The effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model

Özay, Rafet; Yavuz, Osman Yüksel; Türkoğlu, Mehmet Erhan; Aktaş, Abit; Yigit, Funda; Özdemir, Hacı Mustafa; Şekerci, Zeki

doi:10.1590/s0102-865020150120000002

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Studies conducted with hemostats or adhesion inhibitors in the literature reported that EF formation was reduced. Ozay et al [20] In the fibrillar group, the IL-6 (1/10³) level was 0.24 ± 0.31, which was significantly lower than that in the control and bipolar groups (p = 0.022). There was no significant difference in the IL-6 level between the control and bipolar groups (p = 0.142).…”

Section: Groupmentioning

confidence: 90%

Comparison of the effect of bipolar coagulation and fibrillar structured oxidized cellulose on formation epidural fibrosis in rats

Çetin¹,

Eren²,

Güzey³

et al. 2021

Turk J Med Sci

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The number of epidural fibroblasts, percentage of modified Lubina, amount of IL-6, and He grading rates were significantly lower in the fibrillar group than in the bipolar and control groups (p ˂ 0.05). On the other hand, there was no significant difference among the control, fibrillar, and bipolar groups in terms of TGFβ-1 values (p= 0.525). Conclusion:The use of fibrillar oxidized cellulose was more effective for hemostasis than bipolar coagulation in reducing the development of EF.

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Section: Groupmentioning

confidence: 90%

Comparison of the effect of bipolar coagulation and fibrillar structured oxidized cellulose on formation epidural fibrosis in rats

Çetin¹,

Eren²,

Güzey³

et al. 2021

Turk J Med Sci

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“…Excessive production of fibrosis at the postoperative epidural bed can cause neural irritation or stretching, and sometimes even mass effects, resulting in radicular symptoms. [44][45][46] Therefore, avoiding or at least minimizing epidural scarring can improve postoperative clinical outcomes. Although it is impossible to completely prevent epidural scarring, efforts made to minimize this phenomenon in laminectomies 47,48 have demonstrated the clinical significance of ligamentum flavum preservation and support the use of endoscopic spine surgeries to minimize epidural scarring through minimizing the extent of laminectomies and ligamentum flavum resection.…”

Section: Discussionmentioning

confidence: 99%

Full Endoscopic Ligamentum Flavum Sparing Unilateral Laminotomy for Bilateral Recess Decompression: Surgical Technique and Clinical Results

et al. 2022

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Objective: Interlaminar endoscopic spine surgery has been introduced and utilized for lumbar lateral recess decompression. We modified this technique and utilized it for bilateral lateral recess stenoses without significant central stenosis. Here we present the surgical details and clinical outcome of ligamentum flavum sparing unilateral laminotomy for bilateral recess decompression (ULBRD).Methods: Prospectively collected registry for full-endoscopic surgeries was reviewed retrospectively. One hundred eighty-two consecutive cases from a single center between September 2015 and March 2021 were reviewed and 57 of them whom underwent ULBRD were enrolled for analysis. Basic patient demographic data, perioperative details, surgeryrelated complications, and clinical outcome were reviewed. The detailed surgical technique is presented as well.Results: Among the 57 patients enrolled, 37 were males while the other 20 were females. The mean age was 58.53 ± 14.51 years, and a bimodal age distribution at the age of mid-fifties and mid-sixties or older was noted. The later age-peak was related to coexistence of degenerative scoliosis. The average operative time per lamina was 70.34 ± 20.51 minutes and mean length of stay was 0.56 ± 0.85 days. Four perioperative complications were reported (7.0%) and the overall reoperation rate at the index level within 1 year was 8.8%. The preoperative back/leg visual analogue scale scores and functional outcome scales including EuroQol-5 dimension questionnaire, Oswestry Disability Index presented significant improvement immediately after surgery and were maintained until final follow-up.Conclusion: ULBRD for bilateral lateral recess stenoses without significant central stenosis resulted in good clinical outcomes with acceptably low perioperative complications rates. Sufficient decompression was achieved with the central ligamentum flavum being preserved.

