The effects of ATP on the contractions of rat and mouse fast skeletal muscle

Зиганшин, А. У.; Khairullin, A. E.; Teplov, A. Yu.; Gabdrakhmanov, Azat I.; Зиганшина, Л. Е.; Hoyle, Charles H.V.; Ziganshin, Bulat A.; Гришин, С. Н.

doi:10.1002/mus.26423

Cited by 16 publications

(17 citation statements)

References 40 publications

(73 reference statements)

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“…ATP is also inhibitory [71], but its effect is half of that, observed in the soleus slow muscle (Figure 2). As for the rat diaphragm, which is a muscle of mixed composition, we observed the opposite, presynaptic potentiating effect of ATP [74], while others [44,45,77,78] reported the inhibitory action of this purine (Table 1).…”

Section: Int J Mol Sci 2020 21 X For Peer Review 6 Of 15mentioning

confidence: 78%

“…The inhibitory presynaptic effect of ATP, similar to that previously found in frogs [14,21,44,64,69], has been also shown for the rat slow soleus muscle [76] (see Figure 2). Interestingly, that in the fast extensor digitorum longus (EDL) muscle (rat) the presynaptic modulatory action of ATP is also inhibitory [71], but its effect is half of that, observed in the soleus slow muscle (Figure 2). As for the rat diaphragm, which is a muscle of mixed composition, we observed the opposite, presynaptic potentiating effect of ATP [74], while others [44,45,77,78] reported the inhibitory action of this purine (Table 1).…”

Section: Effects Of Atp and Adenosine On Induced Quantal Secretionmentioning

confidence: 96%

“…In recent years, there has been an expansion in the field of studies of the modulating effects of purines in neuromuscular junctions [64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79]. Along with studies on the refinement of the subtype of the presynaptic P2 receptor involved in modulation in "classical" preparations [64,65,69,70,[73][74][75]77,78], studies are being conducted to cover a broader spectrum of types of motor units in different laboratory animals [67,68,71,72,76,79] (see Table 1). Notes: The arrows indicate the direction of the effect: ↑-facilitation; ↓-inhibition.…”

Section: Effects Of Atp and Adenosine On Induced Quantal Secretionmentioning

confidence: 99%

“…As for the rat diaphragm, which is a muscle of mixed composition, we observed the opposite, presynaptic potentiating effect of ATP [74], while others [44,45,77,78] reported the inhibitory action of this purine (Table 1). In contrast, in mouse fast and slow muscle preparations the presynaptic action of ATP is potentiation [71,72], while in mouse diaphragm it is reported to be either potentiation [74] or inhibition [25,65,75] (Table 1).…”

Section: Int J Mol Sci 2020 21 X For Peer Review 6 Of 15mentioning

confidence: 99%

“…Interestingly, in the presence of adenosine (which has a similar effect to cholinomimetics on quantal secretion), carbachol did not display its own inhibitory effect on the quantal secretion of ACh [81]. In contrast, in mouse fast and slow muscle preparations the presynaptic action of ATP is potentiation [71,72], while in mouse diaphragm it is reported to be either potentiation [74] or inhibition [25,65,75] (Table 1).…”

Section: Effects Of Atp and Adenosine On Spontaneous Quantal Secretionmentioning

confidence: 99%

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Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Зиганшин

Khairullin

Hoyle

et al. 2020

IJMS

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A review of the data on the modulatory action of adenosine 5’-triphosphate (ATP), the main co-transmitter with acetylcholine, and adenosine, the final ATP metabolite in the synaptic cleft, on neuromuscular transmission is presented. The effects of these endogenous modulators on pre- and post-synaptic processes are discussed. The contribution of purines to the processes of quantal and non-quantal secretion of acetylcholine into the synaptic cleft, as well as the influence of the postsynaptic effects of ATP and adenosine on the functioning of cholinergic receptors, are evaluated. As usual, the P2-receptor-mediated influence is minimal under physiological conditions, but it becomes very important in some pathophysiological situations such as hypothermia, stress, or ischemia. There are some data demonstrating the same in neuromuscular transmission. It is suggested that the role of endogenous purines is primarily to provide a safety factor for the efficiency of cholinergic neuromuscular transmission.

