The effects of boron‐supplemented diets on adipogenesis‐related gene expressions, anti‐inflammatory, and antioxidative response in high‐fat fed rats

Abstract

The fatty liver syndrome caused by nutritional factors is a common cause of hepatic dysfunction globally. This research was designed to study the shielding effect of boron in rats fed a diet having high fat. Overall, 40 Wistar albino male rats were placed into one control and four treatment groups, that is, each having eight rats. Group I was provided with a standard rat diet while group II was only provided a high‐fat diet for 60 days. Groups III, IV, and V were provided with 5, 10, and 20 mg/kg/day boron, respectively, by gastric gavage besides a high‐fat diet for 60 days. Malondialdehyde was increased significantly in rats' blood and tissue because of high‐fat diets. Glutathione was decreased significantly in blood and tissues because of a high‐fat diet. Moreover, the activities of superoxide dismutase (SOD) and catalase (CAT) were decreased in the blood and tissues of the high‐fat‐fed rats. The genes expression for C‐reactive protein, interleukin‐1β, leptin, and tumor necrosis factor‐α were increased while gene expression for peroxisome proliferator‐activated receptors was decreased in the liver of rats fed with a high‐fat diet. Contrariwise, boron supplementation improves antioxidative response in terms of increased SOD and CAT activities, gene expression regulation, and improved anti‐inflammatory activities. In a nutshell, boron has dose‐dependent shielding antioxidative and tissue regenerative effects in rats.

The effect of different boron compounds on nutrient digestibility, intestinal nutrient transporters, and liver lipid metabolism

“…In the present study, SPP and BA supplementation increased PPARγ and decreased SREBP-1c, LxR-α, and FAS expression in the liver of rats. These data are consistent with earlier reports showing the effects of boron on lipid metabolism-related genes [ 21 , 39 ]. For example, Kucukkurt et al showed that 10 mg/kg B (as BA) increased PPARγ expression in the liver in HFD-fed rats [ 39 ].…”

“…These data are consistent with earlier reports showing the effects of boron on lipid metabolism-related genes [ 21 , 39 ]. For example, Kucukkurt et al showed that 10 mg/kg B (as BA) increased PPARγ expression in the liver in HFD-fed rats [ 39 ]. On the other hand, supplemental BA (30 mg/L B) in drinking water decreased the PPARγ in the liver [ 40 ].…”

“…Although there are no data regarding the effect of B compounds on LxR-α, it is well known that LxR-α can stimulate the SREBP-1c and FAS activity in the liver and increase lipid accumulation [ 41 ]. Additionally, while previous studies have shown that B may be effective in suppressing liver adipogenesis [ 21 , 39 , 40 ], these studies did not demonstrate the molecular mechanism of action of B on the LXR-α/SREBP-1c/FAS cascade in rat liver. Therefore, we show here for the first time that B can regulate lipogenesis in rat liver by inhibiting the LxR-α and possibly the LXR-α/SREBP-1c/FAS cascade.…”

Effects of boric acid on oxidant-antioxidant, proinflammatory cytokine levels, and biochemical parameters in aged rats

“…In a recent study, it was concluded that boron supplements affect lipid metabolism as a result of the relationship between total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels in rats fed a high-fat diet [36]. In our study, except for an important decrease in the H-BA group, the other study groups did not affect serum CHOL levels in aged rats.…”

Hekzagonal Boron Nitrür Nanopartikülleri Septik Sıçan Beyninde Nörodejenerasyonu Önler

“…In a study conducted by İnce and colleagues in rats with gentamicin-induced renal damage, it was observed that boron supplementation led to reduced expressions of TNF-α, NFκB, IL-1β, and IFN-γ mRNAs in the kidneys (20). Kucukkurt et al showed that boron decreased IL1-β and TNF-α gene expression levels in a dose-dependent manner in high-fat fed rats (21).…”