The effects of anthocyanins on body weight and expression of adipocyte’s hormones: Leptin and adiponectin

Tucakovic, Lada; Colson, Natalie Jane; Santhakumar, Abishek B.; Kundur, Avinash Reddy; Shuttleworth, Megan; Singh, Indu

doi:10.1016/j.jff.2018.03.042

Cited by 28 publications

(28 citation statements)

References 51 publications

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“…Twenty healthy volunteers supplemented for 4 weeks with 200 mL/day of ACN-rich Queen Garnet plum juice for 4 weeks had a significantly reduced body weight and BMI with an average decrease of 0.6 kg in body weight and 0.2 units in BMI. Furthermore, consumption of ACN-rich plum juice significantly increased adiponectin blood levels (average increase of 3.8 µg/mL) and decreased leptin blood levels (average decrease of 1.3 ng/mL) [ 46 ]. A study conducted by Vugic et al (2020) showed that the regular intake of ACNs reduced obesity-associated inflammation in obese subjects.…”

Section: Resultsmentioning

confidence: 99%

ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction

et al. 2021

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Oxidative stress and dysregulated adipocytokine secretion accompanying hypertrophied adipose tissue induce chronic inflammation, which leads to vascular endothelial dysfunction. The present study investigated the ability of anthocyanin (ACN) and non-anthocyanin polyphenol (PP) fractions from lingonberry fruit to mitigate adipose tissue hypertrophy and endothelial dysfunction using 3T3-L1 adipocytes and human umbilical vein endothelial cells (HUVECs). This study showed that the PP fraction decreased intracellular ROS generation in hypertrophied adipocytes by enhancing antioxidant enzyme expression (SOD2) and inhibiting oxidant enzyme expression (NOX4, iNOS). Moreover, PP and ACN fractions reduced triglyceride content in adipocytes accompanied by downregulation of the expression of lipogenic genes such as aP2, FAS, and DAGT1. Treatment with both fractions modulated the mRNA expression and protein secretion of key adipokines in hypertrophied adipocytes. Expression and secretion of leptin and adiponectin were, respectively, down- and upregulated. Furthermore, PP and ACN fractions alleviated the inflammatory response in TNF-α-induced HUVECs by inhibiting the expression of pro-inflammatory genes (IL-6, IL-1β) and adhesion molecules (VCAM-1, ICAM-1, SELE). The obtained results suggest that consuming polyphenol-rich lingonberry fruit may help prevent and treat obesity and endothelial dysfunction due to their antioxidant and anti-inflammatory actions.

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Section: Resultsmentioning

confidence: 99%

ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction

et al. 2021

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“…It may be presumed that other polyphenols also increase the expression of adiponectin, but the data are too scarce to confirm correlations between such substances as anthocyanins, lignans, resveratrol or quercetin and the concentration of adiponectin [ 82 , 83 , 84 , 85 , 86 , 87 , 88 ]. A study by Tucakovic et al [ 82 ] revealed that a four-week diet enhanced with the Queen Garnet plum, which is rich in anthocyanins, increased adiponectin concentrations by an average of 3.83 μg/mL ( p = 0.048). Yang et al [ 83 ] also demonstrated a correlation between anthocyanin supplementation for 12 weeks and adiponectin concentrations compared to placebo.…”

Section: Diet-related Factors With a Positive Influence On Adiponectin Concentrationsmentioning

confidence: 99%

The Influence of Nutrition on Adiponectin—A Narrative Review

2021

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The adipose tissue is an active endocrine organ which synthesizes and secretes a variety of adipokines, including adiponectin with its anti-inflammatory properties. Its expression is influenced by numerous factors such as age, sex, body weight and adipose tissue content. However, dietary factors, i.e., diet structure and the percentage of individual nutrients and products, are very important modulators. Beneficial dietary habits are the Mediterranean diet, DASH diet, diet based on plant products and diet with reduced energy value. Moreover, the share of individual products and nutrients which increase the concentration of adiponectin is worth noting. This group may include monounsaturated fatty acids, polyunsaturated omega-3 fatty acids, dietary fiber, polyphenols, alcohol and milk products. Conversely, dietary ingredients which have a negative effect on the concentration of adiponectin are typical components of the Western diet: saturated fatty acids, trans fatty acids, monosaccharides and disaccharides, and red meat. Furthermore, a diet characterized by a high glycemic index such as a high-carbohydrate low-fat diet also seems to be unfavorable. Due to the fact that available knowledge should be systematized, this study aimed to summarize the most recent research on the influence of dietary factors on the concentration of adiponectin.

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“…They possess anticancer (Liang et al 2019) anti-tumoral (Reboredo-Rodríguez 2018), anti-atherosclerotic (Long et al, 2018), anti-inflammatory (Perez-Meseguer et al 2019), anti-microbial (Bukhari et al 2019) and anti-obesity effects on human health and are the chemical componds that prevent neuronal and cardiovascular diseases (Yang et al, 2019, Watson et al, 2019, Zhang et al, 2019b. Anthocyanins have anti-obesity effects of blood lowering leptin levels by means of the modulation of adipocytokine secretion and lipid metabolism in the adipose tissue (Tucakovic et al, 2018). Obesity and overweight are described as excessive fat accumulation or abnormal that causes significant health risks by the WHO (World Health Organization, 2018).…”

Section: Introductionmentioning

confidence: 99%

Obesity-associated Pathways of Anthocyanins

et al. 2021

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Anthocyanins have a great potential for human health, as a subgroup of phenolic compounds. Interactions of anthocyanin involved in digestion and thus in obesity consist of inhibition of pancreatic lipase, regulation of lipolysis and lipogenesis, activation of an activated protein kinase enzyme, controlling of digestion hormones (leptin, insulin, ghrelin, cholecystokinin, GIP, GLP-1). Anthocyanins are the compounds that can control metabolic syndrome and obesity by ameliorating lipid metabolism, increasing energy expenditure, suppressing food intake and inhibiting lipid absorption. In addition, the interactions with other compounds during the processing and/or in the intestinal canal can change their absorption capability and bioavailability. Activation of mitogen-activated protein kinase and cyclooxygenase (COX) enzymes, inflammatory cytokines signaling, free-radical scavenging activity are among the primary functions of anthocyanins playing role in the basic metabolic pathways. Anthocyanins also interact with gut microbiota that plays a role in many metabolic pathways. In the review, the effects of anthocyanins on the obesity-associated mechanisms in the metabolism are considered and summarized under the light of recent researches.

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The effects of anthocyanins on body weight and expression of adipocyte’s hormones: Leptin and adiponectin

Cited by 28 publications

References 51 publications

ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction

ROS Modulating Effects of Lingonberry (Vaccinium vitis-idaea L.) Polyphenols on Obese Adipocyte Hypertrophy and Vascular Endothelial Dysfunction

The Influence of Nutrition on Adiponectin—A Narrative Review

Obesity-associated Pathways of Anthocyanins

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