The effects of BaTiO3 on the handleability and mechanical strength of the prepared piezoelectric calcium phosphate silicate for bone tissue engineering

Wu, Tao; Ji, Xiujuan; Zhang, Zaishan; Wang, Shun; Zhou, Jingqiu; Meng, Lisha; Liu, Xinyu; Yu, Hailong; Gong, Tianxing; Liu, Yao

doi:10.1016/j.ceramint.2023.03.092

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…The deformation of BTO causes an asymmetric shift of dipoles in the crystal lattice and generates piezoelectricity. This makes BTO an attractive biomaterial for biomedical applications in the human body where bioelectricity plays an important role, such as in the neuronal system [ 4 ], cardiology [ 5 ], and bone regeneration [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Chang,

Chen,

Cheng

et al. 2024

Materials

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Barium titanate (BaTiO3, BTO), conventionally used for dielectric and ferroelectric applications, has been assessed for biomedical applications, such as its utilization as a radiopacifier in mineral trioxide aggregates (MTA) for endodontic treatment. In the present study, BTO powders were prepared using the sol-gel process, followed by calcination at 400–1100 °C. The X-ray diffraction technique was then used to examine the as-prepared powders to elucidate the effect of calcination on the phase composition and crystalline size of BTO. Calcined BTO powders were then used as radiopacifiers for MTA. MTA-like cements were investigated to determine the optimal calcination temperature based on the radiopacity and diametral tensile strength (DTS). The experimental results showed that the formation of BTO phase was observed after calcination at temperatures of 600 °C and above. The calcined powders were a mixture of BaTiO3 phase with residual BaCO3 and/or Ba2TiO4 phases. The performance of MTA-like cements with BTO addition increased with increasing calcination temperature up to 1000 °C. The radiopacity, however, decreased after 7 days of simulated oral environmental storage, whereas an increase in DTS was observed. Optimal MTA-like cement was obtained by adding 40 wt.% 1000 °C-calcined BTO powder, with its resulting radiopacity and DTS at 4.83 ± 0.61 mmAl and 2.86 ± 0.33 MPa, respectively. After 7 days, the radiopacity decreased slightly to 4.69 ± 0.51 mmAl, accompanied by an increase in DTS to 3.13 ± 0.70 MPa. The optimal cement was biocompatible and verified using MG 63 and L929 cell lines, which exhibited cell viability higher than 95%.

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Section: Introductionmentioning

confidence: 99%

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Chang,

Chen,

Cheng

et al. 2024

Materials

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“…Previous research has demonstrated CPSC's e cacy as a drug delivery platform and its signi cant role in promoting bone regeneration . Furthermore, its injectable form offers remarkable versatility and ease of application, adapting seamlessly to various bone defect geometries (Wu, et al, 2023, Gong, et al, 2022. This investigation aims to thoroughly assess the potential of curcumin-enriched CPSC (CPSC-Cur) as an advanced biomaterial for bone tissue engineering, especially in contexts complicated by bone cancer.…”

Section: Introductionmentioning

confidence: 99%

Cellulose Nanofiber Reinforced Curcumin-Infused Calcium Phosphate Silicate Cement: Material Characterization and Biocompatibility Assessment for Bone Cancer Defect Repair

Lu,

Meng,

Zhou

et al. 2024

Preprint

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This study introduces a pioneering approach in bone tissue engineering for addressing defects caused by bone cancer, utilizing a novel injectable curcumin (Cur)-infused calcium phosphate silicate cement (CPSC). The research focuses on evaluating the dual functionality of CPSC-Cur: promoting bone regeneration and exerting cytotoxic effects on osteosarcoma cells. The material's physicochemical properties, biocompatibility with osteoblasts, and cytotoxicity towards osteosarcoma cells were rigorously analyzed. The findings demonstrate that CPSC-Cur significantly prolongs the setting time, which can be optimized by adding silanized cellulose nanofiber (CNF-SH) to achieve a balance between workability and mechanical strength. Biological assessments reveal a pronounced cytotoxic effect on osteosarcoma cells while maintaining minimal toxicity towards pre-osteoblasts, highlighting CPSC-Cur's potential as a promising material for repairing bone defects following cancer removal. This study lays the groundwork for future investigations into CPSC-Cur's in vivo efficacy and its role in the clinical treatment of bone cancer-related defects.

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Novel injectable calcium-magnesium phosphate cement-based composites with piezoelectric properties: advancements in bone regeneration applications

Sakar,

Ziylan Albayrak,

Karakaya

et al. 2024

J Mater Sci: Mater Electron

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Designing a novel injectable bone cement is an important approach to the success of bone healing in minimally invasive surgeries. As natural bone has a piezoelectric property, which is crucial in bone regeneration, this study focused on the development of a novel injectable composite bone cement with piezoelectric properties. For the composite composition, calcium and zirconium doped barium titanate (BCZT) was used for its piezoelectric property, while calcium phosphate and magnesium phosphate cement (CMPC) were preferred for its bone-like properties. In this framework, first BCZT, CMPC, and their composites were prepared, and their phase structures, particle size distributions, and piezoelectric and dielectric properties were investigated. Then, the composite bone cements were prepared by mixing CMPC with BCZT in three different ratios (20%, 30%, and 40%). Next, polysorbate 80 solution was added to the cement mixtures to prepare the injectable pastes. Finally, injectability, setting time, and compressive strength of the composites were assessed. As a result, the composite bone cement containing 30% BCZT has the potential to be used as an injectable bone cement in invasive orthopedic surgery.

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The effects of BaTiO3 on the handleability and mechanical strength of the prepared piezoelectric calcium phosphate silicate for bone tissue engineering

Cited by 7 publications

References 30 publications

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Effects of Calcination Temperature on the Synthesis of One-Pot Sol-Gelled Barium Titanate Powder and Its Performance as an Endodontic Radiopacifier

Cellulose Nanofiber Reinforced Curcumin-Infused Calcium Phosphate Silicate Cement: Material Characterization and Biocompatibility Assessment for Bone Cancer Defect Repair

Novel injectable calcium-magnesium phosphate cement-based composites with piezoelectric properties: advancements in bone regeneration applications

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