The Effects of Aminoguanidine, Methylprednisolone, and Melatonin on Nerve Recovery in Peripheral Facial Nerve Neurorrhaphy

Abstract

Aminoguanidine and melatonin alone achieved an increase in regeneration after peripheral facial nerve neurorrhaphy, but methylprednisolone did not. The best healing was determined in the AG group.

The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model

“…In a study conducted by Karlidag et al [30], the facial nerves of 30 rabbits were resected, the free ends were anastomosed, and the effects of methylprednisolone and aminoguanidine on facial nerve regeneration were studied. The study showed that methylprednisolone had no beneficial effect in nerve regeneration, even increased degeneration [2,11,30].…”

“…Many different treatments have been described for the treatment of TPFNP, including aminoguanidine, melatonin, Vitamin E, and N-acetylcystein, due to their antioxidant and anti-inflammatory properties [2,29,30]. Therefore, agents with antioxidant and anti-inflammatory properties may help treat traumatic nerve palsy.…”

“…Innervation of all muscles involved in facial expression is controlled by the facial, or seventh cranial nerve [1,2]. Facial nerve paralysis is the most commonly encountered cranial neuropathy, and develops for various reasons [3].…”

The Role of Pharmacological Agents in Nerve Regeneration after Peripheral Nerve Repair

“…Furthermore, it is worth mentioning that Turgut et al have experimentally demonstrated in rats that melatonin prevents neuroma formation after transacting the sciatic nerve by enhancing axonal regeneration [118]. Recently, some studies have shown the positive effect of melatonin on preventing scar formation, increasing nerve regeneration and improving functional recovery [119,120]. However, the exact mechanisms by which melatonin limits fibrosis are currently unclear.…”

Untitled

“…44 These researchers compared the effects of aminoguanidine, MLT, and methylprednisolone; MLT supported regeneration after peripheral facial nerve neurorrhaphy. 45 Administrating MLT after stripping of the epineural vessels in a model of sciatic nerve injury supported axonal regeneration, reduced oxidative stress, and improved functional recovery. 46 More recently, Moretti et al demonstrated for the first time that MLT reduces injury to the blood-brain barrier after an excitotoxic insult and their results were supported by gene analyses.…”