The effects of blood transfusion on the prognosis of patients with gastric cancer

Abstract

The effect of perioperative blood transfusion on the survival rate of patients with gastric cancer was studied. One thousand patients with primary gastric cancer, who had curative surgery performed at the National Cancer Center Hospital in Japan from 1976 to 1981, were studied retrospectively. Overall comparison of transfused (n = 371) versus nontransfused (n = 629) patients by log rank analysis revealed a statistically significant adverse influence of blood transfusion on survival (p = 0.0001). Fifty-seven percent of transfused as compared to 80.8% of nontransfused patients survived for 5 years or more; however, after stratifying patients into stages and applying proportional regression analyses, blood transfusion did not appear to have any effect on prognosis: relative risk ratio, 1.16; p = 0.28. Similarly, comparison of patients transfused with more than 600 cc of blood and those transfused with 600 cc of blood or less revealed no statistical difference in survival time. It is postulated that the possible adverse influence of blood transfusion on the survival of patients with gastric cancer is linked to other prognostic features rather than to the immunologic sequelae of the transfusion itself.

Palliative gastrectomy and other factors affecting overall survival in stage IV gastric adenocarcinoma patients receiving chemotherapy: A retrospective analysis

“…A previous study by Kampschoer et al [23] showed no difference between 5-years survival rates in transfused and non-transfused patients grouped by stage and similar results were reported by others [24]. On the contrary, other reports, including an analysis of 1,710 patients with Stage III and IV gastric cancer by Hyung et al showed that survival in transfused patients was clearly poorer than in nontransfused patients [25], which is in accordance to our findings.…”

Melatonin treatment induces apoptosis through regulating the nuclear factor-κB and mitogen-activated protein kinase signaling pathways in human gastric cancer SGC7901 cells

“…The SGC7901 cells were seeded into 6-well plates at a concentration of 5x10 5 cells/well and cultured at 37˚C in a humidified atmosphere containing 5% CO 2 . On the following day, the cells were treated with 2 mM melatonin once and subsequently incubated at 37˚C for 8 days.…”

“…Due to the detection of the extent of early apoptosis and necrosis, SGC7901 cells were stained with fluorescein isothiocyanate (FITC)-conjugated Annexin V and propidium iodide (PI; Annexin V-FITC/PI apoptosis kit; Multi Sciences Biotech Co., Ltd., Hangzhou, China). In total, 4x10 5 cells were plated into 6-well plates and treated with 0, 0.5, 1 and 2 mM melatonin. Following a 24-h incubation, the cells were harvested by trypsinization and washed with PBS.…”

“…Gastric adenocarcinoma is the predominant type of gastric cancer and has limited treatment options (3). The typical treatments for gastric cancer, surgery and chemotherapy, only partially improve the overall survival of patients with this disease (4,5). Therefore, more effective drugs or comprehensive therapies are required (6).…”

Perioperative Blood Transfusions and Prognosis in Patients with Curatively Resected Locally Advanced Gastric Cancer

“…The adverse effect of perioperative blood transfusions has been studied in patients with breast cancer [3,4], lung cancer [5,6], soft tissue sarcoma [7], renal cell carcinoma [8], head and neck cancer [9], and most frequently in colo rectal cancer [10][11][12][13][14], Contradictory results have been reported on the effects of perioperative blood transfusions on the prognosis of patients with gastric cancer treated surgically [15][16][17], Therefore, we have undertaken an analysis to investi gate the relationship between perioperative blood transfu-sions and survival of patients with curatively resected locally advanced gastric cancer, which is the most com mon malignancy in Korea [18].…”