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“…However, there is no consensus about how many days are needed following the ABS application. The follow-up days are ranged from 7 to 42 days in the reported literature [1,24]. Orhan et al used a 2-week follow-up similar to the present study [25].…”

Section: Ratsmentioning

confidence: 95%

Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery

Turkoz¹,

Demirel²,

H³

et al. 2020

Turk J Med Sci

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Introduction Haemostasis is described as the physiological systems which are necessary for stemming the bleeding and ensuring vascular integrity without blocking the blood flow. In terms of surgical procedures, adequate haemostasis provides many advantages in the postoperative period. Mechanical methods, bipolar cautery, oxidized cellulose, collagen, and gelatine are commonly employed for bleeding control. However, each of these methods has its risks and advantages. Ankaferd Blood Stopper (ABS) is a relatively new and effective method for bleeding control. ABS is used in traditional Turkish medicine and is prepared by mixing 5 herbal ingredients (Glycyrrhiza glabra, Vitis vinifera, Alpina officinarum, Urtica dioica, Thymus vulgaris) in different proportions. ABS affects blood proteins (mainly fibrinogen) and erythrocytes, and acts rapidly by forming a protein network. ABS is a preferably haemostatic agent which is easy to apply and does not damage healthy tissue. The topical haemostatic efficacy of ABS has been previously tested in animals with normal and defective haemostasis [1,2]. Physiological cell-based coagulation could be clinically managed via topical ABS applications to prevent and treat bleeding in many distinct clinicopathological states [3,4]. Neither local nor systemic adverse effects and/or toxicity have been observed in association with experimental and anecdotal topical application of ABS. The neurotoxic effects of ABS on neural tissue are yet to be investigated. Therefore, the neurotoxic effect of ABS was studied histopathologically in the present animal study. 2. Materials and methods 2.1. Experimental animals Prior to the study, ethical approval was obtained from Animal Studies Local Ethics Committee of Ondokuz Mayıs University with number 2008-37. Sprague Dawley male rats (16-20 weeks and 300-400 g) were used. A total of 30 rats were randomized into 2 groups as the ABS group (n: 15) and the control group (n: 15). Each group Background/aim: The aim of this study was to investigate the possible toxicity of the Ankaferd Blood Stopper (ABS) on the neural system. Materials and methods: Thirty Sprague Dawley rats were randomized into ABS (n: 15) and control (n: 15) groups. Following the anaesthetic induction, total laminectomy was performed to the lower thoracic, and upper lumbar areas in both groups and medulla spinalis was exposed. Two myelotomies were performed on the medulla spinalis. One millilitre ABS was applied to the incision site in the ABS group, and one millilitre 0.9% saline solution was applied in the control group. Rats were observed for 15 days regarding general behaviour, neurological signs, mobility, and signs of infection. Sixteen days later, all rats were decapitated under anaesthesia. Medulla spinalis was removed en bloc from all rats and was stained with Heamatoxylin & Eosin and luxol fast blue. Results: There was no significant difference between the ABS group and the control group regarding oedema, gliosis, the intensity of inflammatory cells, the presence of neuronal degener...

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The effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model

Abstract: The ankaferd blood stopper and microporous polysaccharide hemospheres reduced epidural fibrosis and arachnoideal involvement after laminectomy in rats.

Cited by 6 publications

References 29 publications

Comparison of the effect of bipolar coagulation and fibrillar structured oxidized cellulose on formation epidural fibrosis in rats

Comparison of the effect of bipolar coagulation and fibrillar structured oxidized cellulose on formation epidural fibrosis in rats

Full Endoscopic Ligamentum Flavum Sparing Unilateral Laminotomy for Bilateral Recess Decompression: Surgical Technique and Clinical Results

Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery

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