The effects of anti-inflammatory cytokines on prostaglandin and cytokine production by human placental trophoblast cells

Goodwin, V; Mitchell, Michael J.; Keelan, Jeffrey

doi:10.1016/s1071-5576(97)86406-4

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“…Goodwin et al (9) reported that IL-4 transcriptionally suppresses the expression of COX-2 in human placental trophoblast cells. In addition, recent reports have shown that IL-10 and IL-13 inhibit the biosynthesis of PGE 2 in human amnion, chorion, and decidual cells by a mechanism whereby the production of COX-2 may be suppressed (7,18).…”

Section: Discussionmentioning

confidence: 99%

Hormonal regulation of PGE₂and COX-2 production in rabbit uterine cervical fibroblasts

Sato

Michizu

Hashizume

et al. 2001

Journal of Applied Physiology

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Prostaglandins (PGs) cause uterine contraction to initiate labor at term. We investigated the effect of progesterone and 17beta-estradiol on the production of PGE2 in rabbit uterine cervical fibroblasts. When the cervical fibroblasts were treated with interleukin-1alpha (IL-1alpha), the level of PGE2 was augmented in a time- and dose-dependent manner. The IL-1alpha-augmented PGE2 level was almost completely suppressed by progesterone and 17beta-estradiol at the physiological concentration (0.01 microM), whereas a slight decrease in the basal level of PGE2 was observed in the cervical fibroblasts treated with both hormones at a pharmacological concentration (1 microM). In addition, the level of PGE2 augmented by IL-1alpha was due to the increase of cyclooxygenase (COX) activity, which was inhibited by progesterone and 17beta-estradiol as well as by indomethacin and a specific COX-2 inhibitor, NS-398, but not by the well-known COX-1 inhibitor, aspirin. Furthermore, progesterone and 17beta-estradiol suppressed the IL-1alpha-augmented COX-2 production but not the constitutive production of COX-1 in rabbit uterine cervical fibroblasts. These results suggest that progesterone and 17beta-estradiol prevent the initiation of labor by inhibiting PGE2 production after the suppression of COX-2 production during pregnancy in the rabbit.

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Section: Discussionmentioning

confidence: 99%

Hormonal regulation of PGE₂and COX-2 production in rabbit uterine cervical fibroblasts

Sato

Michizu

Hashizume

et al. 2001

Journal of Applied Physiology

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show abstract

The effects of anti-inflammatory cytokines on prostaglandin and cytokine production by human placental trophoblast cells

Cited by 1 publication

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Hormonal regulation of PGE₂and COX-2 production in rabbit uterine cervical fibroblasts

Hormonal regulation of PGE₂and COX-2 production in rabbit uterine cervical fibroblasts

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The effects of anti-inflammatory cytokines on prostaglandin and cytokine production by human placental trophoblast cells

Cited by 1 publication

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Hormonal regulation of PGE2and COX-2 production in rabbit uterine cervical fibroblasts

Hormonal regulation of PGE2and COX-2 production in rabbit uterine cervical fibroblasts

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Hormonal regulation of PGE₂and COX-2 production in rabbit uterine cervical fibroblasts

Hormonal regulation of PGE₂and COX-2 production in rabbit uterine cervical fibroblasts