The Effects of Ascorbic Acid in Relation to Lead Absorption

Evans, E.

doi:10.1001/jama.1943.02840070029009

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…Back in 1940 Dannenberg et al described an unsuccessful attempt to treat with ascorbic acid a 27-month-old child suffering from lead encephalopathy. Studies in lead-exposed workers did not show beneficial effect of ascorbic acid on blood lead concentration, lead elimination and/or biochemical markers of lead toxicity (Evans et al 1943;Lauwerys et al 1983). Dietary ascorbic acid supplementation also did Author for correspondence: Veda M. Varnai, Institute for Medical Research and Occupational Health, P.O.…”

mentioning

confidence: 99%

Ascorbic Acid Supplementation Does Not Improve Efficacy of meso‐Dimercaptosuccinic Acid Treatment in Lead‐Exposed Suckling Rats

Varnai

Piasek

Blanuša

et al. 2003

Pharmacology & Toxicology

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It was suggested that ascorbic acid as a natural chelating agent can influence lead toxicokinetics and improve chelating properties of dimercaptosuccinic acid (DMSA) in adult rats. In this paper potential benefits of ascorbic acid supplementation, alone or combined with DMSA, in decreasing lead retention in suckling rats were evaluated. Such data in young mammals are not available. L-Ascorbic acid (daily dose 650 mg/kg b.wt.) and/or DMSA (daily dose 91 mg/kg b.wt.) were administered orally to suckling Wistar rats either during ongoing 8-day oral lead exposure (as acetate; daily dose 2 mg lead/kg b.wt.) or after 3-day lead exposure (total dose 12 mg lead/kg b.wt.). Lead concentrations were analysed in the carcass (skeleton), liver, kidneys and brain by atomic absorption spectrometry. By ascorbic acid supplementation lead retention was not reduced under either lead exposure condition. Lead concentration was even increased in the carcass. Treatment with DMSA under both exposure conditions significantly reduced lead in all analysed tissues. Combined treatment with ascorbic acid and DMSA during ongoing lead exposure was substantially less effective than DMSA treatment alone, and did not affect DMSA efficacy when administered after lead exposure. It was concluded that ascorbic acid administered either during or after lead exposure in suckling rats has no beneficial effect on either lead retention or DMSA chelation effectiveness.

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confidence: 99%

Ascorbic Acid Supplementation Does Not Improve Efficacy of meso‐Dimercaptosuccinic Acid Treatment in Lead‐Exposed Suckling Rats

Varnai

Piasek

Blanuša

et al. 2003

Pharmacology & Toxicology

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“…HoImes et al (1939 provided evidence for reduced severity of lead toxicity in metal workers after ascorbic acid therapy. but this was not the case for workers in a tetraethyl lead plant (Evans et al 1943). These contradictory findings may be a result of an improvement in overall health of lead-poisoned patients, previously having a poor diet, as we11 as a lead-chelating action of ascorbic acid similar to that of EDTA (ethylenzdiaminetetraacetic acid) (Goycr and Chcrian 1978).…”

Section: Resultsmentioning

confidence: 98%

Effects of Dietary Ascorbic Acid on Chronic Lead Toxicity to Young Rainbow Trout (Salmo gairdneri)

Hodson¹,

Hilton²,

Blunt³

et al. 1980

Can. J. Fish. Aquat. Sci.

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Effects of dietaryascorbic acid oaa chronic lead toxicity to young rainbow trout (SaBmo gatriineri). Can. 1. Fish. Aquat, Newly hatched rainbow trout (Salmo gairdneri) exposed to waterborne lead and receiving diets deficient in. or supplemented with, ascorbic acid, developed classical symptoms of iead toxicity and ascorbic acid deficiency. Those exposed to lead showed elevated blood lead concentrations, inhibition of erythrocyte &amino levulinic acid dehydratase, darkening of the tail regions and spinal curvatures. Those receiving ascorbate deficient diets showed depletion of carcass, liver, kidney, and brain ascorbic acid concentrations plus spinal curvatures. Fish subjected to both treatments simultaneously showed no evidence of an enhancement of aacorbate deficiency symptoms by exposure to lead or enhancement or reduction of lead toxicity symptoms by ascorbate deficient or supplemented diets, respectively. These results demonstrate that, although aspects of lead toxicity in fish resemble ascorbic acid deficiency, there is no metabolic interaction between the two factors. . 1980. Effects of dietary ascorbic acid on chronic lead toxicity to young rainbow trout (Salmo gairdvleri). Can. J. Fish. Aquat. Sci. 37: 17@%76. Bes truites arcen-ciel (Salmo gairdneri) nouvellement ecloses exposks A du plomb contenu dans I'eau et recevant des regimes dkficients en acide ascorbique ou avec supplkment cle cet acide dkveloppe~st les syrnptcmes slassiques de toxicitk par B e plornb et de deficience d'acide ascorbique. Ees truites exposees au plomb msntrent une plus forte concentration de plomb sanguin, inhibition de la 6-amia101evuIinique acide ddshydratase des Crythroeytes, assombrissement de la rdgion caudale et courbatures de I'epine dorsale. Les truites nourries A des regimes pauvres en ascsrbates montreiat un Cpuisement des concentrations d'acide ascorbique dans le squelette, fuie, rein et cerveau, en plus de courbatures de 1'Cpine dorsale. Les poissons soumis simultandment aux deux traitements ne rnontrent pas de signe d'aggravation des sympt6mes de dCficience d'ascorbates causCe par exposition au plomb, ou augmentation ou reduction des symptames de toxicit6 par le plomb causee par des rigimes dam lesquels les ascorbates sont deficients ou ont Cte ajoutks respectivement. Ces resultats demontrent que, bien que les aspects de la toxicite par le pBomb chez les poissons ressemblent 2i une deficience d'acide ascorbique, il n'y a pas d'interastion rn6tabolique entre les deux facteurs.

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“…Pillemer and coworkers (30) found that lead poisoned guinea pigs on a scorbutic diet developed neurological symptoms more readily than did lead poisoned animals fed ascorbic acid adequate diets. Other investigators, however, have found ascorbic acid to be without effect in lead toxicity (31,32).…”

Section: Toxic Effects Of Leadmentioning

confidence: 88%

Susceptibility to Lead Toxicity

Goyer¹,

Mahaffey²

1972

Environmental Health Perspectives

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The Effects of Ascorbic Acid in Relation to Lead Absorption

Abstract: reported a case, with similar symptoms to ours, responding favorably to orchiectomy: A man aged 71 had abdominal and low back pain, numbness over the buttocks and posterior part of the thighs as well as urinary and fecal inconti¬ nence.

Cited by 11 publications

References 3 publications

Ascorbic Acid Supplementation Does Not Improve Efficacy of meso‐Dimercaptosuccinic Acid Treatment in Lead‐Exposed Suckling Rats

Ascorbic Acid Supplementation Does Not Improve Efficacy of meso‐Dimercaptosuccinic Acid Treatment in Lead‐Exposed Suckling Rats

Effects of Dietary Ascorbic Acid on Chronic Lead Toxicity to Young Rainbow Trout (Salmo gairdneri)

Susceptibility to Lead Toxicity

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