The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation - a study in healthy well-trained individuals after intensive resistance and endurance training

Isenmann, Eduard; Trittel, Lucas; Diel, Patrick

doi:10.1186/s12970-020-00389-y

Cited by 16 publications

(14 citation statements)

References 68 publications

(93 reference statements)

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“…Regarding performance outcomes, a significant decrease was observed in 1RM but not in CMJ. The results of 1RM are confirmed with observations of previous studies [1,3,52,56]. However, the decrease in performance in the CBD group is smaller than that in the pilot study [52].…”

Section: Discussionsupporting

confidence: 89%

“…The results clearly show an increase in CK and Myo concentration in both groups at all time points (T24, T48, T72) with significant differences between the groups at T72 (ES: CK = −0.236, Myo = −0.214). The exercise induced muscle damage and the increase in CK and Myo concentration after T24 confirms observations from previous studies [1][2][3]52]. However, a single supplementation of CBD did not reduce muscle damage within 48 h. A longer time interval of at least 72 h, however, might be sufficient for effects of CBD to occur to detectable extend.…”

Section: Discussionsupporting

confidence: 88%

“…Intense training and performance result in damage and inflammation of the skeletal muscles [1][2][3]. Consequently, the performance of the trained skeletal muscles decreases after the intensive training sessions and needs time to recover [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

et al. 2021

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Cannabidiol supplements (CBD) are increasingly consumed by athletes to improve regeneration. However, the evidence for the pro-regenerative effects of CBD in sports is quite limited. Therefore, our aim was to investigate the effects of a single CBD supplementation in a six-arm placebo-controlled crossover study after resistance training on performance and muscle damage. Before and after the resistance training, one-repetition maximum in the back squat (1RM BS), countermovement jump (CMJ), and blood serum concentrations of creatine kinase (CK) and myoglobin (Myo) were measured in healthy, well-trained participants. Sixteen of 21 participants completed the study and were included in the analysis. In 1RM BS, a significant decrease was observed after 24 h (p < 0.01) but not 48 or 72 h. A significant group difference was detected after 72 h (p < 0.05; ES = 0.371). In CMJ, no significant changes were observed. The CK and Myo concentrations increased significantly after 24 h (CK: p < 0.001; Myo: p < 0.01), 48 h (CK: p < 0.001; Myo: p < 0.01) and 72 h (CK: p < 0.001; Myo: p < 0.001). After 72 h, a significant group difference was observed in both muscle damage biomarkers (CK: p < 0.05 ES = 0.236; Myo: p < 0.05; ES = 0.214). The results show small and significant effects on muscle damage and recovery of squat performance after 72 h. However, more data are necessary for clearer statements about the pro-regenerative effects of CBD supplementation after resistance training.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

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Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

et al. 2021

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“…The utilization of α-lipoic acid in dietary supplements is increasing due to its antioxidant and anti-diabetic properties (Lee et al 2009 ). Along with that, it ameliorates age-related cognition, diabetes mellitus, cardiovascular and erectile dysfunction, neuromuscular loss, and cancer (Wollin and Jones 2003 ; Isenmann et al 2020 ). In addition, it adjusts various signaling pathways of inflammation (Suh et al 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention

Tripathi

Ray

Mishra

et al. 2023

Rev. Bras. Farmacogn.

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Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and animals. As a potent antioxidant and a natural dithiol compound, it performs a crucial role in mitochondrial bioenergetic reactions. A healthy human body, on the other hand, can synthesize enough α-lipoic acid to scavenge reactive oxygen species and increase endogenous antioxidants; however, the amount of α-lipoic acid inside the body decreases significantly with age, resulting in endothelial dysfunction. Molecular orbital energy and spin density analysis indicate that the sulfhydryl (-SH) group of molecules has the greatest electron donating activity, which would be responsible for the antioxidant potential and free radical scavenging activity. α-Lipoic acid acts as a chelating agent for metal ions, a quenching agent for reactive oxygen species, and a reducing agent for the oxidized form of glutathione and vitamins C and E. α-Lipoic acid enantiomers and its reduced form have antioxidant, cognitive, cardiovascular, detoxifying, anti-aging, dietary supplement, anti-cancer, neuroprotective, antimicrobial, and anti-inflammatory properties. α-Lipoic acid has cytotoxic and antiproliferative effects on several cancers, including polycystic ovarian syndrome. It also has usefulness in the context of female and male infertility. Although α-lipoic acid has numerous clinical applications, the majority of them stem from its antioxidant properties; however, its bioavailability in its pure form is low (approximately 30%). However, nanoformulations have shown promise in this regard. The proton affinity and electron donating activity, as a redox-active agent, would be responsible for the antioxidant potential and free radical scavenging activity of the molecule. This review discusses the most recent clinical data on α-lipoic acid in the prevention, management, and treatment of a variety of diseases, including coronavirus disease 2019. Based on current evidence, the preclinical and clinical potential of this molecule is discussed. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s43450-023-00370-1.

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“…To counteract an inflammatory response, the supplementation of substances and antioxidant capabilities is practiced after physical exercise. One of these substances is alpha-lipoic acid (ALA) (18), which is a well-known supplement for preventing or delaying oxidative stress and inflammation. Intense resistance training has been proposed as an effective treatment in T2DM, and the most important factor in the volume of exercise in metabolic control and cardiac function (19,20).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Effect of Resistance Training and Alpha Lipoic Acid on Beclin-1 Expression and Malondialdehyde Level of Fatty Liver Diabetic Male Rats

2021

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Background: Autophagy is a genetically and evolutionarily conserved programmed process that destroys long-lived cellular proteins and organelles. Objectives: The aim of this study was to evaluate the effect of eight weeks of strength training with alpha-lipoic acid supplementation on Becline-1 and malondialdehyde concentrations in elderly diabetic rats. Methods: In this experimental study, 35 old male Wistar rats were randomly divided into five groups (healthy control, diabetic, diabetic + strength training, diabetic + supplement, diabetic + strength training + supplement). At first, the rats became diabetic and had fatty liver. Then strength training program was performed in eight weeks. Alpha-lipoic acid supplement was also injected three days a week. At the end of the training period, tissues were removed, and the expression of Becline-1 was measured by RT-PCR, and malondialdehyde concentration was measured by TBA laboratory method. For data analysis, a one-way analysis variance test was used for between-groups comparison (P < 0.05). Results: The results showed that strength training program and in combination with alpha-lipoic acid (ALA) supplementation significantly reduced Becline-1 (P = 0.001) and malondialdehyde compared to the healthy and diabetic control groups (P = 0.000). Conclusions: Strength exercise combined with ALA supplementation has a significant role in reducing the rate of autophagy and can reduce fatty liver in elderly type 2 diabetic rats.

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The effects of alpha lipoic acid on muscle strength recovery after a single and a short-term chronic supplementation - a study in healthy well-trained individuals after intensive resistance and endurance training

Cited by 16 publications

References 68 publications

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

Effects of Cannabidiol Supplementation on Skeletal Muscle Regeneration after Intensive Resistance Training

Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention

Simultaneous Effect of Resistance Training and Alpha Lipoic Acid on Beclin-1 Expression and Malondialdehyde Level of Fatty Liver Diabetic Male Rats

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