The effects of arginine, dextran and Haemaccel infusions on urinary albumin, β2-microglobulin and

Renal impact of fluid management with colloids: a comparative review

“…In male volunteers receiving gelatin, increases were demonstrated in urinary excretion of albumin (P Ͻ 0.05), ␤ 2 -microglobulin (␤ 2 -MG; P Ͻ 0.01) and NAG (P Ͻ 0.05) [37]. Also, in healthy volunteers, gelatin administration resulted in ␣ 1 -microglobulinuria (P Ͻ 0.01) and ␤ 2 -microglobulinuria (P Ͻ 0.01) [67] and produced a dose-dependent increase in excretion of ␤ 2 -MG [52].…”

“…A total of 92 studies were included in the review: 23 randomized clinical trials [6,11,12,15,17,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]; 17 non-randomized controlled clinical studies [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]; 16 non-controlled cohort clinical studies [54][55][56][57][58][59][60][61][62][63][64]…”

Arginine infusion blocks the action of parathyroid hormone but not arginine vasopressin on the renal tubule in man

“…This is supported by the finding that the phosphaturia, and increase in urinary cAMP excretion in response to PTH, was decreased when PTH was given during an arginine infusion. Further support is given by our observation (O'Reilly et al 1986) that the receptor-mediated uptake of proteins by the renal tubule is transiently blocked over the same period of time after an arginine infusion.…”

“…We have shown that this arginineinduced tubular proteinuria is accompanied by an increase in the urinary excretion of the lysosomal enzyme N-acetyl-ß-D-glucosaminidase (EC 3.2.1.52;NAG) (O'Reilly, Parry & Whicher, 1986). These effects suggest that arginine is nephrotoxic and would therefore be associated with phosphaturia and hyposthenuria.…”

“…However, we have concluded that arginine infusions are not nephrotoxic as the tubular proteinuria and increase in urinary NAG excretion are transient, lasting less than 180 min, and are not accompanied by glycosuria or aminoaciduria. The infusions cause a diuresis but there is a transient decrease in phosphate excretion (O'Reilly, Parry & Whicher, 1986). This effect of intravenous arginine infusions on urinary phosphate excretions may be of some importance in the pathogenesis of the bone disease observed in patients on long-term total parenteral nutrition (De Vernejoul, Messing, Modrowski et al 1985).…”