organization Of Behavior (Adaptation)-disturbed (Organiza Timentioning

confidence: 99%

Cerebral Blood Flow and Metabolism in Normal Human Aging, Pathological Aging, and Senile Dementia

Dastur

1985

J Cereb Blood Flow Metab

124

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Summary: A review and a reappraisal are presented of earlier data on cerebral circulatory and metabolic studies in normal active elderly men (Group I) of mean age 71 years, compared with normal young subjects of mean age 21 years, conducted at the National Institutes of Health, Bethesda, MD, U.S.A., during [1956][1957][1958]. There was no significant difference in the mean CBF and cerebral met abolic rate for oxygen (CMR02) values between the two populations; i.e., these important parameters did not fall with chronological aging per se. There was significant depression in the mean cerebral metabolic rate for glu cose (CMRG) value (by -23%) in the aged compared with the young. Newer methods using positron emission to mography and appropriate isotopes have confirmed these findings in normal aging in human subjects and experi mental animals. As expected, MABP and cerebral vas cular resistance (CVR) were significantly elevated in the normal aged. MABP was even more elevated in elderly hypertensive subjects, and the CVR more elevated in the subjects with arteriosclerosis (Group II), who alsoThe World Health Organization designated 1982 as "the year of the aged," in view of the global increase of the elderly population. Whereas the av erage life expectancy in India is now � 54 years, the

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Section: Organization Of Behavior (Adaptation)-disturbed (Organiza Timentioning

confidence: 99%

Cerebral Blood Flow and Metabolism in Normal Human Aging, Pathological Aging, and Senile Dementia

Dastur

1985

J Cereb Blood Flow Metab

124

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“…It has been shown that sleep plays a role in memory retention and general brain plasticity 1 . The EEG is the gold standard to detect sleep 2 . In rodents, EEG monitoring requires surgical implantation of electrodes affixed to a head-mount, after which the animal needs a period of time to recover 2 .…”

Section: Introductionmentioning

confidence: 99%

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Saré

Lemons

Torossian

et al. 2018

JoVE

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Traditionally, sleep is monitored by an electroencephalogram (EEG). EEG studies in rodents require surgical implantation of the electrodes followed by a long recovery period. To perform an EEG recording, the animal is connected to a receiver, creating an unnatural tether to the head-mount. EEG monitoring is time consuming, carries risk to the animal, and is not a completely natural setting for the measurement of sleep. Alternative methods to detect sleep, particularly in a high-throughput fashion, would greatly advance the field of sleep research. Here, we describe a validated method for detecting sleep via activity-based home-cage monitoring. Previous studies have shown that sleep assessed via this method has a high degree of agreement with sleep defined by traditional EEG-based measures. Whereas this method is validated for total sleep time, it is important to note that sleep bout duration should be assessed by an EEG which has better temporal resolution. The EEG can also differentiate rapid eye movement (REM) and non-REM sleep, giving more detail about the exact nature of sleep. Nevertheless, activity-based sleep determination can be used to analyze multiple days of undisturbed sleep and to assess sleep as a response to an acute event (like stress). Here, we show the power of this system to detect the response of mice to daily intraperitoneal injections.

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The Effects of Aging on Local Rates of Cerebral Protein Synthesis in Rats

Cited by 2 publications

References 0 publications

Cerebral Blood Flow and Metabolism in Normal Human Aging, Pathological Aging, and Senile Dementia

Cerebral Blood Flow and Metabolism in Normal Human Aging, Pathological Aging, and Senile Dementia

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

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