The Effects of Antipsychotics on Prolactin Levels and Women’s Menstruation

Abstract

Introduction. Typical and atypical antipsychotic agent is currently used for treatment in the majority of patients with psychotic disorders. The aim of this review is to assess antipsychotic induced hyperprolactinaemia and the following menstrual dysfunction that affects fertility, quality of life, and therapeutic compliance of women. Method. For this purpose, Medline, PsychInfo, Cochrane library, and Scopus databases were accessed, with a focus on the publication dates between 1954 and 2012. Research of references was also performed and 78 studies were retrieved and used for the needs of this review. Results. A summary of several antipsychotics as well as frequency rates and data on hyperprolactinaemia and menstrual disorders for different agent is presented. Conclusion. Diverse prevalence rates of hyperprolactinaemia and menstrual abnormalities have been found about each medication among different studies. Menstruation plays an important role for women, thus, understanding, careful assessment, and management of hyperprolactinaemia could enhance their lives, especially when dealing with women that suffer from a psychotic disorder.

Estrogen and schizophrenia in women: animal models lend a hand in understanding cognition

“…However, there is no difference between women suffering from schizophrenia and healthy women in successfully reproducing over all ages. The lower rates may also be influenced by other variables not readily considered such as lower rates of sexual activity, difficulties maintaining stable romantic relationships [27], medication induced abnormalities in prolactin levels and menstruation (which can vary depending on which medication is taken) [28] and medication induced sexual dysfunction (30-80% in women) [29][30][31]. It has been shown that more than half of the women with psychosis in the sample for the McGarth group (1999) were mothers and had higher levels of fertility was associated with a later age at first diagnosis [32].…”

Antipsychotic Induced Hyperprolactinemia in Schizophrenia Patients

“…1985). Prolaktin üzerine etkileri az olan olanzapin ve klozapin kullanımının tardiv diskineziye az oranda neden olduğu ve hatta tedavide kullanılabileceği belirtilmektedir (Bargiota 2013).…”

Evaluation of Hyperprolactinemia and Thyroid disorder among Patient with Abnormal Uterine bleeding

“…High Serum prolactin level can disturb the follicular maturation with corpus luteum function, and leads to inhibition of normal pulsatile secretion of gonadotrophins-releasing hormone in hypothalamus [8] . It also leads to deficient secretion of LH and FSH which leads to inadequate induction of proper ovarian response [9] .…”