The effects of aging on hydromorphone-induced thermal antinociception in healthy female cats

Simon, Bradley T; Scallan, Elizabeth M.; Monteiro, Beatriz P.; Steagall, Paulo V.

doi:10.1097/pr9.0000000000000722

Cited by 7 publications

(5 citation statements)

References 53 publications

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“…In that study, hydromorphone provided a shorter duration and smaller magnitude of antinociception in the same cats at 6 months when compared with 9 and 12 months. These results suggest that 6-month-old kittens may require more frequent dosing of opioids than adults (Simon et al 2019).…”

Section: Indicationsmentioning

confidence: 82%

“…Buprenorphine may be an alternative and associated with minimal respiratory depression. The duration and magnitude of thermal antinociception after hydromorphone administration in cats was shorter and lower, respectively, in cats aged 6 months compared to 9 and 12 months of age, respectively (Simon et al 2019). In each case, the clinical response to treatment should guide dosing.…”

Section: Opioidsmentioning

confidence: 99%

“…These results suggest that 6‐month‐old kittens may require more frequent dosing of opioids than adults (Simon et al . 2019).…”

Section: Sectionmentioning

confidence: 99%

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2022 WSAVA guidelines for the recognition, assessment and treatment of pain

Monteiro

Lascelles

Murrell

et al. 2022

J of Small Animal Practice

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Animal sentience refers to the capacity of animals to feel both positive and negative emotions including that of pain. As veterinary health professionals, we have a medical and ethical duty to mitigate suffering from pain to the best of our ability. In 2014, the first Global Pain Council World Small Animal Veterinary Association (WSAVA) Guidelines for the Recognition, Assessment and Treatment of Pain was published and remains to this day one of the most relevant and widespread documents of its kind. The 2022 WSAVA Global Pain Management Guidelines evolves from the first document with updated scientific information reflecting major advances in veterinary pain medicine in the last decade. This document is designed to provide the user with easy-to-implement, core fundamentals on the successful recognition and treatment of pain in the day-to-day small animal clinical practice setting. It provides basic and practical information with an extensive reference list to guide those who want to further their knowledge on pain management. The 2022 WSAVA Global Pain Management Guidelines should be easily implemented regardless of practice setting and/or location for the promotion and advance of pain management and animal welfare. FIG 4. Peripheral sensitisation results in increased sensitivity around the lesion site. Affected patients may exhibit signs of hyperalgesia and allodynia. Adapted from Monteiro & Simon (2022). PGs Prostaglandins, NGF Nerve growth factor FIG 5. The constant noxious input (electrical signal) from the periphery to the spinal cord results in central sensitisation. Central sensitisation is the result from increased pain facilitation and decreased pain inhibition. Neuroplasticity and neuroimmune interactions also contribute to this phenomenon

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Section: Indicationsmentioning

confidence: 82%

Section: Opioidsmentioning

confidence: 99%

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2022 WSAVA guidelines for the recognition, assessment and treatment of pain

Monteiro

Lascelles

Murrell

et al. 2022

J of Small Animal Practice

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“…One study showed that age can influence thermal antinociception produced by opioids in cats. 88 Specifically, hydromorphone provided a shorter duration and smaller magnitude of antinociception in cats of 6 months of age than in the same individuals at 9 and 12 months of age. 88…”

Section: Treatment Of Pain – Analgesic Drugsmentioning

confidence: 86%

“…88 Specifically, hydromorphone provided a shorter duration and smaller magnitude of antinociception in cats of 6 months of age than in the same individuals at 9 and 12 months of age. 88…”

Section: Treatment Of Pain – Analgesic Drugsmentioning

confidence: 86%

2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats

Steagall

Robertson

Simon

et al. 2021

Journal of Feline Medicine and Surgery

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Practical relevance: Increases in cat ownership worldwide mean more cats are requiring veterinary care. Illness, trauma and surgery can result in acute pain, and effective management of pain is required for optimal feline welfare (ie, physical health and mental wellbeing). Validated pain assessment tools are available and pain management plans for the individual patient should incorporate pharmacological and non-pharmacological therapy. Preventive and multimodal analgesia, including local anaesthesia, are important principles of pain management, and the choice of analgesic drugs should take into account the type, severity and duration of pain, presence of comorbidities and avoidance of adverse effects. Nursing care, environmental modifications and cat friendly handling are likewise pivotal to the pain management plan, as is a team approach, involving the cat carer. Clinical challenges: Pain has traditionally been under-recognised in cats. Pain assessment tools are not widely implemented, and signs of pain in this species may be subtle. The unique challenges of feline metabolism and comorbidities may lead to undertreatment of pain and the development of peripheral and central sensitisation. Lack of availability or experience with various analgesic drugs may compromise effective pain management. Evidence base: These Guidelines have been created by a panel of experts and the International Society of Feline Medicine (ISFM) based on the available literature and the authors’ experience. They are aimed at general practitioners to assist in the assessment, prevention and management of acute pain in feline patients, and to provide a practical guide to selection and dosing of effective analgesic agents.

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Opioids

Simon,

Lizarraga

2024

Veterinary Anesthesia and Analgesia

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The effects of aging on hydromorphone-induced thermal antinociception in healthy female cats

Cited by 7 publications

References 53 publications

2022 WSAVA guidelines for the recognition, assessment and treatment of pain

2022 WSAVA guidelines for the recognition, assessment and treatment of pain

2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats

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