The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes

Mori, Trevor A.; Burke, Valerie; Zilkens, Renate; Hodgson, Jonathan M.; Beilin, Lawrence J.; Puddey, Ian B.

doi:10.1097/hjh.0000000000000816

Cited by 36 publications

(37 citation statements)

References 42 publications

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“…For the systematic review, we used data from 36 articles including 2865 participants, with sex-specific data from 1413 men and 113 women. 9–11,22–54 Overall, data from 2464 men and 401 women were analysed. Weighted mean age was 49·5 years and mean BMI was 27·1 kg/m 2 .…”

Section: Resultsmentioning

confidence: 99%

“…15 trials used a parallel-arm design, 9–11,22–33 and 21 used a crossover design. 34–54 13 trials provided data for people with hypertension (weighted mean systolic blood pressure 146 mm Hg), 12 had a mix of normotensives and hypertensives (weighted mean systolic blood pressure 137 mm Hg), and 13 trials provided data for normotensive people (weighted mean systolic blood pressure 122 mm Hg). The length of the trials ranged from 1 week to 2 years (median 4 weeks).…”

Section: Resultsmentioning

confidence: 99%

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The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis

Roerecke

Kaczorowski

Tobe

et al. 2017

The Lancet Public Health

405

257

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Background Although it is well established that heavy alcohol consumption increases the risk of hypertension, little is known about the effect of a reduction of alcohol intake on blood pressure. We aimed to assess the effect of a reduction in alcohol consumption on change in blood pressure stratified by initial amount of alcohol consumption and sex in adults. Methods In this systematic review and meta-analysis, we searched MedLine, Embase, CENTRAL, and ClinicalTrials. gov from database inception up to July 13, 2016, for trials investigating the effect of a change of alcohol consumption on blood pressure in adults using keywords and MeSH terms related to alcohol consumption, blood pressure, and clinical trials, with no language restrictions. We also searched reference lists of identified articles and published meta-analyses and reviews. We included full-text articles with original human trial data for the effect of a change of alcohol consumption on blood pressure in adults, which reported a quantifiable change in average alcohol consumption that lasted at least 7 days and a corresponding change in blood pressure. We extracted data from published reports. We did random-effects meta-analyses stratified by amount of alcohol intake at baseline. All meta-analyses were done with Stata (version 14.1). For the UK, we modelled the effect of a reduction of alcohol consumption for 50% of the population drinking more than two standard drinks per day (ie, 12 g pure alcohol per drink). Findings 36 trials with 2865 participants (2464 men and 401 women) were included. In people who drank two or fewer drinks per day, a reduction in alcohol was not associated with a significant reduction in blood pressure; however, in people who drank more than two drinks per day, a reduction in alcohol intake was associated with increased blood pressure reduction. Reduction in systolic blood pressure (mean difference −5·50 mm Hg, 95% CI −6·70 to −4·30) and diastolic blood pressure (−3·97, −4·70 to −3·25) was strongest in participants who drank six or more drinks per day if they reduced their intake by about 50%. For the UK, the results would translate into more than 7000 inpatient hospitalisations and 678 cardiovascular deaths prevented every year. Interpretation Reducing alcohol intake lowers blood pressure in a dose-dependent manner with an apparent threshold effect. Implementation of effective alcohol interventions in people who drink more than two drinks per day would reduce the disease burden from both alcohol consumption and hypertension, and should be prioritised in countries with substantial alcohol-attributable risk. Funding National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health (NIH).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis

Roerecke

Kaczorowski

Tobe

et al. 2017

The Lancet Public Health

405

257

View full text Add to dashboard Cite

show abstract

“…In a controlled trial in persons with Type 2 diabetes mellitus, that compared red wine with dealcoholized red wine (DRW) and water, we showed that red wine increased awake systolic and diastolic blood pressure and heart rate relative to water and DRW, without affecting glycemic control [15]. In a trial of similar design in healthy men we showed that consumption of alcohol as red wine increased plasma SPM levels [13].…”

