The effects of cardiometabolic factors on the association between serum uric acid and risk of all-cause mortality in adults with congestive heart failure

Liu, Tao; Song, Jia; Zuo, Ronghua; Sun, Lifang; Zhu, Zhijian; Wang, Bing; Lu, Zhigang; Pan, Yesheng

doi:10.1080/00325481.2023.2210933

Cited by 1 publication

(1 citation statement)

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“…Notably, our findings revealed a U-shaped pattern of nonlinear relationships between serum urate levels and mortality risk, indicating that mortality risk consistently increased again as urate levels decreased below the inflection point. This result is consistent with previous studies using large samples of individuals in the general population (44, 45) and those assessing patients with cardiovascular diseases (46)(47)(48). Although the exact reasons for the heightened mortality risk associated with low levels of serum urate remain unclear, several potential explanations exist.…”

Section: Discussionsupporting

confidence: 92%

Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001–2018

Yin,

Zhou,

2024

Front. Cardiovasc. Med.

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ObjectiveThe prevalence of hyperuricemia and hypertension is steadily increasing, and these conditions often share common risk factors. This study aimed to investigate the association among hyperuricemia, hypertension, and all-cause mortality in a nationally representative U.S. population.MethodsData for 38,644 participants were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001–2018. Hyperuricemia was defined as a serum urate concentration >420 μmol/L in men and >360 μmol/L in women. Information regarding death outcomes was obtained through the National Death Index (NDI). Multivariate logistic regression, Cox proportional hazards models, and restricted cubic spline (RCS) analyses were used to evaluate the association between hyperuricemia and hypertension in all included participants, as well as long-term mortality in patients with hypertension.ResultsAmong all participants, 6,956 (18.0%) had hyperuricemia, while 31,688 (82.0%) had nonhyperuricemia. According to the adjusted models, hyperuricemia was more strongly associated with hypertension (OR 2.04) than was non-hyperuricemia. During the median follow-up period of 78 months, both hyperuricemia (HR 1.48, 1.95) and hypertension (HR 1.42, 1.69) independently associated with the increased risk of all-cause mortality and cardiovascular mortality, respectively, with the highest risk observed in those with both conditions (HR 1.87, 2.82). RCS analyses revealed nonlinear J-shaped (for hypertension) and U-shaped (for both all-cause and cardiovascular mortality) relationships with serum urate levels.ConclusionsHyperuricemia is associated with an elevated risk of developing hypertension compared to non-hyperuricemia. Among patients with hypertension, those with hyperuricemia are more likely to experience all-cause and cardiovascular mortality during long-term follow-up.

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Section: Discussionsupporting

confidence: 92%