The effects of bupropion on sexual dysfunction in female patients with multiple sclerosis: A double-blind randomized clinical trial

Baghbanian, Seyed Mohammad; Khalili, Behnam; Bakhsi, Atieh; Azizi, Hanieh; Ghazaeian, Monireh

doi:10.1016/j.msard.2022.104399

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…As in our sample, the EDSS score, using different cut-off values, has been consistently related to SD in previous reports [ 56 , 58 – 60 ]. Specific sphincter symptoms, such as urinary incontinence or bowel dysfunction, could also negatively impact sexual function in individuals with MS [ 61 , 62 ], although we could not confirm this association. These symptoms can lead to discomfort or embarrassment during sexual activity, resulting in a decrease in sexual desire and satisfaction.…”

Section: Discussionmentioning

confidence: 78%

Reliability, validity and distribution of the Spanish female sexual function index in women with relapsing multiple sclerosis

Gil-Perotin,

Reddam,

González-Mingot

et al. 2023

BMC Women's Health

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Background The Female Sexual Function Index (FSFI) is a widely recognized tool for assessing sexual dysfunction (SD). However, its validation for Spanish women suffering from multiple sclerosis (MS) has not yet been conducted. Aim The study aimed to examine the psychometric properties of the 19-item Spanish version of the FSFI (svFSFI) in women with relapsing MS. Method A total of 137 women with relapsing MS from three Spanish centers participated in the study and completed the svFSFI. The psychometric properties of the questionnaire were evaluated. The prevalence of SD in the study cohort was determined, and its association with clinical and sociodemographic variables was analyzed using bi- and multivariate regression analyses. Results The svFSFI demonstrated excellent test-retest reliability and substantial-to-excellent internal consistency in the context of relapsing MS. There was significant convergent validity in the intercorrelations of domains. Discriminant validity showed differences in SD between women with high and low neurological disability, as measured by the Expanded Disability Status Scale (EDSS) scores. An exploratory factor analysis indicated a five-factor structure for the svFSFI. The prevalence of SD in the MS cohort was found to be 42.6%, with the ‘desire’ and ‘arousal’ domains being the most affected. Factors such as EDSS score, fatigue, depression, and having a stable partner were found to influence the total svFSFI score. Conclusion The study validates the svFSFI as a reliable and valid instrument for evaluating sexual dysfunction in Spanish women with MS.

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Section: Discussionmentioning

confidence: 78%

Reliability, validity and distribution of the Spanish female sexual function index in women with relapsing multiple sclerosis

Gil-Perotin,

Reddam,

González-Mingot

et al. 2023

BMC Women's Health

View full text Add to dashboard Cite

show abstract

“…Subsequently, psychoeducational interventions and medical approaches of anxiety and depressive symptoms have shown a positive impact on SD [70,71]. Age may also be a predictive factor for SD among women with MS, with older individuals potentially experiencing more di culties [65,69,[72][73][74].…”

Section: Discussionmentioning

confidence: 99%

Reliability, Validity and Distribution of the Spanish Female Sexual Function Index in Women with Multiple Sclerosis

Gil-Perotin,

Reddam,

González-Mingot

et al. 2023

Preprint

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The Spanish Female Sexual Function Index (FSFI) is a widely used scale to assess sexual dysfunction (SD), but its validation in Spanish women with multiple sclerosis (MS) has not been done. This cross-sectional multicenter study aimed to investigate the psychometric properties of the 19-item Spanish version of FSFI (svFSFI) in 137 women with MS and evaluate the prevalence of SD and its association with clinical and sociodemographic variables. Results showed excellent test-retest reliability and substantial-to-excellent internal consistency for the svFSFI. Convergent validity was significant in domain intercorrelations. Discriminant validity revealed differences in SD between women with high and low neurological disability, measured with Expanded Disability Status Scale (EDSS) scores. Exploratory factor analysis suggested a five-factor structure for the svFSFI. The prevalence of SD in the MS cohort was 42.6%, with 'desire' and 'arousal' being the most affected spheres. Only EDSS, fatigue, depression, and having a stable partner influenced the total svFSFI. The study confirmed the svFSFI as suitable for evaluating SD in Spanish women with MS. MS predominantly affects young women, making SD a frequent occurrence in this population. The study's strengths include a relatively large multicenter cohort and being the first validation of the svFSFI in women with MS. However, disbalanced patient numbers in EDSS categories and lack of responsiveness evaluation to intervention are limitations. Overall, the svFSFI is a reliable and valid questionnaire to assess sexual spheres in women with MS, revealing the prevalence of SD in this population.

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Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review

Fernández,

Sörensen,

Comi

et al. 2024

Front. Immunol.

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Multiple Sclerosis (MS) management in individuals aged 55 and above presents unique challenges due to the complex interaction between aging, comorbidities, immunosenescence, and MS pathophysiology. This comprehensive review explores the evolving landscape of MS in older adults, including the increased incidence and prevalence of MS in this age group, the shift in disease phenotypes from relapsing-remitting to progressive forms, and the presence of multimorbidity and polypharmacy. We aim to provide an updated review of the available evidence of disease-modifying treatments (DMTs) in older patients, including the efficacy and safety of existing therapies, emerging treatments such as Bruton tyrosine kinase (BTKs) inhibitors and those targeting remyelination and neuroprotection, and the critical decisions surrounding the initiation, de-escalation, and discontinuation of DMTs. Non-pharmacologic approaches, including physical therapy, neuromodulation therapies, cognitive rehabilitation, and psychotherapy, are also examined for their role in holistic care. The importance of MS Care Units and advance care planning are explored as a cornerstone in providing patient-centric care, ensuring alignment with patient preferences in the disease trajectory. Finally, the review emphasizes the need for personalized management and continuous monitoring of MS patients, alongside advocating for inclusive study designs in clinical research to improve the management of this growing patient demographic.

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The effects of bupropion on sexual dysfunction in female patients with multiple sclerosis: A double-blind randomized clinical trial

Cited by 3 publications

References 20 publications

Reliability, validity and distribution of the Spanish female sexual function index in women with relapsing multiple sclerosis

Reliability, validity and distribution of the Spanish female sexual function index in women with relapsing multiple sclerosis

Reliability, Validity and Distribution of the Spanish Female Sexual Function Index in Women with Multiple Sclerosis

Managing multiple sclerosis in individuals aged 55 and above: a comprehensive review

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