Section: Introductionmentioning

confidence: 85%

“…In this report we aimed to examine the effects of red wine on plasma SPM in plasma samples collected from the same randomised controlled trial of red wine in patients with Type 2 diabetes mellitus [15]. In addition, we compared plasma SPM levels in patients with Type 2 diabetes mellitus with those of healthy volunteers.…”

Section: Introductionmentioning

confidence: 99%

The effects of alcohol on plasma lipid mediators of inflammation resolution in patients with Type 2 diabetes mellitus

Barden

Shinde

Phillips

et al. 2018

Prostaglandins, Leukotrienes and Essential Fatty Acids

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“…The characteristics of the included studies are detailed in the following Tables 3-5. The studies were separated according to mineralization of the water and the control group: Table 3: RCTs comparing water with other drinks or no drink (eight studies); [17][18][19][20][21][22][23][24]. Table 4: RCTs comparing low mineralized with bicarbonate-rich water (five studies); [25][26][27][28][29].…”

Section: Description Of Included Studiesmentioning

confidence: 99%

Prevention and Therapy of Type 2 Diabetes-What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

Naumann

Biehler²,

Lüty³

et al. 2018

Bol Soc Esp Hidrol Med

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We aim to present an overview of the possible influence of drinking water in general and mineral water in particular in improving glycemic parameters in persons with or without type 2 diabetes. We performed a literature search that produced 15 randomized controlled trials (RCTs) on this topic with mainly small sample sizes. We also discuss relevant observational and animal studies as well as the effects of important supplements in mineral water such as hydrogencarbonate and magnesium. There is low evidence for the positive effects of water or mineral water in improving glycemic parameters in diabetic and non-diabetic persons, and the results are heterogenous, making it difficult to reach an unequivocal conclusion. Meta-analyses of prospective cohort studies and other observational studies, studies with animal models and interventional studies using hydrogencarbonate and magnesium supplements suggest a probable positive effect of drinking water and mineral water in particular on glycemic parameters, supporting the positive results found in some of the RCTs, especially those substituting diet beverages or caloric beverages with water, or those using bicarbonate and magnesium-rich water. Regarding the high prevalence, the associated suffering and the resulting health expenditures of type 2 diabetes, it is imperative to conduct larger and more rigorous trials to answer the question whether drinking water or mineral water can improve glycemic parameters in diabetic and non-diabetic persons.People who don't drink sugar sweetened beverages tend to have higher quality diets and do not compensate for sugar or energy deficits by consuming more sugary foods [7].A nutrition survey examining the relationship between the quantity of water taken in and HbA1c in 1035 participants calculated that an increase of 240 mL in daily water intake reduces the risk of elevated HbAc1 >5.5% by 22% in men but not in women [8].A review of 134 randomized controlled trials (RCTs), where water consumption was increased right before or during a meal, showed heterogenic effects on energy intake, energy expenditure, fat oxidation and weight change [9].Moreover, mineral nutrients such as bicarbonate [10] and magnesium [11], in particular, are thought to affect glucose metabolism. An increased dietary acid load is associated with the development of insulin resistance [12], while a pre-existing diabetes favors acidosis, which, in turn, leads to increased insulin resistance [13].Drinking recommendations are less common and detailed than food recommendations [3,14], and there is little scientific evidence, and, to our knowledge, no review of RCTs on drinking water and its influence on glycemic parameters, respectively type 2 diabetes.This review aims to explore to what extent drinking water with low or high mineralization for at least four weeks influences glycemic parameters in healthy or type 2 diabetes participants in daily life situations as compared with other drinks. The results of the RCTs found in the literature search will be discussed alongsid...

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The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes

Abstract: In well controlled type 2 diabetic individuals 24-31 g alcohol/day (∼2-3 standard drinks) raises awake BP and 24-h HR and lowers asleep BP but does not otherwise favourably or adversely modify cardiovascular risk factors.

Cited by 36 publications

References 42 publications

The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis

The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis

The effects of alcohol on plasma lipid mediators of inflammation resolution in patients with Type 2 diabetes mellitus

Prevention and Therapy of Type 2 Diabetes-What Is the Potential of Daily Water Intake and Its Mineral Nutrients?

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