The effects of carbamazepine on macroinvertebrate species: Comparing bivalves and polychaetes biochemical responses

Freitas, Rosa; Almeida, Ângela; Pires, Adília; Velez, Cátia; Calisto, Vânia; Schneider, R.; Esteves, Valdemar I.; Wrona, Frederick J.; Figueira, Etelvina; Soares, Amadeu M.V.M.

doi:10.1016/j.watres.2015.08.003

Cited by 83 publications

(24 citation statements)

References 99 publications

(144 reference statements)

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“…The tissue‐specific bioconcentration factors (BCFs) were calculated according to the measured water concentration and the concentrations in each tissue, and these are summarized in Table . In brain BCFs were higher when compared to the other tissues, especially at the lowest exposure concentration, mirroring what has been observed in previous studies . The tissue to plasma ratios were also calculated and are summarized in Table and Figure A.…”

Section: Resultssupporting

confidence: 81%

Anti‐anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects

Huerta

Margiotta-Casaluci

Rodríguez-Mozaz

et al. 2016

Enviro Toxic and Chemistry

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Psychoactive drugs are frequently detected in the aquatic environment. The evolutionary conservation of the molecular targets of these drugs in fish suggests that they may elicit mode of action-mediated effects in fish as they do in humans, and the key open question is at what exposure concentrations these effects might occur. In the present study, the authors investigated the uptake and tissue distribution of the benzodiazepine oxazepam in the fathead minnow (Pimephales promelas) after 28 d of waterborne exposure to 0.8 mg L À1 , 4.7 mg L À1 , and 30.6 mg L À1 . Successively, they explored the relationship between the internal concentrations of oxazepam and the effects on fish exploratory behavior quantified by performing 2 types of behavioral tests, the novel tank diving test and the shelterseeking test. The highest internal concentrations of oxazepam were found in brain, followed by plasma and liver, whereas muscle presented the lowest values. Average concentrations measured in the plasma of fish from the 3 exposure groups were, respectively, 8.7 AE 5.7 mg L À1 , 30.3 AE 16.1 mg L À1 , and 98.8 AE 72.9 mg L À1 . Significant correlations between plasma and tissue concentrations of oxazepam were found in all 3 groups. Exposure of fish to 30.6 mg L À1 in water produced plasma concentrations within or just below the human therapeutic plasma concentration (H T PC) range in many individuals. Statistically significant behavioral effects in the novel tank diving test were observed in fish exposed to 4.7 mg L À1 . In this group, plasma concentrations of oxazepam were approximately one-third of the lowest H T PC value. No significant effects were observed in fish exposed to the lowest and highest concentrations. The significance of these results is discussed in the context of the species-specific behavior of fathead minnow and existing knowledge of oxazepam pharmacology.

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Section: Resultssupporting

confidence: 81%

Anti‐anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects

Huerta

Margiotta-Casaluci

Rodríguez-Mozaz

et al. 2016

Enviro Toxic and Chemistry

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“…In Figure 1A we report the IR spectrum of synthetized GO which displays several spectral features: a broad band centered at 3450 cm -1 (assigned to the stretching of OH groups); a medium intensity band near 1720 cm -1 (assigned to the stretching of carbonyl bonds); a strong structured band peaking at 1580 cm -1 (assigned to the stretching of polarized C=C bonds) with a shoulder at 1620 cm -1 (assigned to the carboxylic CO stretching); a broad and structured feature ranging from 1400 cm -1 to 1000 cm -1 whose most prominent peak at 1240 cm -1 is assigned to the antisymmetric stretching vibrations of the C-O-C moieties. All these bands originate from oxygen bearing functional groups attached to the C=C sp 2 network of GO and provide a characteristic spectral pattern usually observed in this class of materials (Marcano et al, 2010;Shen et al, 2009;Acik et al, 2010;Agorku et al, 2015). Particularly our results are in agreement with study conducted by Jastrzębska et al (2016) who showed all these types of vibrations occurred in pure GO.…”

