The effect of feeding adult Swiss albino mice of both sexes a diet supplemented with 0, 125, 250 and 500 parts/106 of fluoride for four and eight week periods on haemoglobin concentration (Hb), packed cell volume (PCV) and mean corpuscular haemoglobin concentration (MCHC) was investigated. Values of the three parameters were significantly lowered at both periods in the treated groups as compared with the controls. The extent of reduction in these values was, in general, dependent on the dose of supplemented dietary fluoride. Clinical symptoms were not observed before the end of the sixth week. However, appearance of the symptoms did not change the trend of variations in Hb, PCV and MCHC values. The reduced values could be the result of lowered haemoglobin synthesis and erythropoiesis. It was suggested that these haematological indices could serve to detect preclinical effects of high fluoride intake with an added dose of as low as 125 parts/106, or even less, for a period of four weeks or probably earlier.There have been many studies of the adverse effects of high fluoride intake on bones and teeth of man and animals [Velu, 1932;MacIntire, Winterberg, Clements and Dunham, 1947; Neeley and Harbaugh, 1954;Merriman, Moorman and Hobbs, 1956;Brown, Christofferson, Massler and Weiss, 1960;Johnson, 1965;Shupe, 1969;Bhussry, 1970;McClure, 1970;Jones, 1972;Rosenquist and Lemperg, 1974;Yamamoto, Wergedal and Baylink, 1974;Gileva, Plotko and Gatiyatullina, 1975;Lough, Noonan, Gagnon and Kayne, 1975]. Other tissues, however, as possible affected sites have received less attention. Research reports describing the effects of high levels of fluoride on the blood picture and haematopoietic system are not so frequently encountered.Hoogstratten, Leone, Shupe, Greenwood and Liberman [1965] reported an increase in blood and bone marrow eosinophils and a decrease in serum folic acid activity of cattle received a fluoride-supplemented ration for a period of seven and a half years. The daily ingested level of fluoride was 93 parts/106.Decreased blood levels of copper and calcium, as well as lowered values of packed cell volume (PCV), were observed in sheep grazing, for not less than two years, on pasture contaminated with rock phosphate dust containing 2-1-3-3 % of fluoride emitted from a fertilizer factory [Zumpt, 1975]. The concentration of fluoride in the grazed forage, on a dry matter basis, was 232 parts/106. The effect of a high level of fluoride on some haematological aspects of the rat was investigated by Kahl, Wojcik and Ewy [1973]. Sodium fluoride at a concentration of 150 parts/106 in drinking water lowered, after 75 days, the erythrocyte count and haemoglobin concentration (Hb) down to 20-2 % and 4.5 % of those of the controls, respectively. Decreased incorporation of 59Fe into red blood cells and spleen was also observed along with increased 59Fe incorporation into liver and bone marrow.