The effects of allopurinol, uric acid, and inosine administration on xanthine oxidoreductase activity and uric acid concentrations in broilers

Settle, Tabatha; Carro, M. D.; Falkenstein, E.; Radke, W.J.; Klandorf, H.

doi:10.3382/ps.2012-02321

Cited by 14 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liver samples were collected to study the antioxidant activity by estimating the superoxide dismutase (SOD) (Marklund and Marklund, 1974), catalase (CAT) (Claiborne, 1985) and total reduced glutathione (GSH) content (Ellmans, 1959) in double beam UV/ Visible spectrophotometer. Also liver tissues were frozen in liquid nitrogen for the estimation of xanthine oxidase activity (Settle et al 2012). Experimental data was statistically analyzed in complete randomized design (Snedecor and Cochran, 2004)…”

Section: Methodsmentioning

confidence: 99%

Assessment of Antigout, Antioxidant and Production Performance Augmenting Activity of Piper betle L. in Gout Induced Broiler Chicken

Periasamy

Sundaravelayutham

Arivalagan

et al. 2021

IJAR

View full text Add to dashboard Cite

Background: The gout is commonly reported in birds and causes severe economic losses to the farmers. Hence to prevent the gout occurrence P.betle L. herb was selected and its antigout potential was studied in comparison with Allopurinol.Methods: The biological experiment was conducted with 120 broiler chicks and was divided into 5 treatment groups of 8 birds each with triplicate study for six weeks. The groups were control (T1), gout control (T2), Allopurinol (T3), P.betle L. - 10 g/kg (T4) and P.betle L. - 12.5 g/kg of feed (T5). The gout was induced using toxic dose of sodium bicarbonate in water (20 g/litre). The clinical signs and production performance were recorded and gross and histopathology studies were conducted. Serum biochemical parameters viz., uric acid and creatinine were periodically estimated (day 10, 15, 18 and 42 of trial) and anti-oxidant and xanthine oxidase enzyme activity were measured.Result: The production performances and the antioxidant activity were improved in P.betle L. groups and even better than Allopurinol. Also progressive reduction of uric acid and equivalent suppression of xanthine oxidase activity as that of Allopurinol were observed. Hence P.betle L. herb can be used effectively in the prevention of gout in birds.

show abstract

Section: Methodsmentioning

confidence: 99%

Assessment of Antigout, Antioxidant and Production Performance Augmenting Activity of Piper betle L. in Gout Induced Broiler Chicken

Periasamy

Sundaravelayutham

Arivalagan

et al. 2021

IJAR

View full text Add to dashboard Cite

show abstract

“…In broilers, uricemia was reduced as well as xanthine oxidase and xanthine dehydrogenase activity in the kidney in birds treated with allopurinol (25 mg/kg by mouth). 24,25 Allopurinol was unable to completely inhibit xanthine oxidoreductase activity. 24 Toxicity has been reported following administration of allopurinol in red-tailed hawks (Buteo jamaicensis).…”

Section: Xanthine Oxidase Inhibitorsmentioning

confidence: 98%

“…24,25 Allopurinol was unable to completely inhibit xanthine oxidoreductase activity. 24 Toxicity has been reported following administration of allopurinol in red-tailed hawks (Buteo jamaicensis). Vomiting developed at 50 mg/kg by mouth every 24 hours and was attributed to the accumulation of oxypurinol, a metabolite that worsens renal gout.…”

Section: Xanthine Oxidase Inhibitorsmentioning

confidence: 98%

Clinical Management of Avian Renal Disease

Cojean

Larrat

Vergneau‐Grosset

2020

Veterinary Clinics of North America: Exotic Animal Practice

View full text Add to dashboard Cite

“…The berberine group (BRB) was supplemented with berberine (200mg/kg of feed) 14 , the ALLO group was provided allopurinol (25mg/kg of body weight) supplemented in the diet 24 , in addition to a CLA+ALLO and BRB+ALLO group where ALLO was provided for the last two weeks of the study. The ALLO, CLA+ALLO and BRBA+ALLO were treated with allopurinol to induce a redox state 25,26 . Weights were recorded weekly over the six-week experimental period.…”

Section: Experimental Designmentioning

confidence: 99%

The Effects of Conjugated Linoleic Acid and Berberine Supplementation on Markers of Allopurinol Activated Oxidative Stress in Broiler Chickens

Dartigue

Dyke

Klandorf

et al. 2021

MRAJ

View full text Add to dashboard Cite

Selection for rapid growth in poultry can be linked to an exaggerated state of oxidative stress (reactive oxidative species). Reactive oxidative species are kept in balance by endogenous and exogenous antioxidants. Two compounds, conjugated linoleic acid (CLA) and berberine a purified compound from plant root extract have been suggested to ameliorate oxidative stress. A six-week study examined the effect of CLA and berberine supplementation on markers of oxidative-stress in poultry. Day old broiler chickens (n=60) were equally divided into six groups; a control, a CLA group where half of the regular oil used in a standard was substituted for a CLA oil mixture, a berberine group consisting of berberine supplementation, an allopurinol group, a CLA and allopurinol with the same dose as the CLA and allopurinol groups and a berberine and allopurinol group. The allopurinol was added to induce an oxidative stress state. Body weight, plasma uric acid, plasma glucose, and relative gene expression of six endogenous liver antioxidants were measured during the course of the study. The addition of allopurinol to the diet induced an oxidative stress state as measured by a significant reduction in plasma uric acid. There were no significant changes in BW and blood glucose concentrations. There was a 10-fold increase in the relative mRNA expression of superoxide dismutase 2 and 3 as well as glutathione peroxidase 1 and 3 in CLA+ALLO and BRB+ALLO treatment groups. Notably, CLA increased the expression of uncoupling protein 19-fold compared to control, while the addition of allopurinol blocked these changes. In contrast, there was a slight increase in the uncoupling protein in the BRB+ALLO treatment. Despite the increase in mRNA expression of the antioxidants genes, these results suggest that at the dosages administered, CLA and berberine were not effective in reversing the oxidative stress induced by allopurinol.

show abstract

The effects of allopurinol, uric acid, and inosine administration on xanthine oxidoreductase activity and uric acid concentrations in broilers

Cited by 14 publications

References 23 publications

Assessment of Antigout, Antioxidant and Production Performance Augmenting Activity of Piper betle L. in Gout Induced Broiler Chicken

Assessment of Antigout, Antioxidant and Production Performance Augmenting Activity of Piper betle L. in Gout Induced Broiler Chicken

Clinical Management of Avian Renal Disease

The Effects of Conjugated Linoleic Acid and Berberine Supplementation on Markers of Allopurinol Activated Oxidative Stress in Broiler Chickens

Contact Info

Product

Resources

About