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Section: Int J Mol Sci 2020 21 X For Peer Review 6 Of 15mentioning

confidence: 78%

Section: Effects Of Atp and Adenosine On Induced Quantal Secretionmentioning

confidence: 96%

Section: Effects Of Atp and Adenosine On Induced Quantal Secretionmentioning

confidence: 99%

Section: Int J Mol Sci 2020 21 X For Peer Review 6 Of 15mentioning

confidence: 99%

Section: Effects Of Atp and Adenosine On Spontaneous Quantal Secretionmentioning

confidence: 99%

See 3 more Smart Citations

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Зиганшин

Khairullin

Hoyle

et al. 2020

IJMS

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Effects of low‐dose metformin on pre‐frailty among middle‐aged and elderly pre‐diabetic people

Huang

Shiao

Mao

2022

JCSM Rapid Communications

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Background Pre-frailty has been identified as a clinically silent mechanism pre-disposing people to frailty. The goal of this study is to investigate the impact of low-dose metformin on pre-diabetic pre-frail patients (>50 years) on skeletal muscle mass, speed of gait, handgrip power, and health-related quality of life (HR-QoL). Methods We did a retrospective cohort study of subjects aged 50 years and older who were diagnosed with pre-frailty (one or two criteria present based on Fried Frailty Index) and pre-diabetes (HbA1c 5.7% to 6.4%) from May 2018 to April 2020. Subjects taking low-dose metformin were compared with non-metformin participants through a review of the medical records. The results were analysed at baseline and 6-12 months post-prescription with or without metformin. All data were accompanied by a 95% confidence interval. Results One hundred and thirteen pre-diabetic and pre-frail subjects were recruited to metformin [the mean metformin administration was 750 (140) mg/day] (n = 58) or control group (n = 55). The average age was 66.3 (6.8) years old, with 52.2% of the population being female. The baseline demographic, nutritional, physical, and mental status data did not differ between groups. In comparison with the control group, an 8.9 (1.8) month low-dose metformin intervention resulted in a higher skeletal muscle mass index of 1.26 (1.66) kg/m 2 (P = 0.029), a faster gait speed of 0.15 (0.22) m/s (P = 0.011), and a greater handgrip strength of 2.1 (2.9) kg (P = 0.037). However, there was no difference in myostatin serum levels or HR-QoL between groups. Conclusions Low-dose metformin was statistically and clinically meaningful to improve the original skeletal muscle mass index, gait speed, and grip strength as part of the sarcopenia dimension, but the Euro Quality of Life-5 Dimensions index and myostatin serum levels did not change significantly.

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Purinergic Tuning of the Tripartite Neuromuscular Synapse

2023

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The vertebrate neuromuscular junction (NMJ) is a specialised chemical synapse involved in the transmission of bioelectric signals between a motor neuron and a skeletal muscle fiber, leading to muscle contraction. Typically, the NMJ is a tripartite synapse comprising (a) a presynaptic region represented by the motor nerve ending, (b) a postsynaptic skeletal motor endplate area, and (c) perisynaptic Schwann cells (PSCs) that shield the motor nerve terminal. Increasing evidence points towards the role of PSCs in the maintenance and control of neuromuscular integrity, transmission, and plasticity. Acetylcholine (ACh) is the main neurotransmitter at the vertebrate skeletal NMJ, and its role is fine-tuned by co-released purinergic neuromodulators, like adenosine 5′-triphosphate (ATP) and its metabolite adenosine (ADO). Adenine nucleotides modulate transmitter release and expression of postsynaptic ACh receptors at motor synapses via the activation of P2Y and P2X receptors. Endogenously generated ADO modulates ACh release by acting via co-localised inhibitory A1 and facilitatory A2A receptors on motor nerve terminals, whose tonic activation depends on the neuronal firing pattern and their interplay with cholinergic receptors and neuropeptides. Thus, the concerted action of adenine nucleotides, ADO, and ACh/neuropeptide co-transmitters is paramount to adapting the neuromuscular transmission to the working load under pathological conditions, like Myasthenia gravis. Unravelling these functional complexities prompted us to review our knowledge about the way purines orchestrate neuromuscular transmission and plasticity in light of the tripartite synapse concept, emphasising the often-forgotten role of PSCs in this context.

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The effects of ATP on the contractions of rat and mouse fast skeletal muscle

Cited by 16 publications

References 40 publications

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Modulatory Roles of ATP and Adenosine in Cholinergic Neuromuscular Transmission

Effects of low‐dose metformin on pre‐frailty among middle‐aged and elderly pre‐diabetic people

Purinergic Tuning of the Tripartite Neuromuscular Synapse

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