The effects of analgesic drugs on gastro-intestinal motility in man

Neely, Julian

doi:10.1002/bjs.1800561215

Cited by 24 publications

(6 citation statements)

References 21 publications

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“…It is well established in animals that postoperative ileus results from sympathetic inhibition mediated by a spinal reflex and this is generally accepted as being also true for man (1,11,19,34,44). The present study brings further indications about the mechanisms of paralytic ileus.…”

Section: Commentsmentioning

confidence: 69%

Gastrointestinal Myoelectrical Activity during the Postoperative Period in Man

Dauchel¹,

Schang²,

Kachelhoffer³

et al. 1976

Digestion

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Myoelectrical activity of the gastrointestinal tract has been studied in the postoperative period of 13 patients who underwent cholecystectomy. The recordings have been performed by means of extracellular electrodes which were implanted at the levels of stomach, jejunum, ileum and colon during the surgical procedure. The records showed that fast activity is always persistent while the basic electrical rhythm is greatly disorganized during the immediate postoperative period. Such a characteristic pattern of the electrical activity suggested that the lack of peristaltic and propulsive movements, always noted during this period, is not correlated with a disappearance of gastrointestinal contractions, but only with a disturbance in their coordination.

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Section: Commentsmentioning

confidence: 69%

Gastrointestinal Myoelectrical Activity during the Postoperative Period in Man

Dauchel¹,

Schang²,

Kachelhoffer³

et al. 1976

Digestion

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“…It has been repeatedly stated in the past that the duration of postoperative ileus is proportional to the severity of the surgical trauma and also to the type of operation (Neely, 1969;Aird, 1957). It was therefore surprising to find that the length of operation had little or no effect on the duration of colonic stasis in this series.…”

Section: Discussionmentioning

confidence: 98%

Postoperative motility of the large intestine in man.

Wilson¹

1975

Gut

139

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SUMMARY Motor activity of the colon in the immediate postoperative period has been studied in human subjects using radiotelemetering capsules, radioopaque markers and serial abdominal radiographs.Following operations outside the abdomen there is a delay of about 16 hours before colonic activity returns. After abdominal operations the delay is from 40 to 48 hours.The length of an operation has no significant effect upon the duration of colonic ileus. The amount of postoperative analgesia has no significant effect upon the duration of colonic ileus. Gaseous distension after laparotomy is confined to the colon.It is well recognized that following operation the motility of the gastrointestinal tract is temporarily impaired. At times this is more prolonged and, if associated with gaseous distension, develops into paralytic ileus. It has been shown in experimental animals that the activity of the small intestine returns to normal within a few hours following surgery (Tinckler, 1965;Baker and Webster, 1968). Early return of activity has also been shown in man using a radiotelemetering capsule (Ross, Watson, and Kay, 1963 (Nachlas, Younis, Roda, and Wityk, 1972;Neely, 1968). Most of these studies have been radiological observations of barium in the gastrointestinal tract, and, althoughthestudies have been primarily directed at the stomach, most workers have observed that barium is also held up in the colon. Study of the colon has not been taken further than this one observation.The present study investigates in more detail the motor behaviour of the colon in the postoperative

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“…The severity of gastrointestinal hypomotility is related to the extent of surgical manipulation and subsequent inflammatory response in sheep, 35 humans, 36 and laboratory animals. 15,37 It is therefore likely that minimization of mechanical manipulation to the abomasum, small intestine, and omentum during the laparoscopy-guided procedure is the main reason for the difference in abomasal emptying rate detected between surgical groups in the present study.…”

Section: Discussionmentioning

confidence: 99%