The Effects of Bifidobacterium Probiotic Supplementation on Blood Glucose: A Systematic Review and Meta-Analysis of Animal Models and Clinical Evidence

Effect of Probiotic Supplementation on Intestinal Permeability in Overweight and Obesity: A Systematic Review of Randomized Controlled Trials and Animal Studies

“…Furthermore, most clinical studies included in the review evaluated probiotic supplementation for <6 mo, thus making it difficult to draw any conclusions on the long-term effects of these interventions. Lastly, the use of multi-strain probiotic formulations limits our understanding of individual strain-specific effects of probiotics on intestinal barrier function in the context of overweight and obesity [ 116 ]. Future directions for this research should include comparisons of specific probiotic species on intestinal permeability in inflammatory diseases and additional studies to determine appropriate doses and treatment durations to reduce intestinal permeability in both sexes.…”

The Effect of Bifidobacterium animalis subsp. lactis MN-Gup on Glucose Metabolism, Gut Microbiota, and Their Metabolites in Type 2 Diabetic Mice

“…Compared to the control group, both low and high doses of MN-Gup significantly reduced the FBG levels (L-MG: MD = −3.13 mmol/L, CI [−4.87, −1.40] mmol/L; H-MG: MD = −3.83 mmol/L, CI [−5.56, −2.10] mmol/L, p < 0.001, Table S1 ). A meta-analysis of Bifidobacterium probiotics indicated MN-Gup’s superior hypoglycemic effect compared to other strains [ 28 ]. Additionally, MN-Gup exhibited efficacy comparable to metformin, a first-line therapy for T2DM [ 29 ], with reductions in the FBG levels (MF: MD = −5.02 mmol/L, CI [−6.75, −3.28] mmol/L, p < 0.001, Table S1 ).…”

The gut microbial composition in polycystic ovary syndrome with hyperandrogenemia and its association with steroid hormones

“…Six species, including Bifidobacterium , were significantly elevated in the HA-PCOS group. Bifidobacterium is known to play a beneficial role in maintaining gut health and overall wellbeing ( Van Syoc et al, 2023 ). The ecological role of Saccharimonadaceae bacteria is not fully understood ( Zhang, Meng, et al, 2022 ), but they are believed to contribute to carbon and nutrient cycling in their environment ( Zhang, Meng, et al, 2022 ).…”