The effects of blueberry and cranberry supplementation on blood pressure in patients with cardiovascular diseases: A systematic review and <scp>meta‐analysis</scp> of randomized clinical trials

Delpino, Felipe Mendes; dos Santos, Francine Silva; Flores, Thaynã Ramos; Cerqueira, Henrique S.; Santos, Heitor O.

doi:10.1002/ptr.8069

Cited by 1 publication

(1 citation statement)

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“…Furthermore, supplementation with these fruits showed no significant effect on blood pressure in another study examining the impact of blueberries or cranberries on blood pressure ( Delpino et al, 2023 ), which is partially consistent with our research findings. We also found a non-significant result in systolic blood pressure, but the diastolic blood pressure was significantly decreased.…”

Section: Discussionsupporting

confidence: 91%

Effect of blueberry intervention on endothelial function: a systematic review and meta-analysis

Deng,

Lei,

Zhou

et al. 2024

Front. Physiol.

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Introduction: Endothelial dysfunction indicates blood vessel injury and is a risk factor for cardiovascular diseases. Blueberry has been approved for its benefits on human health, especially on cardiovascular function. However, its effect on endothelial function remains unclear. We conducted a systematic review and meta-analysis to explore the impact of blueberries on endothelial function in adults.Methods: We searched PubMed, Web of Science, Embase, and the Cochrane Library, 16 studies were included in the systematic review, and 11 were used for the meta-analysis. Data associated with endothelial function were extracted and pooled as mean differences (MD) with 95% confidence intervals (CI).Results: Blueberry consumption significantly improved flow-mediated dilation (FMD) by 1.50% (95% CI: 0.81, 2.20; I2 = 87%) and reactive hyperemia index (RHI) by 0.26 (95% CI: 0.09, 0.42; I2 = 72%). A significant decrease in diastolic blood pressure (DBP) was also observed (MD: −2.20 mm Hg; 95% CI: −4.13, −0.27; I2 = 11%). Subgroup analysis indicated a significant decrease in blood pressure (Systolic blood pressure [SBP]: −3.92 mmHg; 95% CI: −6.88, −0.97; I2 = 20% and DBP: −2.20 mmHg; 95% CI: −4.13, −0.27; I2 = 11%) in the smoking population. However, SBP levels (MD: −1.43 mm Hg; 95% CI: −3.11, 0.26; I2 = 20%) and lipid status (high-density lipoprotein cholesterol [HDL-C]: 0.06; 95% CI: −0.04, 0.16; I2 = 77%; low-density lipoprotein cholesterol [LDL-C]: 0.05; 95% CI: −0.14, 0.24; I2 = 0%) did not significantly improve.Conclusion: Blueberry intervention improved endothelial function and DBP. Subgroup analysis revealed a notable improvement in blood pressure among the smoking population. However, no significant effects were observed on SBP, HDL-C, and LDL-C levels. Future research should delve into the mechanisms of endothelial improvement and verify blood pressure reduction in specific subpopulations through large-scale trials.Clinical Trial Registration:https://www.crd.york.ac.uk/PROSPERO/, Identifier CRD42023491277.

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Section: Discussionsupporting

confidence: 91%