Section: Characterization Gomentioning

confidence: 84%

Physiological and biochemical impacts of graphene oxide in polychaetes: The case of Diopatra neapolitana

Marchi

Neto

Pretti

et al. 2017

Comparative Biochemistry and Physiology Part C: Toxicology &

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Graphene oxide (GO) is an important carbon nanomaterial (NM) that has been used, but limited literature is available regarding the impacts induced in aquatic organisms by this pollutant and, in particular in invertebrate species. The polychaete Diopatra neapolitana has frequently been used to evaluate the effects of environmental disturbances in estuarine systems due to its ecological and socio-economic importance but to our knowledge no information is available on D. neapolitana physiological and biochemical alterations due to GO exposure. Thus, the present study aimed to assess the toxic effects of different concentrations of GO (0.01; 0.10 and 1.00mg/L) in D. neapolitana physiological (regenerative capacity) and biochemical (energy reserves, metabolic activity and oxidative stress related biomarkers) performance, after 28days of exposure. The results obtained revealed that the exposure to GO induced negative effects on the regenerative capacity of D. neapolitana, with organisms exposed to higher concentrations regenerating less segments and taking longer periods to completely regenerate. GO also seemed to alter energy-related responses, especially glycogen content, with higher values in polychaetes exposed to GO which may result from a decreased metabolism (measured by electron transport system activity), when exposed to GO. Furthermore, under GO contamination D. neapolitana presented cellular damage, despite higher activities of antioxidant and biotransformation enzymes in individuals exposed to GO.

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“…The biochemical markers have been widely used in environmental monitoring studies to assess the impacts of single/mixture of pollutants (Yusa etal.,2015;Freitas et al, 2015;Velez et al, 2015). The toxicity of pesticides also appears to be related to their biotransformation into (Abdollahi et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Pesticides contaminated dust exposure, risk diagnosis and exposure markers in occupational and residential settings of Lahore, Pakistan

Halsall

Sweetman

Jones

et al. 2017

Environmental Toxicology and Pharmacology

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There are few studies documenting the dust loaded with pesticides as a potential non-dietary exposure source for occupational worker and populations living near agricultural farms and pesticides formulation plants. In present study we have evaluated the pesticide concentration in dust from potential sites and relevant health risk from dust ingestion. Furthermore, the effect of currently used pesticides was investigated on blood and urine parameters of subjects: farmer, factory worker, urban resident and rural resident and controlled subjects with presumably different levels of exposure. The urinary metabolites (TCPY and IMPY) were quantified as biomarkers of exposure to chlorpyrifos and diazinon in relation with biomarkers of effect including BuChE, LH, FSH, testosterone and oxidative stress. Results showed that chlorpyrifos and diazinon were present in higher concentration in dust and posed a high health risk to exposed subjects. The mean SOD value was high among the farmer (3048U/g Hb) followed by factory worker (1677.6U/g Hb). The urinary biomarkers - TCPY and IMPY- were found higher in exposed subjects as compared to control. Furthermore, testosterone was found in higher concentration in factory worker than control (12.63ng/ml vs 4.61ng/ml respectively). A decreased BuChE activity was noticed in occupational group and significant differences were observed in control verses exposed subjects. The PCA analysis evidenced the impact of pesticides on exposure biomarkers and male reproductive hormones. The study suggests that dust contaminated with pesticides engenders significant health risk particularly related to the nervous and endocrine system, not only for occupational workers exposed to direct ingestion but also for nearby residential community. Succinctly putting: Pesticides loaded dust in the city of Lahore, being a high priority concern for the government of Pakistan, demands to be addressed.

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The effects of carbamazepine on macroinvertebrate species: Comparing bivalves and polychaetes biochemical responses

Cited by 83 publications

References 99 publications

Anti‐anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects

Anti‐anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects

Physiological and biochemical impacts of graphene oxide in polychaetes: The case of Diopatra neapolitana

Pesticides contaminated dust exposure, risk diagnosis and exposure markers in occupational and residential settings of Lahore, Pakistan

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