The effects of cadmium on VEGF‐mediated angiogenesis in HUVECs

Kim, Jisun; Lim, Wonbong; Ko, Youngjong; Kwon, HyukIl; Kim, Sang Woo; Kim, Ok-Su; Park, Gyeong-Ju; Choi, Hongran

doi:10.1002/jat.1677

Cited by 43 publications

(56 citation statements)

References 43 publications

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“…Significantly enriched GO terms included positive regulation of smooth muscle cell proliferation and cadmium ion binding. Interestingly, studies of human vascular endothelial cells suggest cadmium may alter angiogenesis and induce apoptosis through VEGF signaling [53].…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Investigation of Copy Number Variation in Patients with Sporadic Brain Arteriovenous Malformation

et al. 2013

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BackgroundBrain arteriovenous malformations (BAVM) are clusters of abnormal blood vessels, with shunting of blood from the arterial to venous circulation and a high risk of rupture and intracranial hemorrhage. Most BAVMs are sporadic, but also occur in patients with Hereditary Hemorrhagic Telangiectasia, a Mendelian disorder caused by mutations in genes in the transforming growth factor beta (TGFβ) signaling pathway.MethodsTo investigate whether copy number variations (CNVs) contribute to risk of sporadic BAVM, we performed a genome-wide association study in 371 sporadic BAVM cases and 563 healthy controls, all Caucasian. Cases and controls were genotyped using the Affymetrix 6.0 array. CNVs were called using the PennCNV and Birdsuite algorithms and analyzed via segment-based and gene-based approaches. Common and rare CNVs were evaluated for association with BAVM.ResultsA CNV region on 1p36.13, containing the neuroblastoma breakpoint family, member 1 gene (NBPF1), was significantly enriched with duplications in BAVM cases compared to controls (P = 2.2×10−9); NBPF1 was also significantly associated with BAVM in gene-based analysis using both PennCNV and Birdsuite. We experimentally validated the 1p36.13 duplication; however, the association did not replicate in an independent cohort of 184 sporadic BAVM cases and 182 controls (OR = 0.81, P = 0.8). Rare CNV analysis did not identify genes significantly associated with BAVM.ConclusionWe did not identify common CNVs associated with sporadic BAVM that replicated in an independent cohort. Replication in larger cohorts is required to elucidate the possible role of common or rare CNVs in BAVM pathogenesis.

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Section: Discussionmentioning

confidence: 99%

A Genome-Wide Investigation of Copy Number Variation in Patients with Sporadic Brain Arteriovenous Malformation

et al. 2013

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“…Vascular endothelial growth factor plays a major role in cell growth and angiogenesis under pathologic conditions (Kim et al, 2012). Vascular endothelial growth factor secretion is related to anti-apoptosis protein expression and attenuates apoptosis in endothelial cells (Kim et al, 2012). Under proper conditions, the endothelial cells will burrow into the matrix, align themselves, and differentiate into small capillary structures over an 18 h period .…”

Section: Blood Vessels Regeneration and CDmentioning

confidence: 99%

“…The effects of Cd involve the inflammation, hypertrophy, apoptosis, and angiogenesis resulted in vascular remodeling systems (Kim et al, 2012). The conditions under which capillaries and venules within the testes of most scrotumbearing mammals become sensitive and/or resistant to Cd are not yet known.…”

Section: Blood Vessels Regeneration and CDmentioning

confidence: 99%

“…These steps include basement membrane degradation, endothelial cell migration away from the vessel in response to a chemoattractant gradient, endothelial cell proliferation, and morphogenesis into tube-like structures (Hayden and Tyagi, 2004). Vascular endothelial growth factor plays a major role in cell growth and angiogenesis under pathologic conditions (Kim et al, 2012). Vascular endothelial growth factor secretion is related to anti-apoptosis protein expression and attenuates apoptosis in endothelial cells (Kim et al, 2012).…”

Section: Blood Vessels Regeneration and CDmentioning

confidence: 99%

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Toxic effects of cadmium on testis of birds and mammals: A review

Marettová

Maretta

Legáth

2015

Animal Reproduction Science

132

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“…The effect was termed ''paradoxical'' because cadmium, a known carcinogen, exerted an apparent anti-cancer effect by inhibiting cancer cell-stimulated angiogenesis. The effects of cadmium on angiogenesis, however, are complex and a dual effect has been recently described: it appears that at low dose it stimulates angiogenesis, whereas at higher doses it inhibits new blood vessel formation [29]. The role Fig.…”

Section: Cadmium and Angiogenesis In Me/cfsmentioning

confidence: 99%

Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

et al. 2012

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a b s t r a c tAccording to the World Health Organization, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/ CFS) is a neurological disease characterized by widespread inflammation and multi-systemic neuropathology. Aetiology and pathogenesis are unknown, and several agents have been proposed as causative agents or as factors perpetuating the syndrome. Exposure to heavy metals, with particular reference to mercury and gold in dental amalgams, has been considered among the triggers of ME/CFS. Here we hypothesize that cadmium, a widespread occupational and environmental heavy metal pollutant, might be associated with some of the neurological findings described in ME/CFS. In fact, ME/CFS patients show a decrease of the volume of the gray matter in turn associated with objective reduction of physical activity. Cadmium induces neuronal death in cortical neurons through a combined mechanism of apoptosis and necrosis and it could then be hypothesized that cadmium-induced neuronal cell death is responsible for some of the effects of cadmium on the central nervous system, i.e. a decrease in attention level and memory in exposed humans as well as to a diminished ability for training and learning in rats, that are symptoms typical of ME/CFS. This hypothesis can be tested by measuring cadmium exposure in a cohort of ME/CFS patients compared with matched healthy controls, and by measuring gray matter volume in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. In addition, we hypothesize that cadmium exposure could be associated with reduced cerebral blood flow in ME/CFS patients because of the disruptive effects of cadmium on angiogenesis. In fact, cadmium inhibits angiogenesis and low global cerebral flow is associated with abnormal brain neuroimaging results and brain dysfunction in the form of reduced cognitive testing scores in ME/CFS patients. This hypothesis can be tested by measuring cerebral cortex blood flow in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. If our hypothesis is demonstrated correct, the consequences could affect prevention, early diagnosis, and treatment of ME/CFS. Implications in early diagnosis could entail the evaluation of symptoms typical of ME/CFS in cadmium-exposed subjects as well as the search for signs of exposure to cadmium in subjects diagnosed with ME/CFS. Nutritional supplementation of magnesium and zinc could then be considered, since these elements have been proposed in the prophylaxis and therapy of cadmium exposure, and magnesium was demonstrated effective on ME/CFS patients' symptom profiles.

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The effects of cadmium on VEGF‐mediated angiogenesis in HUVECs

Cited by 43 publications

References 43 publications

A Genome-Wide Investigation of Copy Number Variation in Patients with Sporadic Brain Arteriovenous Malformation

A Genome-Wide Investigation of Copy Number Variation in Patients with Sporadic Brain Arteriovenous Malformation

Toxic effects of cadmium on testis of birds and mammals: A review

Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

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