The effects of albuterol on sulfur dioxide-induced bronchoconstriction in allergic adolescents*

Koenig, Julian; Sg, Marshall; Horike, Martha; Gg, Shapiro; Ct, Furukawa; Bierman, C. Warren; We, Pierson

doi:10.1016/s0091-6749(87)80016-7

Cited by 26 publications

(5 citation statements)

References 14 publications

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“…Significant protection against MBS-induced bronchoconstriction was demonstrated by a mean 16.9-fold increase in PD35 after salbutamol 200 ,ug, and complete protection when comparing response at the highest MBS concentration achieved on placebo day. A similar degree of protection has been reported for 180 ,ug salbutamol against S02-induced bronchoconstriction (Koenig et al, 1987). ,32-adrenoceptor agonist drugs protect against induced bronchoconstriction whatever the stimulusso called physiological antagonism.…”

Section: Discussionsupporting

confidence: 72%

“…Salbutamol is a specific P2-adrenoceptor agonist which has been shown to prevent SO2 induced bronchoconstriction in adolescents (Koenig et al, 1987), but its effect on MBS induced bronchoconstriction has not been formally studied. The aim of this study was to examine the effect of inhaled salbutamol pretreatment on MBS induced bronchoconstriction.…”

Section: Introductionmentioning

confidence: 99%

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Salbutamol inhibits metabisulphite‐induced bronchoconstriction.

Iredale

Dixon

Ind

1991

Brit J Clinical Pharma

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Salbutamol inhibits metabisulphite‐induced bronchoconstriction.

Iredale

Dixon

Ind

1991

Brit J Clinical Pharma

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“…Similarly. Koenig et al [34] described the attenuating effect of sal butamol on sulfur dioxide-induced bronchoconstriction in adolescents. Likewise, salbutamol inhibits metabisulfiteinduced bronchoconstriction in atopic subjects [35].…”

Section: Discussionmentioning

confidence: 99%

Sulfur Dioxide and Sodium Metabisulfite Induce Bronchoconstriction in the Isolated Perfused and Ventilated Guinea Pig Lung via Stimulation of Capsaicin-Sensitive Sensory Nerves

Bannenberg¹,

Atzori²,

Xue³

et al. 1994

Respiration

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In this study the relationship between sulfur dioxide-induced sensory nerve activation and acute bronchoconstriction was assessed. We also studied the effects of sodium metabisulfite, an agent that is suggested to increase airway resistance via activation of sensory nerves. Sulfur dioxide (250 ppm) induced a characteristic biphasic bronchoconstriction. Concomitantly sulfur dioxide induced the release of calcitonin gene-related peptide (CGRP) from capsaicin-sensitive sensory nerves into the pulmonary circulation. In lungs of guinea pigs pretreated with a neurotoxic dose of capsaicin, the first phase of bronchoconstriction was reduced and the overflow of CGRP was not detectable. Tetrodotoxin abolished the initial phase of the bronchoconstriction induced by sulfur dioxide, indicating that a local neural reflex depending on sodium channels was operant. Inhibition of the vanilloid receptor with capsazepine slightly, although not significantly, reduced the contractile responses to sulfur dioxide. Sodium metabisulfite, when infused via the pulmonary circulation (3 mM), induced bronchoconstriction which was abolished by capsaicin pretreatment, but not significantly reduced by capsazepine. The results indicate that in the isolated guinea pig lung inhaled sulfur dioxide induces initial bronchoconstriction in part via sensory nerve activation, while other mechanisms are involved in the late effect. Sensory nerve activation appears to be the only mechanism for bronchoconstriction induced by infused sodium metabisulfite. A role for sensory nerve-mediated bronchoconstriction by sulfur dioxide or sodium metabisulfite via activation of the vanilloid receptor could not be conclusively demonstrated by this study using capsazepine.

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“…Sulpher dioxide is the chemical compound SO2 can affect both health and environment. A number of agent like cotton green dust shown to give rise to asthma like syndrome [1], [2]. Asthma-like syndrome" manifested by a decrease of pulmonary function tests and an increase of symptom scores of dyspnea and cough in apricot sulfurization workers (ASW) [3].…”

Section: Introductionmentioning

confidence: 99%

Preventive Therapy of Ipratropium Bromide in So2 Toxicity

2022

IRJMETS

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Apricot/coal refining/metal refining sulfurization human beings are uncovered to immoderate concentrations of sulfur dioxide (SO2), ensuing in an asthama like syndrome. So, ipratropium bromide can be helpful in prophylaxis therapy in sulfurization toxicity induced by SO2 during Apricot storage process. Administrating intranasal ipratropium bromide at the dose of 1.25mg/500mcg recapsule of 2.5ml is utilized for the therapy of ALS (Asthama like syndrome -a lung issue in which progression of air to the lungs is impeded).

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The effects of albuterol on sulfur dioxide-induced bronchoconstriction in allergic adolescents*

Cited by 26 publications

References 14 publications

Salbutamol inhibits metabisulphite‐induced bronchoconstriction.

Salbutamol inhibits metabisulphite‐induced bronchoconstriction.

Sulfur Dioxide and Sodium Metabisulfite Induce Bronchoconstriction in the Isolated Perfused and Ventilated Guinea Pig Lung via Stimulation of Capsaicin-Sensitive Sensory Nerves

Preventive Therapy of Ipratropium Bromide in So2 Toxicity

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