The Effects of Angelica ternata Extract from Kyrgyzstan on the Formation of Candida albicans ATCC 10231 Biofilms

Abstract

The therapeutic potential of Angelica ternata extract was tested against biofilm-associated fungi Candida albicans. Such an extract with a 1.896 ± 0.071% per 1 mL rutin content of flavonoids can reliably suppress the formation of biofilms of pathogenic yeast-like fungi up to 76.6%. The herbal medicine has a significant effect on the initiation, adhesion, and development of biofilms. If the extract is added to a developed biofilm, it has a significant effect on the matrix. As a result, the “glue” between the cells is washed out and they are more easily washed away from the well of the microplate to which they are attached. In this case, the optical density of the biofilm is halved (50.5%).

The Influence of L-Lysine-Alpha-Oxidase on the Biofilm Formation of Opportunistic Microorganisms Associated with Inflammatory Diseases of the Urinary Tract

“…There are probably other signaling molecules and a different matrix composition, and the enzyme may have difficulty penetrating the fungal cell, which has a more rigid cell wall. Moreover, in representatives of the genus Candida , during the formation of biofilms, processes that differ from those observed for bacteria are described; for example, during adhesion, these fungi form microtubules and synthesize many enzymes for the penetration and destruction of the cell walls of eukaryotes [ 27 , 28 , 29 ]. It is theoretically possible that these aggressive Candida enzymes can destroy or inactivate the enzyme L-lysine-α-oxidase or that the chitinous layer is too tough for LO.…”

The Development of a Method for Obtaining Tripleurospermum inodorum (L.) Sch. Bip. Herb Extract Enriched with Flavonoids and an Evaluation of Its Biological Activity

“…The degree of sensitivity of microorganisms to the test samples was determined by the size of the zone of no growth of microorganisms. Microbiological studies were carried out in laminar, pre-irradiated with a UV lamp for sterilization before sowing test cultures on nutrient media [ 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”