The Effects of Berberis integerrima Fruit Extract on Glycemic Control Parameters in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Clinical Trial

Abstract

Background. Berberis integerrima Bunge fruits have been utilized in traditional medicine to control diabetes mellitus (DM). However, no clinical survey has been done in this regard. This study was conducted to clinically evaluate the effects of fruit extract of this plant in improving glycemic control indices in patients with type 2 DM (T2DM). Methods. In a randomized controlled clinical trial, patients with T2DM who met the inclusion criteria were randomly divided into two groups of drug (Berberis) and control to receive the extract solution 5 ml twice daily (equivalent to 1000 mg of dry extract) with standard treatment (metformin) or only standard treatment, respectively, for 8 weeks. Before and after the intervention, fasting blood sugar (FBS), serum glycosylated hemoglobin (HbA1c), serum insulin, the homeostasis assessment model for insulin resistance (HOMA-IR), body mass index (BMI), and systolic and diastolic blood pressure were determined and compared between the two groups. Results. During the study, 30 and 35 patients in the drug and control groups, respectively, completed the study. Although no significant changes occurred in any parameter within each group, postintervention FBS (117.5 [107–128.8] versus 134 [120–142], P = 0.001 ) and HbA1c (7 [6.4–7.7] versus 7.5 [6.8–7.9], P = 0.045 ) were significantly lower in the drug group than in the control one. In terms of other parameters, there were no significant differences between the groups. Conclusion. Consumption of B. integerrima Bunge fruit extract at a dosage of 1000 mg daily decreases FBS and HbA1c but does not affect HOMA-IR in patients with type 2 diabetes mellitus.

Effect of Berberine Supplement in Iraqi Sample of Type 2 Diabetic Patients with Recurrent Urinary Tract Infections

“…Insulin sensitivity, activation of the AMPK pathway, induction of glucagon-like protein-1 secretion from the gut, stimulation of glycolytic processes in peripheral tissues, inhibition of gluconeogenesis, an increase in glucose transporters in cells, and a decrease in -glucosidase activity are just a few of the possible mechanisms underlying this effect. 17 The current investigation found that berberine had a significant effect on FPG serum levels, in accordance with the conclusions of this study of Homeira Rashidi, et al, 2018, 18 LadanTahmaseb, et al, 2019, 19 and Rasool Soltani, et al, 2021, discovered that patients with T2DM, had significant improvements than the control group, which is consistent with our findings. 20 Berberine has a protective impact on the kidneys, and that it is also through administration provided morphological and functional protection.…”

“…17 The current investigation found that berberine had a significant effect on FPG serum levels, in accordance with the conclusions of this study of Homeira Rashidi, et al, 2018, 18 LadanTahmaseb, et al, 2019, 19 and Rasool Soltani, et al, 2021, discovered that patients with T2DM, had significant improvements than the control group, which is consistent with our findings. 20 Berberine has a protective impact on the kidneys, and that it is also through administration provided morphological and functional protection. Apoptosis and oxidative stress were avoided in renal injury due to Ischemia-reperfusion (I/R) by administering berberine.…”

Effects and mechanisms of anti-diabetic dietary natural products: an updated review

“…For instance, a randomized clinical trial (RCT) showed that intervention using the fruits of Berberis integerrima for 8 weeks decreased FBG and HbA1c in 65 T2D patients. 97 Another intervention involving Berberis vulgaris fruit for 8 weeks also decreased FBG. 98 Additionally, based on an RCT, it was shown that Morinda citrifolia fruit juice decreased FBG, HbA1c, and high sensitivity C-reactive protein (hs-CRP), and increased C-peptide in 20 T2D patients undergoing standard treatment, indicating that it could ameliorate diabetes by promoting insulin excretion and alleviating inflammation.…”

Evaluation of the effectiveness of Berberis integerrima Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial

“…For the purpose of standardizing the barberry root extract, the polyphenol content was determined according to Folin-Ciocalteu's method as described before. 22 Briefly, 20 μL of the diluted solution were mixed with 100 μL of Folin-Ciocalteau reagent, 450 μL of water, and made up to 2 mL with saturated sodium carbonate solution. The solution was left for 2 h at room temperature and in a dark environment.…”