The Effects of Caffeine on l-Arginine Metabolism in the Brain of Rats

Ofluoglu, Ebru; Paşaoğlu, Hatîce; Paşaoğlu, Aydın

doi:10.1007/s11064-008-9790-x

Cited by 22 publications

(15 citation statements)

References 34 publications

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“…Also caffeine's ability to mop up peroxide radicals [63] may be responsible for the slight increase in SOD activity seen at low doses of caffeine in this study. However, studies have also shown that the effects of caffeine on antioxidant status are dose related; with reports of increased oxidative stress with high doses of caffeine [67], [68]. The significant increase in SOD activity and decrease in GPX activity seen in this study (with increasing doses of caffeine) is suggestive of oxidative stress.…”

Section: Discussionsupporting

confidence: 65%

Caffeine and sleep-deprivation mediated changes in open-field behaviours, stress response and antioxidant status in mice

Onaolapo

Akanmu

et al. 2016

Sleep Science

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ObjectivesEffects of daily caffeine consumption on open-field behaviours, serum corticosterone and brain antioxidant levels were investigated after six hours of total sleep-deprivation in prepubertal mice. We tested the hypothesis that daily caffeine consumption may significantly alter behaviour, stress and antioxidative response of prepubertal mice to an acute episode of total sleep-deprivation.MethodsPrepubertal Swiss mice of both sexes were assigned to two main groups of 120 each (subdivided into 6 groups of 10 each, based on sex), and administered vehicle or graded oral doses of caffeine (10, 20, 40, 80 and 120 mg/kg/day) for 14 days. On day 14, a main group was subjected to 6 h of total sleep-deprivation by ‘gentle-handling’. Open-field behaviours were then assessed in both groups, after which animals were euthanized, and levels of corticosterone, superoxide dismutase and glutathione peroxidase assayed.ResultsHorizontal locomotion, rearing and grooming increased significantly, compared to control, with sleep-deprived (SD) mice showing stronger caffeine-driven responses at higher doses; and SD female mice showing sustained response to caffeine, compared to respective males. Plasma corticosterone increased with increasing doses of caffeine in both non sleep-deprived (NSD) and SD mice; although SD mice had higher corticosterone levels. Sleep-deprivation and/or higher doses of caffeine were associated with derangements in brain antioxidant levels.ConclusionRepeated caffeine consumption and/or acute sleep-deprivation led to significant changes in pattern of open-field behaviour and stress/antioxidant response in mice. Responses seen in the study are probably due to modulatory effects of caffeine on the total body response to stressful stimuli.

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Section: Discussionsupporting

confidence: 65%

Caffeine and sleep-deprivation mediated changes in open-field behaviours, stress response and antioxidant status in mice

Onaolapo

Akanmu

et al. 2016

Sleep Science

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“…These results suggest that acknowledged mechanisms of the action of caffeine, like increased NO production (Ofluoglu et al 2009;Corsetti et al 2008) or its antioxidant activity (Scharf et al 2001)) are not involved in the reversal of age-related insulin resistance induced by the drug.…”

Section: Discussionmentioning

confidence: 88%

Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity

Ribeiro¹,

Sacramento²,

Conde³

2012

AGE

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The role of caffeine consumption on insulin action is still under debate. The hypothesis that chronic caffeine intake reverses aging-induced insulin resistance in the rat was tested in this work. The mechanism by which caffeine restores insulin sensitivity was also investigated. Six groups of rats were used: 3 months old (3 M), 3 months old caffeine-treated (3MCaf), 12 months old (12 M), 12 months old caffeine-treated (12MCaf), 24 months old (24 M), and 24 months old caffeinetreated (24MCaf). Caffeine was administered in drinking water (1 g/l) during 15 days. Insulin sensitivity was assessed by means of the insulin tolerance test. Blood pressure, body weight, visceral and total fat, fasting glycemia and insulinemia, plasma nonesterified fatty acids (NEFA), total antioxidant capacity (TAC), cortisol, nitric oxide, and catecholamines were monitored. Skeletal muscle Glut4 and 5′-AMP activated protein kinase (AMPK) protein expression and activity were also assessed. Aged rats exhibited diminished insulin sensitivity accompanied by hyperinsulinemia and normoglycemia, increased visceral and total fat, decreased TAC and plasma catecholamines, and also decreased skeletal muscle Glut4 and AMPK protein expression. Chronic caffeine intake restored insulin sensitivity and regularized circulating insulin and NEFA in both aging models. Caffeine neither modified skeletal muscle AMPK expression nor activity in aged rats; however, it decreased visceral and total fat in 12 M rats and it restored skeletal muscle Glut4 expression to control values in 24 M rats. We concluded that chronic caffeine intake reverses aging-induced insulin resistance in rats by decreasing NEFA production and also by increasing Glut4 expression in skeletal muscle.

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“…between 10:00 a.m. and 10:30 a.m. This caffeine dose is known as high but nontoxic (Deurveilher et al 2006;Lage et al 2006;Pettenuzzo et al 2008;Ofluoglu et al 2009;Westerterp-Plantenga 2010). After being injected, the rats were returned to their home cage and given food and water ad libitum.…”

Section: Caffeine Administrationmentioning

confidence: 99%

“…During 7 days, caffeine was given in drinking water (0.5 g/L and 1.0 g/L). The control group was given distilled water (Méndez et al 2008;Ofluoglu et al 2009), and both body weight and food intake were monitored every day. Caffeine consumption, at both doses, significantly reduced body weight over the course of the 7 days ( Figure 1A).…”

Section: Effects Of Caffeine On Body Weight and Food Intakementioning

confidence: 99%

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Expression of pro-opiomelanocortin and agouti-related protein in the hypothalamus of caffeine-administered rats

Jeong

Lee

et al. 2011

Animal Cells and Systems

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In the present study, we examined the effects of caffeine on food intake and body weight, and pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) expression in the hypothalamus. Rats were administered intraperitoneally with 100 mg/kg caffeine (a high, non-toxic dose) or saline during the light phase. Intraperitoneal administration of caffeine induced a significant reduction in food intake and body weight 12 hr after treatment. In addition, POMC expression was significantly increased and AgRP expression was decreased in the arcuate nucleus (Arc) after caffeine treatment. These results demonstrate that administration of caffeine up-regulates POMC expression and down-regulates AgRP expression in the Arc, suggesting that the activation of the hypothalamic POMC neurons and inhibition of the AgRP neurons might play a role in the regulation of food intake and body weight by caffeine.

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The Effects of Caffeine on l-Arginine Metabolism in the Brain of Rats

Cited by 22 publications

References 34 publications

Caffeine and sleep-deprivation mediated changes in open-field behaviours, stress response and antioxidant status in mice

Caffeine and sleep-deprivation mediated changes in open-field behaviours, stress response and antioxidant status in mice

Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity

Expression of pro-opiomelanocortin and agouti-related protein in the hypothalamus of caffeine-administered rats

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