The Effects of Autologous Platelet-Rich Fibrin on Flexor Tendon Healing in a Rabbit Model

Liao, Janice C.Y.; He, Min; Gan, Aaron W.T.; Chong, Alphonsus K.S.

doi:10.1016/j.jhsa.2017.06.098

Cited by 7 publications

(18 citation statements)

References 13 publications

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“…In perusing the literature, the potential effectiveness of PRF in vitro [101,102,103] or the outcomes of its pre-clinical or clinical use, have been investigated. Rotator cuff tears [104,105,106,107,108,109,110,111,112], ruptures of the Achilles tendon [101,113,114], flexor tendon healing [115,116], patellar tendon defects and medial collateral ligament reconstruction [117,118], as well as repair of gluteus medius tendons [119], are the preferred end-use destinations considered by the authors.…”

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

“…The literature reports on pre-clinical studies aiming to develop new approaches PRF-based towards, Achilles tendon rupture [101,114], regeneration of the tendon-bone insertion [108], healing of flexor tendon [115,116] and patellar tendon [117], also including medial collateral ligament reconstruction [118].…”

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

“…Different animal models of injuries were considered; the first experimental works were carried out on species with a complex neurological development, including sheep [101,114] and dogs [117]. Later, ethic issues, a growing awareness of the value of responsible animal research, together with mature surgical experience with the use of hemocomponents for regenerative purposes, have prompted researchers to favor species with simpler neurological developments, like rabbits [115,116,118] and rats [108].…”

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

“…The authors described the manufacture of different PRF-derived products according to the content in platelets and/or structure, but a shared preparation-protocol, as well as a strong characterization study to allow for comparisons, is lacking. Visser et al [117], Hasan et al [108], Liao et al [116] studied PRF; Anitua et al [101] considered both platelet-rich and platelet-poor matrices; others included plasma in the fibrin matrix (i.e., platelet-rich plasma fibrin matrix—PRPFM) [114,115] and then compared its healing effect versus PRP [115], while Matsunaga et al [118] described a novel protocol to prepare a Compact Platelet-Rich Fibrin Scaffold (CPFS) resembling a sheet. Concerning surgical practice, hemocomponents were used either alone as a booster of tissue healing after surgery [101,108,115,116,117,118], or combined to an acellular porcine dermal (APD) patch [114].…”

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

“…Interestingly, regarding the origin of hemocomponents, both autologous [101,114,116,117] and allogenic preparations [108,115,118] were investigated. Assessing the effectiveness of allogenic products verifies the efficacy of these therapeutic approaches, even in patients for whom there are no clinical indications for autologous preparations (e.g., thrombocytopenic patients).…”

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

See 4 more Smart Citations

Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Barbon

Stocco

Macchi

et al. 2019

IJMS

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Nowadays, research in Tissue Engineering and Regenerative Medicine is focusing on the identification of instructive scaffolds to address the requirements of both clinicians and patients to achieve prompt and adequate healing in case of injury. Among biomaterials, hemocomponents, and in particular Platelet-rich Fibrin matrices, have aroused widespread interest, acting as delivery platforms for growth factors, cytokines and immune/stem-like cells for immunomodulation; their autologous origin and ready availability are also noteworthy aspects, as safety- and cost-related factors and practical aspects make it possible to shorten surgical interventions. In fact, several authors have focused on the use of Platelet-rich Fibrin in cartilage and tendon tissue engineering, reporting an increasing number of in vitro, pre-clinical and clinical studies. This narrative review attempts to compare the relevant advances in the field, with particular reference being made to the regenerative role of platelet-derived growth factors, as well as the main pre-clinical and clinical research on Platelet-rich Fibrin in chondrogenesis and tenogenesis, thereby providing a basis for critical revision of the topic.

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Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

Section: Prf In Tendon Tissue Engineeringmentioning

confidence: 99%

See 3 more Smart Citations

Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Barbon

Stocco

Macchi

et al. 2019

IJMS

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show abstract

Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey

Abdelhakiem

Hussein

Seleim

et al. 2023

Sci Rep

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This study investigated the effect of the silver nanoparticles (AgNPs) and platelet-rich fibrin (PRF) in the healing of the severed superficial digital flexor tendon in donkeys (SDFT). Twenty-seven adult donkeys were used in the study. The animals were divided into three equal groups. The first group (control group) in which the severed SDFT was sutured without the addition of any adjuvant. In the second group, there was a suture of severed SDFT with the addition of 1 ml of 1 mM silver nanoparticles (AgNPs group). The third group was subjected to the cutting of SDFT and then the addition of PRF after its suture. Each group of animals was divided into three equal subgroups that were examined after 1, 2, and 3 months. Each group of animals was clinically evaluated by assessing lameness. Gross and microscopic examinations of the healed tendons were performed after 1, 2, and 3 months of surgery. In comparison to the control group, the lameness degree decreased in the PRF and AgNPs groups, particularly in the third month after surgery. Furthermore, the lameness decreased significantly after the 3rd month relative to the 1st-month lameness in the AgNPs group. Interestingly, it was found that the PRF and AgNPs enhanced cell alignment and collagen deposition at the site of tendon injury, particularly among third-month subgroups. Therefore, it could be concluded that the PRF and AgNPs are effective materials for enhancing SDFT healing in donkeys.

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Effect of Platelet-Rich Fibrin on Biomechanical and Biochemical Aspects of Tendon Healing: A Preliminary Animal Study

Yousefi

Kazemi

Rezaei

2022

J. Musculoskelet. Res.

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Purpose: To investigate the effect of platelet-rich fibrin as a rich source of growth factors on biomechanical and biochemical aspects of tendon healing. Methods: Tendon defects were created in six adult male mixed breed dogs by surgical resection of the central third of the patellar tendon of both hind limbs. The defects were either treated by platelet-rich fibrin implantation or left empty. The animals were euthanized one, three and six months after surgery and their patellar tendons harvested for determination of ultimate stress, ultimate strain, tensile strength and Young’s modulus of elasticity along with hydroxyproline content. Results: Significant differences were not observed in mean values of the measured biomechanical and biochemical parameters at any time point between the two groups. Conclusions: Based on the results of the present study, PRF did not have a positive influence on biomechanical and biochemical aspects of tendon healing in dogs.

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The Effects of Autologous Platelet-Rich Fibrin on Flexor Tendon Healing in a Rabbit Model

Cited by 7 publications

References 13 publications

Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Platelet-Rich Fibrin Scaffolds for Cartilage and Tendon Regenerative Medicine: From Bench to Bedside

Silver nanoparticles and platelet-rich fibrin accelerate tendon healing in donkey

Effect of Platelet-Rich Fibrin on Biomechanical and Biochemical Aspects of Tendon Healing: A Preliminary Animal Study

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