The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity

Jaeger, Xavier De; Bishop, Stephanie F.; Ahmad, Tasha; Lyons, Danika C.A.; Ng, Garye Ami; Laviolette, Steven R.

doi:10.1007/s00213-012-2852-4

Cited by 24 publications

(23 citation statements)

References 33 publications

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“…However, although both electrical stimulation of the NI and CRF infusion into the NI produced inhibition of mPFC activity, the current study does not exclude the possibility that CRF diffused to other structures. The mPFC in the rodent is implicated in a variety of cognitive processes such as spatial memory, possibly as a function of working memory, consolidation of long‐term memory, memory retrieval (Granon & Poucet, ; Seamans et al ., ; Delatour & Gisquet‐Verrier, ; Laroche et al ., ), expression of conditioned fear memory (Burgos‐Robles et al ., ) and drug addiction (see Lüscher & Malenka, for a review; De Jaeger et al ., ). It is possible that the inhibition of neurons in the mPFC, due to CRF infusion/electrical stimulation of the NI, affects these cognitive processes.…”

Section: Discussionmentioning

confidence: 97%

Corticotropin‐releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo‐medial prefrontal cortical long‐term potentiation

Farooq

Rajkumar

Srivastav

et al. 2013

Eur J of Neuroscience

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The medial prefrontal cortex (mPFC) in the rat has been implicated in a variety of cognitive processes, including working memory and expression of fear memory. We investigated the inputs from a brain stem nucleus, the nucleus incertus (NI), to the prelimbic area of the mPFC. This nucleus strongly expresses corticotropin-releasing factor type 1 (CRF1 ) receptors and responds to stress. A retrograde tracer was used to verify connections from the NI to the mPFC. Retrogradely labelled cells in the NI expressed CRF receptors. Electrophysiological manipulation of the NI revealed that stimulation of the NI inhibited spontaneous neuronal firing in the mPFC. Similarly, CRF infusion into the NI, in order to mimic a stressful condition, inhibited neuronal firing and burst firing in the mPFC. The effect of concurrent high-frequency stimulation of the NI on plasticity in the hippocampo-prelimbic medial prefrontal cortical (HP-mPFC) pathway was studied. It was found that electrical stimulation of the NI impaired long-term potentiation in the HP-mPFC pathway. Furthermore, CRF infusion into the NI produced similar results. These findings might account for some of the extra-pituitary functions of CRF and indicate that the NI may play a role in stress-driven modulation of working memory and possibly other cognitive processes subserved by the mPFC.

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Section: Discussionmentioning

confidence: 97%

Corticotropin‐releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo‐medial prefrontal cortical long‐term potentiation

Farooq

Rajkumar

Srivastav

et al. 2013

Eur J of Neuroscience

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“…Nevertheless, the VTA also sends DAergic projections directly to the mPFC [41], [42]. In addition, glutamatergic hypofunction directly in the mPFC potentiates opiate-related reward memory through DA-dependent substrates [15], [43] and modulation of mPFC neuronal activity via ascending BLA inputs is dependent upon DAergic signaling [44]. However, in these cases, DAergic modulation of emotionally salient memory is dependent upon functional BLA inputs, consistent with the current findings demonstrating that the BLA represents a first-order neural substrate for the processing of opiate-related associative memory.…”

Section: Discussionmentioning

confidence: 99%

Early versus Late-Phase Consolidation of Opiate Reward Memories Requires Distinct Molecular and Temporal Mechanisms in the Amygdala-Prefrontal Cortical Pathway

et al. 2013

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The consolidation of newly acquired memories involves the temporal transition from a recent, less stable trace to a more permanent consolidated form. Opiates possess potent rewarding effects and produce powerful associative memories. The activation of these memories is associated with opiate abuse relapse phenomena and the persistence of compulsive opiate dependence. However, the neuronal, molecular and temporal mechanisms by which associative opiate reward memories are consolidated are not currently understood. We report that the consolidation of associative opiate reward memories involves a temporal and molecular switch between the basolateral nucleus of the amygdala (BLA) (early consolidation phase) to the medial prefrontal cortex (mPFC) (late consolidation phase). We demonstrate at the molecular, behavioral and neuronal levels that the consolidation of a recently acquired opiate reward memory involves an extracellular signal-related kinase (ERK)-dependent phosphorylation process within the BLA. In contrast, later-stage consolidation of a newly acquired memory is dependent upon a calcium-calmodulin-dependent (CaMKII), ERK-independent, mechanism in the mPFC, over a 12 hr temporal gradient. In addition, using in vivo multi-unit neuronal recordings in the mPFC, we report that protein synthesis within the BLA modulates the consolidation of opiate-reward memory in neuronal mPFC sub-populations, via the same temporal dynamic.

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“…In the VTA, the opioids can recruit dopamine cells through a disinhibitory mechanism (Johnson and North, 1992;Jalabert et al, 2011). While some authors observed no significant correlation between the VTA antero-posterior placement of morphine injection and the resulting place conditioning (De Jaeger et al, 2013), data from other groups support the idea that opioids can have different behavioral consequences depending on the anteroposterior level within the VTA (Zangen et al, 2002;Jhou et al, 2012). Indeed, endomorphin-1 (EM-1) induces intracranial self-administration, conditioned place preference and increases locomotor activity when administered into the pVTA (Zangen et al, 2002;Terashvili et al, 2004) (Fig.…”

Section: Opioidsmentioning

confidence: 96%

The antero-posterior heterogeneity of the ventral tegmental area

et al. 2014

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The effects of AMPA receptor blockade in the prelimbic cortex on systemic and ventral tegmental area opiate reward sensitivity

Cited by 24 publications

References 33 publications

Corticotropin‐releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo‐medial prefrontal cortical long‐term potentiation

Corticotropin‐releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo‐medial prefrontal cortical long‐term potentiation

Early versus Late-Phase Consolidation of Opiate Reward Memories Requires Distinct Molecular and Temporal Mechanisms in the Amygdala-Prefrontal Cortical Pathway

The antero-posterior heterogeneity of the ventral tegmental area

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