“…38 Nonmetal alloplastic materials such as MEDPOR (Porex, Newnan, GA), Proplast porous hydroxyapatite (Novamed, Chicago, IL), bioactive glasses, and silicone are also available, all having significant limitations, making them less suitable for reconstruction of large contour deformities. 36,40,41 Polymethylmethacrylate was developed in 1939 and first used by Kleinschmidt in 1940 in a rabbit cranioplasty model. Zander and later Gurdjian were the first surgeons to use PMMA in humans.…”